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Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men.
Am J Clin Nutr. 1999 Jun; 69(6):1144-50.AJ

Abstract

BACKGROUND

Dietary plant sterols (phytosterols) have been shown to lower plasma lipid concentrations in animals and humans. However, the effect of phytosterol intake from tall oil on cholesterol and phytosterol metabolism has not been assessed in subjects fed precisely controlled diets.

OBJECTIVE

Our objective was to examine the effects of sitostanol-containing phytosterols on plasma lipid and phytosterol concentrations and de novo cholesterol synthesis rate in the context of a controlled diet.

DESIGN

Thirty-two hypercholesterolemic men were fed either a diet of prepared foods alone or a diet containing 1.7 g phytosterols/d for 30 d in a parallel study design.

RESULTS

No overall effects of diet on total cholesterol concentrations were observed, although concentrations were lower with the phytosterol-enriched than with the control diet on day 30 (P < 0.05). LDL-cholesterol concentrations on day 30 had decreased by 8.9% (P < 0.01) and 24.4% (P < 0.001) with the control and phytosterol-enriched diets, respectively. HDL-cholesterol and triacylglycerol concentrations did not change significantly. Moreover, changes in circulating campesterol and beta-sitosterol concentrations were not significantly different between phytosterol-fed and control subjects. In addition, there were no significant differences in fractional (0.091 +/- 0.028 and 0.091 +/- 0.026 pool/d, respectively) or absolute (0.61 +/- 0.24 and 0.65 +/- 0.23 g/d, respectively) synthesis rates of cholesterol observed between control and phytosterol-fed subjects.

CONCLUSION

Addition of blended phytosterols to a prudent North American diet improved plasma LDL-cholesterol concentrations by mechanisms that did not result in significant changes in endogenous cholesterol synthesis in hypercholesterolemic men.

Authors+Show Affiliations

School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal. Jonesp@agradm.lan.mcgill.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10357732

Citation

Jones, P J., et al. "Cholesterol-lowering Efficacy of a Sitostanol-containing Phytosterol Mixture With a Prudent Diet in Hyperlipidemic Men." The American Journal of Clinical Nutrition, vol. 69, no. 6, 1999, pp. 1144-50.
Jones PJ, Ntanios FY, Raeini-Sarjaz M, et al. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am J Clin Nutr. 1999;69(6):1144-50.
Jones, P. J., Ntanios, F. Y., Raeini-Sarjaz, M., & Vanstone, C. A. (1999). Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. The American Journal of Clinical Nutrition, 69(6), 1144-50.
Jones PJ, et al. Cholesterol-lowering Efficacy of a Sitostanol-containing Phytosterol Mixture With a Prudent Diet in Hyperlipidemic Men. Am J Clin Nutr. 1999;69(6):1144-50. PubMed PMID: 10357732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. AU - Jones,P J, AU - Ntanios,F Y, AU - Raeini-Sarjaz,M, AU - Vanstone,C A, PY - 1999/6/5/pubmed PY - 1999/6/5/medline PY - 1999/6/5/entrez SP - 1144 EP - 50 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 69 IS - 6 N2 - BACKGROUND: Dietary plant sterols (phytosterols) have been shown to lower plasma lipid concentrations in animals and humans. However, the effect of phytosterol intake from tall oil on cholesterol and phytosterol metabolism has not been assessed in subjects fed precisely controlled diets. OBJECTIVE: Our objective was to examine the effects of sitostanol-containing phytosterols on plasma lipid and phytosterol concentrations and de novo cholesterol synthesis rate in the context of a controlled diet. DESIGN: Thirty-two hypercholesterolemic men were fed either a diet of prepared foods alone or a diet containing 1.7 g phytosterols/d for 30 d in a parallel study design. RESULTS: No overall effects of diet on total cholesterol concentrations were observed, although concentrations were lower with the phytosterol-enriched than with the control diet on day 30 (P < 0.05). LDL-cholesterol concentrations on day 30 had decreased by 8.9% (P < 0.01) and 24.4% (P < 0.001) with the control and phytosterol-enriched diets, respectively. HDL-cholesterol and triacylglycerol concentrations did not change significantly. Moreover, changes in circulating campesterol and beta-sitosterol concentrations were not significantly different between phytosterol-fed and control subjects. In addition, there were no significant differences in fractional (0.091 +/- 0.028 and 0.091 +/- 0.026 pool/d, respectively) or absolute (0.61 +/- 0.24 and 0.65 +/- 0.23 g/d, respectively) synthesis rates of cholesterol observed between control and phytosterol-fed subjects. CONCLUSION: Addition of blended phytosterols to a prudent North American diet improved plasma LDL-cholesterol concentrations by mechanisms that did not result in significant changes in endogenous cholesterol synthesis in hypercholesterolemic men. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/10357732/Cholesterol_lowering_efficacy_of_a_sitostanol_containing_phytosterol_mixture_with_a_prudent_diet_in_hyperlipidemic_men_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/69.6.1144 DB - PRIME DP - Unbound Medicine ER -