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Weight loss has an independent beneficial effect on symptoms of gastro-oesophageal reflux in patients who are overweight.
Scand J Gastroenterol 1999; 34(4):337-40SJ

Abstract

BACKGROUND

Weight loss is commonly recommended as part of first-line management of gastrooesophageal reflux disease (GORD) despite the paucity of published clinical trials. The aim of this study was to prospectively assess the independent effect of weight loss on reflux symptoms in overweight individuals with either normal endoscopic findings or grade-I oesophagitis.

METHODS

Thirty-four patients were recruited on the basis of a body mass index (BMI) of greater than 23 and symptoms of GORD for at least 6 months. All patients were advised to lose weight. Symptoms of gastro-oesophageal reflux (GOR) were scored, using a modified DeMeester questionnaire at 0, 6, and 26 weeks. Patients who were unable to stop taking all medication for control of symptoms were excluded from the study. Changes in weight and symptom score were analysed by using a paired t test. Correlation between change in weight and symptom score was assessed with the Pearson correlation test.

RESULTS

Thirty-four patients were studied (18 men and 16 women) with a mean age of 65 years (range, 24-70 years). The mean weight at recruitment was 83.4 kg (standard deviation (s), 4.5 kg; BMI, 23.5 kg/m2 (s, 2.3 kg/m2). Twenty-seven patients (80% of the total) lost weight with a mean of 4.0 kg (P < 0.01) and improved by a mean reduction of 75% from the initial symptom score (P < 0.001). In nine patients the symptoms disappeared completely. Three patients gained weight and had a deterioration of their symptoms, whereas four patients gained weight but still improved their symptom score. There was a significant direct correlation between weight loss and symptom score (R = 0.548, P < 0.001).

CONCLUSIONS

This study has shown a significant association between weight loss and improvement in symptoms of GOR. Patients who are overweight should be encouraged to lose weight as part of the first-line management.

Authors+Show Affiliations

Dept. of Gastroenterology, Derbyshire Royal Infirmary NHS Trust, Derby, England.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10365891

Citation

Fraser-Moodie, C A., et al. "Weight Loss Has an Independent Beneficial Effect On Symptoms of Gastro-oesophageal Reflux in Patients Who Are Overweight." Scandinavian Journal of Gastroenterology, vol. 34, no. 4, 1999, pp. 337-40.
Fraser-Moodie CA, Norton B, Gornall C, et al. Weight loss has an independent beneficial effect on symptoms of gastro-oesophageal reflux in patients who are overweight. Scand J Gastroenterol. 1999;34(4):337-40.
Fraser-Moodie, C. A., Norton, B., Gornall, C., Magnago, S., Weale, A. R., & Holmes, G. K. (1999). Weight loss has an independent beneficial effect on symptoms of gastro-oesophageal reflux in patients who are overweight. Scandinavian Journal of Gastroenterology, 34(4), pp. 337-40.
Fraser-Moodie CA, et al. Weight Loss Has an Independent Beneficial Effect On Symptoms of Gastro-oesophageal Reflux in Patients Who Are Overweight. Scand J Gastroenterol. 1999;34(4):337-40. PubMed PMID: 10365891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight loss has an independent beneficial effect on symptoms of gastro-oesophageal reflux in patients who are overweight. AU - Fraser-Moodie,C A, AU - Norton,B, AU - Gornall,C, AU - Magnago,S, AU - Weale,A R, AU - Holmes,G K, PY - 1999/6/12/pubmed PY - 1999/6/12/medline PY - 1999/6/12/entrez SP - 337 EP - 40 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 34 IS - 4 N2 - BACKGROUND: Weight loss is commonly recommended as part of first-line management of gastrooesophageal reflux disease (GORD) despite the paucity of published clinical trials. The aim of this study was to prospectively assess the independent effect of weight loss on reflux symptoms in overweight individuals with either normal endoscopic findings or grade-I oesophagitis. METHODS: Thirty-four patients were recruited on the basis of a body mass index (BMI) of greater than 23 and symptoms of GORD for at least 6 months. All patients were advised to lose weight. Symptoms of gastro-oesophageal reflux (GOR) were scored, using a modified DeMeester questionnaire at 0, 6, and 26 weeks. Patients who were unable to stop taking all medication for control of symptoms were excluded from the study. Changes in weight and symptom score were analysed by using a paired t test. Correlation between change in weight and symptom score was assessed with the Pearson correlation test. RESULTS: Thirty-four patients were studied (18 men and 16 women) with a mean age of 65 years (range, 24-70 years). The mean weight at recruitment was 83.4 kg (standard deviation (s), 4.5 kg; BMI, 23.5 kg/m2 (s, 2.3 kg/m2). Twenty-seven patients (80% of the total) lost weight with a mean of 4.0 kg (P < 0.01) and improved by a mean reduction of 75% from the initial symptom score (P < 0.001). In nine patients the symptoms disappeared completely. Three patients gained weight and had a deterioration of their symptoms, whereas four patients gained weight but still improved their symptom score. There was a significant direct correlation between weight loss and symptom score (R = 0.548, P < 0.001). CONCLUSIONS: This study has shown a significant association between weight loss and improvement in symptoms of GOR. Patients who are overweight should be encouraged to lose weight as part of the first-line management. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/10365891/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/003655299750026326 DB - PRIME DP - Unbound Medicine ER -