Tags

Type your tag names separated by a space and hit enter

Clenbuterol administration into the basolateral amygdala post-training enhances retention in an inhibitory avoidance task.
Neurobiol Learn Mem. 1999 Jul; 72(1):8-12.NL

Abstract

The present study examined the effects of post-training infusions of the specific beta2-adrenergic agonist clenbuterol into the basolateral nucleus of the amygdala (BLA), on inhibitory avoidance retention. Male Sprague-Dawley rats were surgically implanted with cannulae aimed at the BLA. Animals were microinfused with different doses of clenbuterol (from 1.0 to 1000.0 ng) immediately after training, and retention was tested 48 h later. Clenbuterol dose dependently affected retention performances. Whereas the 10.0-ng dose of clenbuterol induced a significant increase in the performances, the groups injected with the other doses (1.0, 100.0, and 1000.0 ng) of clenbuterol did not differ from the vehicle-injected animals. These findings, indicating that clenbuterol enhanced retention of the inhibitory avoidance task, are in agreement with previous evidence showing that the adrenergic system of the amygdala is involved in the modulation of memory. Moreover, our data support the hypothesis that the memory-modulating effect of the amygdala adrenergic system is mediated, at least in part, by the activation of the beta-adrenoceptors in the BLA. These findings provide further evidence that the BLA is an important brain region in integrating hormonal influences on memory storage.

Authors+Show Affiliations

Department of Neurobiology and Behavior, University of California, Irvine, California 92697-3800, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10371711

Citation

Ferry, B, and J L. McGaugh. "Clenbuterol Administration Into the Basolateral Amygdala Post-training Enhances Retention in an Inhibitory Avoidance Task." Neurobiology of Learning and Memory, vol. 72, no. 1, 1999, pp. 8-12.
Ferry B, McGaugh JL. Clenbuterol administration into the basolateral amygdala post-training enhances retention in an inhibitory avoidance task. Neurobiol Learn Mem. 1999;72(1):8-12.
Ferry, B., & McGaugh, J. L. (1999). Clenbuterol administration into the basolateral amygdala post-training enhances retention in an inhibitory avoidance task. Neurobiology of Learning and Memory, 72(1), 8-12.
Ferry B, McGaugh JL. Clenbuterol Administration Into the Basolateral Amygdala Post-training Enhances Retention in an Inhibitory Avoidance Task. Neurobiol Learn Mem. 1999;72(1):8-12. PubMed PMID: 10371711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clenbuterol administration into the basolateral amygdala post-training enhances retention in an inhibitory avoidance task. AU - Ferry,B, AU - McGaugh,J L, PY - 1999/6/18/pubmed PY - 1999/6/18/medline PY - 1999/6/18/entrez SP - 8 EP - 12 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 72 IS - 1 N2 - The present study examined the effects of post-training infusions of the specific beta2-adrenergic agonist clenbuterol into the basolateral nucleus of the amygdala (BLA), on inhibitory avoidance retention. Male Sprague-Dawley rats were surgically implanted with cannulae aimed at the BLA. Animals were microinfused with different doses of clenbuterol (from 1.0 to 1000.0 ng) immediately after training, and retention was tested 48 h later. Clenbuterol dose dependently affected retention performances. Whereas the 10.0-ng dose of clenbuterol induced a significant increase in the performances, the groups injected with the other doses (1.0, 100.0, and 1000.0 ng) of clenbuterol did not differ from the vehicle-injected animals. These findings, indicating that clenbuterol enhanced retention of the inhibitory avoidance task, are in agreement with previous evidence showing that the adrenergic system of the amygdala is involved in the modulation of memory. Moreover, our data support the hypothesis that the memory-modulating effect of the amygdala adrenergic system is mediated, at least in part, by the activation of the beta-adrenoceptors in the BLA. These findings provide further evidence that the BLA is an important brain region in integrating hormonal influences on memory storage. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/10371711/Clenbuterol_administration_into_the_basolateral_amygdala_post_training_enhances_retention_in_an_inhibitory_avoidance_task_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(98)93904-1 DB - PRIME DP - Unbound Medicine ER -