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Cardioprotection of red wine: role of polyphenolic antioxidants.
Drugs Exp Clin Res 1999; 25(2-3):115-20DE

Abstract

Epidemiological studies suggest that the consumption of wine, particularly of red wine, reduces the incidence of mortality and morbidity from coronary heart disease. This has given rise to what is now popularly termed the "French paradox". The cardioprotective effect has been attributed to antioxidants present in the polyphenol fraction of red wine. Grapes contain a variety of antioxidants, including resveratrol, catechin, epicatechin and proanthocyanidins. Of these, resveratrol is present mainly in grape skin while proanthocyanidin is present in the seeds. In this report, we provide evidence that red wine extract as well as resveratrol and proanthocyanidins are equally effective in reducing myocardial ischemic reperfusion injury, which suggests that these red wine polyphenolic antioxidants play a crucial role in cardioprotection.

Authors+Show Affiliations

University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10370873

Citation

Das, D K., et al. "Cardioprotection of Red Wine: Role of Polyphenolic Antioxidants." Drugs Under Experimental and Clinical Research, vol. 25, no. 2-3, 1999, pp. 115-20.
Das DK, Sato M, Ray PS, et al. Cardioprotection of red wine: role of polyphenolic antioxidants. Drugs Exp Clin Res. 1999;25(2-3):115-20.
Das, D. K., Sato, M., Ray, P. S., Maulik, G., Engelman, R. M., Bertelli, A. A., & Bertelli, A. (1999). Cardioprotection of red wine: role of polyphenolic antioxidants. Drugs Under Experimental and Clinical Research, 25(2-3), pp. 115-20.
Das DK, et al. Cardioprotection of Red Wine: Role of Polyphenolic Antioxidants. Drugs Exp Clin Res. 1999;25(2-3):115-20. PubMed PMID: 10370873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardioprotection of red wine: role of polyphenolic antioxidants. AU - Das,D K, AU - Sato,M, AU - Ray,P S, AU - Maulik,G, AU - Engelman,R M, AU - Bertelli,A A, AU - Bertelli,A, PY - 1999/6/17/pubmed PY - 1999/6/17/medline PY - 1999/6/17/entrez SP - 115 EP - 20 JF - Drugs under experimental and clinical research JO - Drugs Exp Clin Res VL - 25 IS - 2-3 N2 - Epidemiological studies suggest that the consumption of wine, particularly of red wine, reduces the incidence of mortality and morbidity from coronary heart disease. This has given rise to what is now popularly termed the "French paradox". The cardioprotective effect has been attributed to antioxidants present in the polyphenol fraction of red wine. Grapes contain a variety of antioxidants, including resveratrol, catechin, epicatechin and proanthocyanidins. Of these, resveratrol is present mainly in grape skin while proanthocyanidin is present in the seeds. In this report, we provide evidence that red wine extract as well as resveratrol and proanthocyanidins are equally effective in reducing myocardial ischemic reperfusion injury, which suggests that these red wine polyphenolic antioxidants play a crucial role in cardioprotection. SN - 0378-6501 UR - https://www.unboundmedicine.com/medline/citation/10370873/Cardioprotection_of_red_wine:_role_of_polyphenolic_antioxidants_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -