Tags

Type your tag names separated by a space and hit enter

Does a family history of cancer increase the risk for postmenopausal endometrial carcinoma? A prospective cohort study and a nested case-control family study of older women.

Abstract

BACKGROUND

As part of the hereditary nonpolyposis colon carcinoma (HNPCC) constellation of neoplasia caused by defects in mismatch repair genes, some endometrial carcinomas are known to have a genetic contribution to etiology. However, most endometrial carcinomas occur in postmenopausal women, presumably without the HNPCC defect. Consequently, the genetic contribution to these cases is unclear. The objective of this study was to determine whether family history of cancer is a risk factor for endometrial carcinoma in older women.

METHODS

The authors analyzed incident endometrial carcinoma data, as well as data on family history of various cancers in first-degree relatives, from a cohort of 24,848 postmenopausal Iowa women ages 55-69 years who were cancer free at baseline in 1986. Because a positive family history is dependent on many factors, including the age of the patient, the number of relatives, and the distribution of other risk factors in relatives, the authors also conducted a nested case-control study on family members of 95 patients with endometrial carcinoma diagnosed during 1988-1989 and 91 cancer free controls who were chosen randomly from subjects matched for age (+/-1 year).

RESULTS

During 10 years of follow-up of the cohort, 322 incident endometrial carcinoma cases occurred. Women who reported a positive family history of cancer overall or at any specific site (e.g., the endometrium, colon, or breast) were not at increased risk for endometrial carcinoma. Adjustment for potential confounders, such as age, obesity, parity, oral contraceptive use, and estrogen replacement therapy, did not alter these results. Analysis of the family members of the cases and controls produced little evidence to suggest that this lack of association between family history and endometrial carcinoma could be explained by unequal distribution of known risk factors among relatives. Case family members were slightly older than control family members, but no significant differences were found in body mass index (kg/m2), age at menarche, age at menopause, or number of pregnancies. Relation to a case or control was not associated with increased risk of endometrial, ovarian, breast, or colon carcinoma for family members. Controlling for a variety of potential confounders did not alter the results.

CONCLUSIONS

No evidence was found that genetics contribute to the risk of postmenopausal endometrial carcinoma for women with no personal cancer history.

Authors+Show Affiliations

,

Department of Health Sciences Research, Mayo Clinic, and Mayo Clinic Cancer Center, Rochester, Minnesota, USA.

, ,

Source

Cancer 85:11 1999 Jun 01 pg 2444-9

MeSH

Aged
Case-Control Studies
Colorectal Neoplasms, Hereditary Nonpolyposis
Endometrial Neoplasms
Family Health
Female
Humans
Medical History Taking
Middle Aged
Neoplasms
Postmenopause
Prospective Studies
Risk Factors

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10357416

Citation

Olson, J E., et al. "Does a Family History of Cancer Increase the Risk for Postmenopausal Endometrial Carcinoma? a Prospective Cohort Study and a Nested Case-control Family Study of Older Women." Cancer, vol. 85, no. 11, 1999, pp. 2444-9.
Olson JE, Sellers TA, Anderson KE, et al. Does a family history of cancer increase the risk for postmenopausal endometrial carcinoma? A prospective cohort study and a nested case-control family study of older women. Cancer. 1999;85(11):2444-9.
Olson, J. E., Sellers, T. A., Anderson, K. E., & Folsom, A. R. (1999). Does a family history of cancer increase the risk for postmenopausal endometrial carcinoma? A prospective cohort study and a nested case-control family study of older women. Cancer, 85(11), pp. 2444-9.
Olson JE, et al. Does a Family History of Cancer Increase the Risk for Postmenopausal Endometrial Carcinoma? a Prospective Cohort Study and a Nested Case-control Family Study of Older Women. Cancer. 1999 Jun 1;85(11):2444-9. PubMed PMID: 10357416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does a family history of cancer increase the risk for postmenopausal endometrial carcinoma? A prospective cohort study and a nested case-control family study of older women. AU - Olson,J E, AU - Sellers,T A, AU - Anderson,K E, AU - Folsom,A R, PY - 1999/6/5/pubmed PY - 2000/6/20/medline PY - 1999/6/5/entrez SP - 2444 EP - 9 JF - Cancer JO - Cancer VL - 85 IS - 11 N2 - BACKGROUND: As part of the hereditary nonpolyposis colon carcinoma (HNPCC) constellation of neoplasia caused by defects in mismatch repair genes, some endometrial carcinomas are known to have a genetic contribution to etiology. However, most endometrial carcinomas occur in postmenopausal women, presumably without the HNPCC defect. Consequently, the genetic contribution to these cases is unclear. The objective of this study was to determine whether family history of cancer is a risk factor for endometrial carcinoma in older women. METHODS: The authors analyzed incident endometrial carcinoma data, as well as data on family history of various cancers in first-degree relatives, from a cohort of 24,848 postmenopausal Iowa women ages 55-69 years who were cancer free at baseline in 1986. Because a positive family history is dependent on many factors, including the age of the patient, the number of relatives, and the distribution of other risk factors in relatives, the authors also conducted a nested case-control study on family members of 95 patients with endometrial carcinoma diagnosed during 1988-1989 and 91 cancer free controls who were chosen randomly from subjects matched for age (+/-1 year). RESULTS: During 10 years of follow-up of the cohort, 322 incident endometrial carcinoma cases occurred. Women who reported a positive family history of cancer overall or at any specific site (e.g., the endometrium, colon, or breast) were not at increased risk for endometrial carcinoma. Adjustment for potential confounders, such as age, obesity, parity, oral contraceptive use, and estrogen replacement therapy, did not alter these results. Analysis of the family members of the cases and controls produced little evidence to suggest that this lack of association between family history and endometrial carcinoma could be explained by unequal distribution of known risk factors among relatives. Case family members were slightly older than control family members, but no significant differences were found in body mass index (kg/m2), age at menarche, age at menopause, or number of pregnancies. Relation to a case or control was not associated with increased risk of endometrial, ovarian, breast, or colon carcinoma for family members. Controlling for a variety of potential confounders did not alter the results. CONCLUSIONS: No evidence was found that genetics contribute to the risk of postmenopausal endometrial carcinoma for women with no personal cancer history. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/10357416/Does_a_family_history_of_cancer_increase_the_risk_for_postmenopausal_endometrial_carcinoma_A_prospective_cohort_study_and_a_nested_case_control_family_study_of_older_women_ L2 - http://www.diseaseinfosearch.org/result/8312 DB - PRIME DP - Unbound Medicine ER -