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Bromperidol, a new potent neuroleptic of the butyrophenone series. A comparison of the effects of bromperidol and haloperidol in intracranial self-stimulation.
Arzneimittelforschung. 1976; 26(7):1356-9.A

Abstract

Bromperidol, a new potent and long-acting neuroleptic of the butyrophenone series, and haloperidol were injected s.c. at the doses 0.01, 0.02, 0.04 and 0.08 mg/kg, in rats implanted with electrodes in the lateral hypothalamic region of the medial forebrain bundle. A dose-related response inhibition was found with both compounds and the graphically estimated ED50 value was 0.041 mg/kg for bromperidol and 0.047 mg/kg for haloperidol. These data are in complete agreement with our previous findings that bromperidol is a new potent and specific neuroleptic.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1036924

Citation

Wauquier, A, and C J. Niemegeers. "Bromperidol, a New Potent Neuroleptic of the Butyrophenone Series. a Comparison of the Effects of Bromperidol and Haloperidol in Intracranial Self-stimulation." Arzneimittel-Forschung, vol. 26, no. 7, 1976, pp. 1356-9.
Wauquier A, Niemegeers CJ. Bromperidol, a new potent neuroleptic of the butyrophenone series. A comparison of the effects of bromperidol and haloperidol in intracranial self-stimulation. Arzneimittelforschung. 1976;26(7):1356-9.
Wauquier, A., & Niemegeers, C. J. (1976). Bromperidol, a new potent neuroleptic of the butyrophenone series. A comparison of the effects of bromperidol and haloperidol in intracranial self-stimulation. Arzneimittel-Forschung, 26(7), 1356-9.
Wauquier A, Niemegeers CJ. Bromperidol, a New Potent Neuroleptic of the Butyrophenone Series. a Comparison of the Effects of Bromperidol and Haloperidol in Intracranial Self-stimulation. Arzneimittelforschung. 1976;26(7):1356-9. PubMed PMID: 1036924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bromperidol, a new potent neuroleptic of the butyrophenone series. A comparison of the effects of bromperidol and haloperidol in intracranial self-stimulation. AU - Wauquier,A, AU - Niemegeers,C J, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 1356 EP - 9 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 26 IS - 7 N2 - Bromperidol, a new potent and long-acting neuroleptic of the butyrophenone series, and haloperidol were injected s.c. at the doses 0.01, 0.02, 0.04 and 0.08 mg/kg, in rats implanted with electrodes in the lateral hypothalamic region of the medial forebrain bundle. A dose-related response inhibition was found with both compounds and the graphically estimated ED50 value was 0.041 mg/kg for bromperidol and 0.047 mg/kg for haloperidol. These data are in complete agreement with our previous findings that bromperidol is a new potent and specific neuroleptic. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/1036924/Bromperidol_a_new_potent_neuroleptic_of_the_butyrophenone_series__A_comparison_of_the_effects_of_bromperidol_and_haloperidol_in_intracranial_self_stimulation_ DB - PRIME DP - Unbound Medicine ER -