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Properties of solid dispersions of piroxicam in polyvinylpyrrolidone.
Int J Pharm. 1999 Apr 30; 181(2):143-51.IJ

Abstract

Solid dispersions of piroxicam were prepared with polyvinylpyrrolidone (PVP) K-17 PF and PVP K-90 by solvent method. The physical state and drug:PVP interaction of solid dispersions and physical mixtures were characterized by X-ray diffraction, Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). FTIR analysis demonstrated the presence of intermolecular hydrogen bonding between piroxicam and PVP in solid dispersions. These interactions reflected the changes in crystalline structures of piroxicam. The amorphousness within the PVP moeity might be predicted in piroxicam dispersions by the disappearance of N-H or O-H peak of piroxicam. Dissolution studies indicated a significant increase in dissolution of piroxicam when dispersed in PVP. The better results were obtained with the lower molecular weight PVP K-17 than with higher molecular weight PVP K-90. The non-amorphous solid dispersions in PVP K-17 showed almost equally fast dissolution rates to amorphous dispersions in PVP K-90. The mechanism of dissolution of solid dispersion in PVP K-90 is predominantly diffusion-controlled due to the very high viscosity of PVP K-90. Dissolution was maximum with the amorphous solid dispersions containing drug:PVP K-17 1:5 and 1:6 which showed a 40-fold increase in dissolution in 5 min as compared with pure drug.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90110, Thailand. tvinom@ratree.psu.ac.thNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10370210

Citation

Tantishaiyakul, V, et al. "Properties of Solid Dispersions of Piroxicam in Polyvinylpyrrolidone." International Journal of Pharmaceutics, vol. 181, no. 2, 1999, pp. 143-51.
Tantishaiyakul V, Kaewnopparat N, Ingkatawornwong S. Properties of solid dispersions of piroxicam in polyvinylpyrrolidone. Int J Pharm. 1999;181(2):143-51.
Tantishaiyakul, V., Kaewnopparat, N., & Ingkatawornwong, S. (1999). Properties of solid dispersions of piroxicam in polyvinylpyrrolidone. International Journal of Pharmaceutics, 181(2), 143-51.
Tantishaiyakul V, Kaewnopparat N, Ingkatawornwong S. Properties of Solid Dispersions of Piroxicam in Polyvinylpyrrolidone. Int J Pharm. 1999 Apr 30;181(2):143-51. PubMed PMID: 10370210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Properties of solid dispersions of piroxicam in polyvinylpyrrolidone. AU - Tantishaiyakul,V, AU - Kaewnopparat,N, AU - Ingkatawornwong,S, PY - 1999/6/17/pubmed PY - 1999/6/17/medline PY - 1999/6/17/entrez SP - 143 EP - 51 JF - International journal of pharmaceutics JO - Int J Pharm VL - 181 IS - 2 N2 - Solid dispersions of piroxicam were prepared with polyvinylpyrrolidone (PVP) K-17 PF and PVP K-90 by solvent method. The physical state and drug:PVP interaction of solid dispersions and physical mixtures were characterized by X-ray diffraction, Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). FTIR analysis demonstrated the presence of intermolecular hydrogen bonding between piroxicam and PVP in solid dispersions. These interactions reflected the changes in crystalline structures of piroxicam. The amorphousness within the PVP moeity might be predicted in piroxicam dispersions by the disappearance of N-H or O-H peak of piroxicam. Dissolution studies indicated a significant increase in dissolution of piroxicam when dispersed in PVP. The better results were obtained with the lower molecular weight PVP K-17 than with higher molecular weight PVP K-90. The non-amorphous solid dispersions in PVP K-17 showed almost equally fast dissolution rates to amorphous dispersions in PVP K-90. The mechanism of dissolution of solid dispersion in PVP K-90 is predominantly diffusion-controlled due to the very high viscosity of PVP K-90. Dissolution was maximum with the amorphous solid dispersions containing drug:PVP K-17 1:5 and 1:6 which showed a 40-fold increase in dissolution in 5 min as compared with pure drug. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/10370210/Properties_of_solid_dispersions_of_piroxicam_in_polyvinylpyrrolidone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378517399000708 DB - PRIME DP - Unbound Medicine ER -