Tags

Type your tag names separated by a space and hit enter

Molecular and phenotypic markers of hamartomatous polyposis syndromes in the gastrointestinal tract.
Hepatogastroenterology. 1999 Mar-Apr; 46(26):661-6.H

Abstract

Hamartomatous gastrointestinal polyposis syndromes have always been considered as non-neoplastic. Nevertheless, an increased cancer risk both within and outside the gastrointestinal tract may exist in these syndromes. The hamartomatous polyps may sometimes harbor dysplasia, but their neoplastic potential is unknown. The genetic defects causing the hamartomatous syndromes are less well established than, for example, familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC). The genetic studies on the Mendelian inherited syndromes FAP and HNPCC have made a major contribution to the identification of genes involved in colorectal tumorigenesis. The genes involved in colorectal cancer development may also contribute to cancer development in the hamartomatous polyposis syndromes, and are currently under investigation. Furthermore, new insights into the development of various cancers may be obtained by the isolation and characterization of genes involved in Mendelian inherited hamartomatous polyposis syndromes. This report summarizes the available literature on this subject, and describes the pheno- and genotypic features of the hamartomatous syndromes of juvenile polyposis, Peutz-Jeghers syndrome, and Cowden's disease.

Authors+Show Affiliations

Department of Pathology, Academic Medical Centre, University of Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10370593

Citation

Entius, M M., et al. "Molecular and Phenotypic Markers of Hamartomatous Polyposis Syndromes in the Gastrointestinal Tract." Hepato-gastroenterology, vol. 46, no. 26, 1999, pp. 661-6.
Entius MM, Westerman AM, van Velthuysen ML, et al. Molecular and phenotypic markers of hamartomatous polyposis syndromes in the gastrointestinal tract. Hepatogastroenterology. 1999;46(26):661-6.
Entius, M. M., Westerman, A. M., van Velthuysen, M. L., Wilson, J. H., Hamilton, S. R., Giardiello, F. M., & Offerhaus, G. J. (1999). Molecular and phenotypic markers of hamartomatous polyposis syndromes in the gastrointestinal tract. Hepato-gastroenterology, 46(26), 661-6.
Entius MM, et al. Molecular and Phenotypic Markers of Hamartomatous Polyposis Syndromes in the Gastrointestinal Tract. Hepatogastroenterology. 1999 Mar-Apr;46(26):661-6. PubMed PMID: 10370593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular and phenotypic markers of hamartomatous polyposis syndromes in the gastrointestinal tract. AU - Entius,M M, AU - Westerman,A M, AU - van Velthuysen,M L, AU - Wilson,J H, AU - Hamilton,S R, AU - Giardiello,F M, AU - Offerhaus,G J, PY - 1999/6/17/pubmed PY - 1999/6/17/medline PY - 1999/6/17/entrez SP - 661 EP - 6 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 46 IS - 26 N2 - Hamartomatous gastrointestinal polyposis syndromes have always been considered as non-neoplastic. Nevertheless, an increased cancer risk both within and outside the gastrointestinal tract may exist in these syndromes. The hamartomatous polyps may sometimes harbor dysplasia, but their neoplastic potential is unknown. The genetic defects causing the hamartomatous syndromes are less well established than, for example, familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC). The genetic studies on the Mendelian inherited syndromes FAP and HNPCC have made a major contribution to the identification of genes involved in colorectal tumorigenesis. The genes involved in colorectal cancer development may also contribute to cancer development in the hamartomatous polyposis syndromes, and are currently under investigation. Furthermore, new insights into the development of various cancers may be obtained by the isolation and characterization of genes involved in Mendelian inherited hamartomatous polyposis syndromes. This report summarizes the available literature on this subject, and describes the pheno- and genotypic features of the hamartomatous syndromes of juvenile polyposis, Peutz-Jeghers syndrome, and Cowden's disease. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/10370593/Molecular_and_phenotypic_markers_of_hamartomatous_polyposis_syndromes_in_the_gastrointestinal_tract_ DB - PRIME DP - Unbound Medicine ER -