Tags

Type your tag names separated by a space and hit enter

The biological basis for the attenuation of mucositis: the example of interleukin-11.
Leukemia 1999; 13(6):831-4L

Abstract

Oral mucositis is common, painful, dose-limiting toxicity of drug and radiation therapy for cancer. In granulocytopenic patients, the ulcerations which accompany mucositis are frequent portals of entry for indigenous oral bacteria often leading to bacteremias or sepsis. The complexity of mucositis as a biological process has only recently been appreciated. The condition appears to represent a sequential interaction of the oral mucosal cells and tissues, pro-inflammatory cytokines, and local environmental factors in the mouth such as microorganisms and saliva. The recognition that the pathophysiology of mucositis is a multifactorial process has presented opportunities for intervention based on biological attenuation. Interleukin-11, a pleotropic cytokine, has a range of activities which is potentially relevant to mucositis. Consequently, it has been used successfully to modify the development, severity and course of mucositis in an animal model which closely mimics the equivalent human condition.

Authors+Show Affiliations

Division of Oral Medicine, Oral and Maxillofacial Surgery and Dentistry, Brigham and Women's Hospital, Boston, MA 02115, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10360368

Citation

Sonis, S, et al. "The Biological Basis for the Attenuation of Mucositis: the Example of Interleukin-11." Leukemia, vol. 13, no. 6, 1999, pp. 831-4.
Sonis S, Edwards L, Lucey C. The biological basis for the attenuation of mucositis: the example of interleukin-11. Leukemia. 1999;13(6):831-4.
Sonis, S., Edwards, L., & Lucey, C. (1999). The biological basis for the attenuation of mucositis: the example of interleukin-11. Leukemia, 13(6), pp. 831-4.
Sonis S, Edwards L, Lucey C. The Biological Basis for the Attenuation of Mucositis: the Example of Interleukin-11. Leukemia. 1999;13(6):831-4. PubMed PMID: 10360368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The biological basis for the attenuation of mucositis: the example of interleukin-11. AU - Sonis,S, AU - Edwards,L, AU - Lucey,C, PY - 1999/6/9/pubmed PY - 1999/6/9/medline PY - 1999/6/9/entrez SP - 831 EP - 4 JF - Leukemia JO - Leukemia VL - 13 IS - 6 N2 - Oral mucositis is common, painful, dose-limiting toxicity of drug and radiation therapy for cancer. In granulocytopenic patients, the ulcerations which accompany mucositis are frequent portals of entry for indigenous oral bacteria often leading to bacteremias or sepsis. The complexity of mucositis as a biological process has only recently been appreciated. The condition appears to represent a sequential interaction of the oral mucosal cells and tissues, pro-inflammatory cytokines, and local environmental factors in the mouth such as microorganisms and saliva. The recognition that the pathophysiology of mucositis is a multifactorial process has presented opportunities for intervention based on biological attenuation. Interleukin-11, a pleotropic cytokine, has a range of activities which is potentially relevant to mucositis. Consequently, it has been used successfully to modify the development, severity and course of mucositis in an animal model which closely mimics the equivalent human condition. SN - 0887-6924 UR - https://www.unboundmedicine.com/medline/citation/10360368/The_biological_basis_for_the_attenuation_of_mucositis:_the_example_of_interleukin_11_ L2 - http://dx.doi.org/10.1038/sj.leu.2401441 DB - PRIME DP - Unbound Medicine ER -