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Plasma volume changes during and after acute variations of body hydration level in humans.
Eur J Appl Physiol Occup Physiol. 1999 Jun; 80(1):1-8.EJ

Abstract

This study examined plasma volume changes (deltaPV) in humans during periods with or without changes in body hydration: exercise-induced dehydration, heat-induced dehydration and glycerol hyperhydration. Repeated measurements of plasma volume were made after two injections of Evans blue. Results were compared to deltaPV calculated from haematocrit (Hct) and blood haemoglobin concentration ([Hb]). Eight well-trained men completed four trials in randomized order: euhydration (control test C), 2.8% dehydration of body mass by passive controlled hyperthermia (D) and by treadmill exercise (60% of their maximal oxygen uptake, VO2max) (E), and hyperhydration (H) by glycerol ingestion. The Hct, [Hb], plasma protein concentrations and plasma osmolality were measured before, during and after the changes in body hydration. Different Hct and [Hb] reference values were obtained to allow for posture-induced variations between and during trials. The deltaPV values calculated after two Evans blue injections were in good agreement with deltaPV calculated from Hct and [Hb]. Compared to the control test, mean plasma volume declined markedly during heat-induced dehydration [-11.4 (SEM 1.7)%] and slightly during exercise-induced dehydration [-4.2 (SEM 0.9)%] (P < 0.001 compared to D), although hyperosmolality was similar in these two trials. Conversely, glycerol hyperhydration induced an increase in plasma volume [+7.5 (SEM 1.0)%]. These results would indicate that, for a given level of dehydration, plasma volume is dramatically decreased during and after heat exposure, while it is better maintained during and after exercise.

Authors+Show Affiliations

Unité de Bioénergétique et Environnement, Centre de Recherches du Service de Santé des Armées Emile Pardé, La Tronche, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10367716

Citation

Jimenez, C, et al. "Plasma Volume Changes During and After Acute Variations of Body Hydration Level in Humans." European Journal of Applied Physiology and Occupational Physiology, vol. 80, no. 1, 1999, pp. 1-8.
Jimenez C, Melin B, Koulmann N, et al. Plasma volume changes during and after acute variations of body hydration level in humans. Eur J Appl Physiol Occup Physiol. 1999;80(1):1-8.
Jimenez, C., Melin, B., Koulmann, N., Allevard, A. M., Launay, J. C., & Savourey, G. (1999). Plasma volume changes during and after acute variations of body hydration level in humans. European Journal of Applied Physiology and Occupational Physiology, 80(1), 1-8.
Jimenez C, et al. Plasma Volume Changes During and After Acute Variations of Body Hydration Level in Humans. Eur J Appl Physiol Occup Physiol. 1999;80(1):1-8. PubMed PMID: 10367716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma volume changes during and after acute variations of body hydration level in humans. AU - Jimenez,C, AU - Melin,B, AU - Koulmann,N, AU - Allevard,A M, AU - Launay,J C, AU - Savourey,G, PY - 1999/6/15/pubmed PY - 1999/6/15/medline PY - 1999/6/15/entrez SP - 1 EP - 8 JF - European journal of applied physiology and occupational physiology JO - Eur J Appl Physiol Occup Physiol VL - 80 IS - 1 N2 - This study examined plasma volume changes (deltaPV) in humans during periods with or without changes in body hydration: exercise-induced dehydration, heat-induced dehydration and glycerol hyperhydration. Repeated measurements of plasma volume were made after two injections of Evans blue. Results were compared to deltaPV calculated from haematocrit (Hct) and blood haemoglobin concentration ([Hb]). Eight well-trained men completed four trials in randomized order: euhydration (control test C), 2.8% dehydration of body mass by passive controlled hyperthermia (D) and by treadmill exercise (60% of their maximal oxygen uptake, VO2max) (E), and hyperhydration (H) by glycerol ingestion. The Hct, [Hb], plasma protein concentrations and plasma osmolality were measured before, during and after the changes in body hydration. Different Hct and [Hb] reference values were obtained to allow for posture-induced variations between and during trials. The deltaPV values calculated after two Evans blue injections were in good agreement with deltaPV calculated from Hct and [Hb]. Compared to the control test, mean plasma volume declined markedly during heat-induced dehydration [-11.4 (SEM 1.7)%] and slightly during exercise-induced dehydration [-4.2 (SEM 0.9)%] (P < 0.001 compared to D), although hyperosmolality was similar in these two trials. Conversely, glycerol hyperhydration induced an increase in plasma volume [+7.5 (SEM 1.0)%]. These results would indicate that, for a given level of dehydration, plasma volume is dramatically decreased during and after heat exposure, while it is better maintained during and after exercise. SN - 0301-5548 UR - https://www.unboundmedicine.com/medline/citation/10367716/Plasma_volume_changes_during_and_after_acute_variations_of_body_hydration_level_in_humans_ L2 - https://medlineplus.gov/dehydration.html DB - PRIME DP - Unbound Medicine ER -