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Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue.
Dement Geriatr Cogn Disord 1999 Jul-Aug; 10(4):252-7DG

Abstract

Significantly increased glial fibrillary acidic protein (GFAP) expression was seen in postmortem brain tissue from demented patients with Alzheimer's disease (AD) (73 cases, 61 females/12 males, mean age 84 +/- 9 years) compared to controls (22 cases, 10 females/12 males, mean age 78 +/- 9 years). In demented patients, the GFAP expression, counts of AD lesions, senile/neuritic plaques (SP/NP) and neurofibrillary tangles (NFT) were higher in patients carrying the apolipoprotein E (ApoE) epsilon4 allele compared to those without the ApoE epsilon4 allele. The astrogliosis correlated significantly with the counts of NFT in demented patients both with and without the ApoE epsilon4 allele. Furthermore, the astrogliosis correlated significantly with the counts of SP/NP, but this correlation, however, was influenced by the ApoE epsilon4 allele, being significant only in those cases without the ApoE epsilon4 allele. Our results demonstrate that not only the extent of AD lesions and GFAP expression, but also the relationship between AD lesions and the GFAP expression is influenced by the ApoE epsilon4 allele.

Authors+Show Affiliations

Department of Neuroscience and Neurology, Kuopio University Hospital, Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10364641

Citation

Overmyer, M, et al. "Astrogliosis and the ApoE Genotype. an Immunohistochemical Study of Postmortem Human Brain Tissue." Dementia and Geriatric Cognitive Disorders, vol. 10, no. 4, 1999, pp. 252-7.
Overmyer M, Helisalmi S, Soininen H, et al. Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue. Dement Geriatr Cogn Disord. 1999;10(4):252-7.
Overmyer, M., Helisalmi, S., Soininen, H., Laakso, M., Riekkinen, P., & Alafuzoff, I. (1999). Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue. Dementia and Geriatric Cognitive Disorders, 10(4), pp. 252-7.
Overmyer M, et al. Astrogliosis and the ApoE Genotype. an Immunohistochemical Study of Postmortem Human Brain Tissue. Dement Geriatr Cogn Disord. 1999;10(4):252-7. PubMed PMID: 10364641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue. AU - Overmyer,M, AU - Helisalmi,S, AU - Soininen,H, AU - Laakso,M, AU - Riekkinen,P,Sr AU - Alafuzoff,I, PY - 1999/6/12/pubmed PY - 2001/3/28/medline PY - 1999/6/12/entrez SP - 252 EP - 7 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 10 IS - 4 N2 - Significantly increased glial fibrillary acidic protein (GFAP) expression was seen in postmortem brain tissue from demented patients with Alzheimer's disease (AD) (73 cases, 61 females/12 males, mean age 84 +/- 9 years) compared to controls (22 cases, 10 females/12 males, mean age 78 +/- 9 years). In demented patients, the GFAP expression, counts of AD lesions, senile/neuritic plaques (SP/NP) and neurofibrillary tangles (NFT) were higher in patients carrying the apolipoprotein E (ApoE) epsilon4 allele compared to those without the ApoE epsilon4 allele. The astrogliosis correlated significantly with the counts of NFT in demented patients both with and without the ApoE epsilon4 allele. Furthermore, the astrogliosis correlated significantly with the counts of SP/NP, but this correlation, however, was influenced by the ApoE epsilon4 allele, being significant only in those cases without the ApoE epsilon4 allele. Our results demonstrate that not only the extent of AD lesions and GFAP expression, but also the relationship between AD lesions and the GFAP expression is influenced by the ApoE epsilon4 allele. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/10364641/Astrogliosis_and_the_ApoE_genotype__an_immunohistochemical_study_of_postmortem_human_brain_tissue_ L2 - https://www.karger.com?DOI=10.1159/000017128 DB - PRIME DP - Unbound Medicine ER -