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Wine and polyphenols related to platelet aggregation and atherothrombosis.
Drugs Exp Clin Res. 1999; 25(2-3):125-31.DE

Abstract

Epidemiological studies have demonstrated an inverse correlation between moderate wine and alcohol consumption and morbidity and mortality from coronary heart disease (CHD). This protective effect has been associated with an increase in the plasma level of high density lipoprotein (HDL)-cholesterol, as it is well known that plasma HDL is inversely correlated with CHD. In addition, it has become evident that blood platelets contribute to the rate of development of atherosclerosis and CHD through several mechanisms. Recent studies have shown HDL-cholesterol levels can explain only 50% of the protective effect of alcoholic beverages. The other 50% may be partly related to decreased platelet activity. The antiplatelet activity of wine is explained not only by ethanol but also by the polyphenolic components with which red wines are richly endowed. Several studies carried out in humans and animals have shown that wine phenolics could exert their effects by reducing prostanoid synthesis from arachidonate. In addition, it has been suggested that wine phenolics could reduce platelet activity mediated by nitric oxide. Moreover, wine phenolics increase vitamin E levels while decreasing the oxidation of platelets submitted to oxidative stress. However, a rebound phenomenon of hyperaggregability is observed after acute alcohol consumption but not after wine consumption. This protection afforded by wine has been duplicated in animals with grape phenolics added to alcohol. This rebound phenomenon could explain ischemic strokes or sudden deaths known to occur after episodes of drunkenness. It appears that wine and wine phenolics in particular could significantly inhibit platelet aggregation and that this could explain, at least in part, the protective effect of red wine against atherosclerosis and coronary heart disease.

Authors+Show Affiliations

Nutrition and Health Unit, International Wine and Vine Office, Paris, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10370875

Citation

Ruf, J C.. "Wine and Polyphenols Related to Platelet Aggregation and Atherothrombosis." Drugs Under Experimental and Clinical Research, vol. 25, no. 2-3, 1999, pp. 125-31.
Ruf JC. Wine and polyphenols related to platelet aggregation and atherothrombosis. Drugs Exp Clin Res. 1999;25(2-3):125-31.
Ruf, J. C. (1999). Wine and polyphenols related to platelet aggregation and atherothrombosis. Drugs Under Experimental and Clinical Research, 25(2-3), 125-31.
Ruf JC. Wine and Polyphenols Related to Platelet Aggregation and Atherothrombosis. Drugs Exp Clin Res. 1999;25(2-3):125-31. PubMed PMID: 10370875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wine and polyphenols related to platelet aggregation and atherothrombosis. A1 - Ruf,J C, PY - 1999/6/17/pubmed PY - 1999/6/17/medline PY - 1999/6/17/entrez SP - 125 EP - 31 JF - Drugs under experimental and clinical research JO - Drugs Exp Clin Res VL - 25 IS - 2-3 N2 - Epidemiological studies have demonstrated an inverse correlation between moderate wine and alcohol consumption and morbidity and mortality from coronary heart disease (CHD). This protective effect has been associated with an increase in the plasma level of high density lipoprotein (HDL)-cholesterol, as it is well known that plasma HDL is inversely correlated with CHD. In addition, it has become evident that blood platelets contribute to the rate of development of atherosclerosis and CHD through several mechanisms. Recent studies have shown HDL-cholesterol levels can explain only 50% of the protective effect of alcoholic beverages. The other 50% may be partly related to decreased platelet activity. The antiplatelet activity of wine is explained not only by ethanol but also by the polyphenolic components with which red wines are richly endowed. Several studies carried out in humans and animals have shown that wine phenolics could exert their effects by reducing prostanoid synthesis from arachidonate. In addition, it has been suggested that wine phenolics could reduce platelet activity mediated by nitric oxide. Moreover, wine phenolics increase vitamin E levels while decreasing the oxidation of platelets submitted to oxidative stress. However, a rebound phenomenon of hyperaggregability is observed after acute alcohol consumption but not after wine consumption. This protection afforded by wine has been duplicated in animals with grape phenolics added to alcohol. This rebound phenomenon could explain ischemic strokes or sudden deaths known to occur after episodes of drunkenness. It appears that wine and wine phenolics in particular could significantly inhibit platelet aggregation and that this could explain, at least in part, the protective effect of red wine against atherosclerosis and coronary heart disease. SN - 0378-6501 UR - https://www.unboundmedicine.com/medline/citation/10370875/Wine_and_polyphenols_related_to_platelet_aggregation_and_atherothrombosis_ L2 - https://medlineplus.gov/bloodthinners.html DB - PRIME DP - Unbound Medicine ER -