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Microinfusions of flumazenil into the basolateral but not the central nucleus of the amygdala enhance memory consolidation in rats.
Neurobiol Learn Mem. 1999 Jul; 72(1):1-7.NL

Abstract

Extensive evidence indicates that benzodiazepine receptors in the amygdala are involved in regulating memory consolidation. Recent findings indicate that many other drugs and hormones influence memory through selective activation of the basolateral amygdala nucleus (BLA). This experiment examined whether the memory-modulatory effect of flumazenil, a benzodiazepine receptor antagonist, selectively involves the BLA. Bilateral microinfusions of flumazenil (12 nmol in 0.2 microl) into the BLA of rats administered immediately after training in an inhibitory avoidance task significantly enhanced 48-h retention performance whereas infusions into the central nucleus were ineffective. These findings indicate that the BLA is selectively involved in mediating flumazenil's influence on memory storage and are thus consistent with extensive evidence indicating that the BLA is involved in regulating memory consolidation.

Authors+Show Affiliations

Departamento Farmacologia, Laboratório de Fisiologia e Farmacologia do SNC, Curitiba, PR, 81.531-990, Brazil. dacunha@bio.ufpr.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10371710

Citation

Da Cunha, C, et al. "Microinfusions of Flumazenil Into the Basolateral but Not the Central Nucleus of the Amygdala Enhance Memory Consolidation in Rats." Neurobiology of Learning and Memory, vol. 72, no. 1, 1999, pp. 1-7.
Da Cunha C, Roozendaal B, Vazdarjanova A, et al. Microinfusions of flumazenil into the basolateral but not the central nucleus of the amygdala enhance memory consolidation in rats. Neurobiol Learn Mem. 1999;72(1):1-7.
Da Cunha, C., Roozendaal, B., Vazdarjanova, A., & McGaugh, J. L. (1999). Microinfusions of flumazenil into the basolateral but not the central nucleus of the amygdala enhance memory consolidation in rats. Neurobiology of Learning and Memory, 72(1), 1-7.
Da Cunha C, et al. Microinfusions of Flumazenil Into the Basolateral but Not the Central Nucleus of the Amygdala Enhance Memory Consolidation in Rats. Neurobiol Learn Mem. 1999;72(1):1-7. PubMed PMID: 10371710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microinfusions of flumazenil into the basolateral but not the central nucleus of the amygdala enhance memory consolidation in rats. AU - Da Cunha,C, AU - Roozendaal,B, AU - Vazdarjanova,A, AU - McGaugh,J L, PY - 1999/6/18/pubmed PY - 1999/6/18/medline PY - 1999/6/18/entrez SP - 1 EP - 7 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 72 IS - 1 N2 - Extensive evidence indicates that benzodiazepine receptors in the amygdala are involved in regulating memory consolidation. Recent findings indicate that many other drugs and hormones influence memory through selective activation of the basolateral amygdala nucleus (BLA). This experiment examined whether the memory-modulatory effect of flumazenil, a benzodiazepine receptor antagonist, selectively involves the BLA. Bilateral microinfusions of flumazenil (12 nmol in 0.2 microl) into the BLA of rats administered immediately after training in an inhibitory avoidance task significantly enhanced 48-h retention performance whereas infusions into the central nucleus were ineffective. These findings indicate that the BLA is selectively involved in mediating flumazenil's influence on memory storage and are thus consistent with extensive evidence indicating that the BLA is involved in regulating memory consolidation. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/10371710/Microinfusions_of_flumazenil_into_the_basolateral_but_not_the_central_nucleus_of_the_amygdala_enhance_memory_consolidation_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(99)93912-6 DB - PRIME DP - Unbound Medicine ER -