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Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case-control study.

Abstract

BACKGROUND

Helicobacter pylori infection is an established risk factor for gastric adenocarcinoma. Potential confounding by socioeconomic factors has not been adequately assessed, and the magnitude of the relative risk in relation to gastric subsites, morphologic subtypes, sex, age, and follow-up time need further study.

METHODS

We conducted a serologic case-control study nested within the Norwegian JANUS cohort. Between 1972 and 1986 serum was collected from 101,601 subjects who were followed up with regard to cancer development through 1992.

RESULTS

Among 208 gastric adenocarcinoma cases, we found a strong positive association between H. pylori infection and non-cardia gastric cancer (odds ratio (OR), 5.15; 95% confidence interval (CI), 2.83-9.37), and a statistically significant negative association with cardia cancer (OR, 0.40; 95% CI, 0.20-0.77). Adjustment for socioeconomic factors and smoking did not materially alter the effect estimates. The association between the infection and non-cardia cancer was stronger for tumors distal to the angulus and tended to be stronger in women than in men. The results were similar across Laurén morphologic subtypes.

CONCLUSIONS

These results strengthen the evidence of H. pylori infection as a risk factor in non-cardia gastric cancer. A negative association with H. pylori infection was found for cardia cancer.

Authors+Show Affiliations

,

Cancer Registry of Norway, Dept. of Microbiology, Ullevål University Hospital, Oslo.

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Source

MeSH

Adenocarcinoma
Cardia
Case-Control Studies
Female
Helicobacter Infections
Helicobacter pylori
Humans
Male
Middle Aged
Norway
Risk Factors
Smoking
Socioeconomic Factors
Stomach Neoplasms

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10365894

Citation

Hansen, S, et al. "Helicobacter Pylori Infection and Risk of Cardia Cancer and Non-cardia Gastric Cancer. a Nested Case-control Study." Scandinavian Journal of Gastroenterology, vol. 34, no. 4, 1999, pp. 353-60.
Hansen S, Melby KK, Aase S, et al. Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case-control study. Scand J Gastroenterol. 1999;34(4):353-60.
Hansen, S., Melby, K. K., Aase, S., Jellum, E., & Vollset, S. E. (1999). Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case-control study. Scandinavian Journal of Gastroenterology, 34(4), pp. 353-60.
Hansen S, et al. Helicobacter Pylori Infection and Risk of Cardia Cancer and Non-cardia Gastric Cancer. a Nested Case-control Study. Scand J Gastroenterol. 1999;34(4):353-60. PubMed PMID: 10365894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case-control study. AU - Hansen,S, AU - Melby,K K, AU - Aase,S, AU - Jellum,E, AU - Vollset,S E, PY - 1999/6/12/pubmed PY - 1999/6/12/medline PY - 1999/6/12/entrez SP - 353 EP - 60 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 34 IS - 4 N2 - BACKGROUND: Helicobacter pylori infection is an established risk factor for gastric adenocarcinoma. Potential confounding by socioeconomic factors has not been adequately assessed, and the magnitude of the relative risk in relation to gastric subsites, morphologic subtypes, sex, age, and follow-up time need further study. METHODS: We conducted a serologic case-control study nested within the Norwegian JANUS cohort. Between 1972 and 1986 serum was collected from 101,601 subjects who were followed up with regard to cancer development through 1992. RESULTS: Among 208 gastric adenocarcinoma cases, we found a strong positive association between H. pylori infection and non-cardia gastric cancer (odds ratio (OR), 5.15; 95% confidence interval (CI), 2.83-9.37), and a statistically significant negative association with cardia cancer (OR, 0.40; 95% CI, 0.20-0.77). Adjustment for socioeconomic factors and smoking did not materially alter the effect estimates. The association between the infection and non-cardia cancer was stronger for tumors distal to the angulus and tended to be stronger in women than in men. The results were similar across Laurén morphologic subtypes. CONCLUSIONS: These results strengthen the evidence of H. pylori infection as a risk factor in non-cardia gastric cancer. A negative association with H. pylori infection was found for cardia cancer. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/10365894/Helicobacter_pylori_infection_and_risk_of_cardia_cancer_and_non_cardia_gastric_cancer__A_nested_case_control_study_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -