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Finasteride in the treatment of men with frontal male pattern hair loss.
J Am Acad Dermatol. 1999 Jun; 40(6 Pt 1):930-7.JA

Abstract

BACKGROUND

Finasteride, a specific inhibitor of type II 5alpha-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss.

OBJECTIVE

This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning.

METHODS

This was a 1-year, double-blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review.

RESULTS

There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated.

CONCLUSION

In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.

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Publisher Full Text

Authors+Show Affiliations

Leyden J
University of Pennsylvania School of Medicine, Philadelphia, USA.
Dunlap F
No affiliation info available
Miller B
No affiliation info available
Winters P
No affiliation info available
Lebwohl M
No affiliation info available
Hecker D
No affiliation info available
Kraus S
No affiliation info available
Baldwin H
No affiliation info available
Shalita A
No affiliation info available
Draelos Z
No affiliation info available
Markou M
No affiliation info available
Thiboutot D
No affiliation info available
Rapaport M
No affiliation info available
Kang S
No affiliation info available
Kelly T
No affiliation info available
Pariser D
No affiliation info available
Webster G
No affiliation info available
Hordinsky M
No affiliation info available
Rietschel R
No affiliation info available
Katz HI
No affiliation info available
Terranella L
No affiliation info available
Best S
No affiliation info available
Round E
No affiliation info available
Waldstreicher J
No affiliation info available

MeSH

5-alpha Reductase InhibitorsAdultAlopeciaDouble-Blind MethodEnzyme InhibitorsFinasterideHairHumansMalePatient Satisfaction

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10365924

Citation

Leyden, J, et al. "Finasteride in the Treatment of Men With Frontal Male Pattern Hair Loss." Journal of the American Academy of Dermatology, vol. 40, no. 6 Pt 1, 1999, pp. 930-7.
Leyden J, Dunlap F, Miller B, et al. Finasteride in the treatment of men with frontal male pattern hair loss. J Am Acad Dermatol. 1999;40(6 Pt 1):930-7.
Leyden, J., Dunlap, F., Miller, B., Winters, P., Lebwohl, M., Hecker, D., Kraus, S., Baldwin, H., Shalita, A., Draelos, Z., Markou, M., Thiboutot, D., Rapaport, M., Kang, S., Kelly, T., Pariser, D., Webster, G., Hordinsky, M., Rietschel, R., ... Waldstreicher, J. (1999). Finasteride in the treatment of men with frontal male pattern hair loss. Journal of the American Academy of Dermatology, 40(6 Pt 1), 930-7.
Leyden J, et al. Finasteride in the Treatment of Men With Frontal Male Pattern Hair Loss. J Am Acad Dermatol. 1999;40(6 Pt 1):930-7. PubMed PMID: 10365924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Finasteride in the treatment of men with frontal male pattern hair loss. AU - Leyden,J, AU - Dunlap,F, AU - Miller,B, AU - Winters,P, AU - Lebwohl,M, AU - Hecker,D, AU - Kraus,S, AU - Baldwin,H, AU - Shalita,A, AU - Draelos,Z, AU - Markou,M, AU - Thiboutot,D, AU - Rapaport,M, AU - Kang,S, AU - Kelly,T, AU - Pariser,D, AU - Webster,G, AU - Hordinsky,M, AU - Rietschel,R, AU - Katz,H I, AU - Terranella,L, AU - Best,S, AU - Round,E, AU - Waldstreicher,J, PY - 1999/6/12/pubmed PY - 1999/6/12/medline PY - 1999/6/12/entrez SP - 930 EP - 7 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 40 IS - 6 Pt 1 N2 - BACKGROUND: Finasteride, a specific inhibitor of type II 5alpha-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss. OBJECTIVE: This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning. METHODS: This was a 1-year, double-blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review. RESULTS: There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated. CONCLUSION: In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/10365924/Finasteride_in_the_treatment_of_men_with_frontal_male_pattern_hair_loss_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(99)70081-2 DB - PRIME DP - Unbound Medicine ER -