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Worry affects the immune response to phobic fear.
Brain Behav Immun. 1999 Jun; 13(2):80-92.BB

Abstract

Worry, the cognitive enumeration and anticipation of potential future negative events, is associated with autonomic dysregulation, which may in turn have implications for the immune system. People endorsing high (n = 7) and normal levels of trait worry (n = 8) were briefly exposed to a phobic stimulus and the autonomic and immune responses and recovery were assessed. A time-matched control group (n = 6) was not exposed to any stimulus. Both worry groups showed increased heart rate and skin conductance in response to phobic fear. However, only the normal worry group showed a concomitant increase in natural killer cells in peripheral blood. Patterns of change during the follow-up period suggested that phobic fear had disrupted a normal circadian increase in natural killer cells. Adrenergic and hypothalamus-pituitary-adrenal mechanisms may be responsible for the differences between high and normal worry groups in their natural killer cell response to and recovery from phobic fear.

Authors+Show Affiliations

Department of Psychology, University of Kentucky, Lexington, Kentucky 40506-0044, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10373274

Citation

Segerstrom, S C., et al. "Worry Affects the Immune Response to Phobic Fear." Brain, Behavior, and Immunity, vol. 13, no. 2, 1999, pp. 80-92.
Segerstrom SC, Glover DA, Craske MG, et al. Worry affects the immune response to phobic fear. Brain Behav Immun. 1999;13(2):80-92.
Segerstrom, S. C., Glover, D. A., Craske, M. G., & Fahey, J. L. (1999). Worry affects the immune response to phobic fear. Brain, Behavior, and Immunity, 13(2), 80-92.
Segerstrom SC, et al. Worry Affects the Immune Response to Phobic Fear. Brain Behav Immun. 1999;13(2):80-92. PubMed PMID: 10373274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Worry affects the immune response to phobic fear. AU - Segerstrom,S C, AU - Glover,D A, AU - Craske,M G, AU - Fahey,J L, PY - 1999/6/22/pubmed PY - 1999/6/22/medline PY - 1999/6/22/entrez SP - 80 EP - 92 JF - Brain, behavior, and immunity JO - Brain Behav Immun VL - 13 IS - 2 N2 - Worry, the cognitive enumeration and anticipation of potential future negative events, is associated with autonomic dysregulation, which may in turn have implications for the immune system. People endorsing high (n = 7) and normal levels of trait worry (n = 8) were briefly exposed to a phobic stimulus and the autonomic and immune responses and recovery were assessed. A time-matched control group (n = 6) was not exposed to any stimulus. Both worry groups showed increased heart rate and skin conductance in response to phobic fear. However, only the normal worry group showed a concomitant increase in natural killer cells in peripheral blood. Patterns of change during the follow-up period suggested that phobic fear had disrupted a normal circadian increase in natural killer cells. Adrenergic and hypothalamus-pituitary-adrenal mechanisms may be responsible for the differences between high and normal worry groups in their natural killer cell response to and recovery from phobic fear. SN - 0889-1591 UR - https://www.unboundmedicine.com/medline/citation/10373274/Worry_affects_the_immune_response_to_phobic_fear_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(98)90544-X DB - PRIME DP - Unbound Medicine ER -