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Effect of dietary fish oil (active EPA-30) on liver phospholipids in young and aged rats.

Abstract

We explored the uses of fish oil (active EPA-30) as a source of eicosapentaenate (EPA; 20:5 n-3), to young and old rats. We treated three subgroups of rats each comprising 20 young or old rats, respectively. The first group was kept on the basal ration (lab-pellet) as control diet, the second group was fed semi-purified diets contained 5% pig-fat (n-3 fatty acids deficient diet). The third group was fed a modified diet in which 50% of pig-fat was replaced by active EPA-30. Livers of young rats fed pig-fat had a drastic decrease in the amount of phosphatidylethanolamine (PE) and omega-3 polyunsaturated fatty acids (EPA, 20:5 n-3 and docosahexaenoic, DHA, 22:6 n-3) and compensatory increase of phosphatidylcholine, saturated fatty acids and n-6 polyunsaturated fatty acids in the liver phospholipids. In contrast, the liver of young rats fed active EPA-30 had large amounts of PE and concomitant enrichment in polyunsaturated fatty acids. The liver of old rats, fed on active EPA-30 supplemented diet had lower amounts of PE and there were no significant changes in the phospholipid fatty acid composition.

Authors+Show Affiliations

Department of Biochemistry, Attilla Joszef University, Szeged, Hungary.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10356759

Citation

Kotkat, H M., et al. "Effect of Dietary Fish Oil (active EPA-30) On Liver Phospholipids in Young and Aged Rats." Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, vol. 122, no. 3, 1999, pp. 283-9.
Kotkat HM, Rady AA, Nemcsok J. Effect of dietary fish oil (active EPA-30) on liver phospholipids in young and aged rats. Comp Biochem Physiol A Mol Integr Physiol. 1999;122(3):283-9.
Kotkat, H. M., Rady, A. A., & Nemcsok, J. (1999). Effect of dietary fish oil (active EPA-30) on liver phospholipids in young and aged rats. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 122(3), 283-9.
Kotkat HM, Rady AA, Nemcsok J. Effect of Dietary Fish Oil (active EPA-30) On Liver Phospholipids in Young and Aged Rats. Comp Biochem Physiol A Mol Integr Physiol. 1999;122(3):283-9. PubMed PMID: 10356759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary fish oil (active EPA-30) on liver phospholipids in young and aged rats. AU - Kotkat,H M, AU - Rady,A A, AU - Nemcsok,J, PY - 1999/6/5/pubmed PY - 1999/6/5/medline PY - 1999/6/5/entrez SP - 283 EP - 9 JF - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology JO - Comp Biochem Physiol A Mol Integr Physiol VL - 122 IS - 3 N2 - We explored the uses of fish oil (active EPA-30) as a source of eicosapentaenate (EPA; 20:5 n-3), to young and old rats. We treated three subgroups of rats each comprising 20 young or old rats, respectively. The first group was kept on the basal ration (lab-pellet) as control diet, the second group was fed semi-purified diets contained 5% pig-fat (n-3 fatty acids deficient diet). The third group was fed a modified diet in which 50% of pig-fat was replaced by active EPA-30. Livers of young rats fed pig-fat had a drastic decrease in the amount of phosphatidylethanolamine (PE) and omega-3 polyunsaturated fatty acids (EPA, 20:5 n-3 and docosahexaenoic, DHA, 22:6 n-3) and compensatory increase of phosphatidylcholine, saturated fatty acids and n-6 polyunsaturated fatty acids in the liver phospholipids. In contrast, the liver of young rats fed active EPA-30 had large amounts of PE and concomitant enrichment in polyunsaturated fatty acids. The liver of old rats, fed on active EPA-30 supplemented diet had lower amounts of PE and there were no significant changes in the phospholipid fatty acid composition. SN - 1095-6433 UR - https://www.unboundmedicine.com/medline/citation/10356759/Effect_of_dietary_fish_oil__active_EPA_30__on_liver_phospholipids_in_young_and_aged_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1095-6433(98)10168-X DB - PRIME DP - Unbound Medicine ER -