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Patients younger than 40 years with gastric carcinoma: Helicobacter pylori genotype and associated gastritis phenotype.
Cancer 1999; 85(12):2506-11C

Abstract

BACKGROUND

In the general population, Helicobacter pylori (H. pylori), particularly the cagA positive strain, has been associated with intestinal-type gastric carcinoma. Gastric carcinomas are rarely observed in patients age < or = 40 years. Host-related factors have been thought to be more important than environmental agents in these early-onset cancers. The aim of this study was to ascertain the possible role of H. pylori infection and that of cagA positive strains in the development of gastric carcinoma in these young patients.

METHODS

In this case-control study, 105 gastric carcinoma patients (male-to-female ratio = 1.1; mean age, 34.4 years; range, 16-40 years) and an equal number of controls (matched for gender and age) were retrospectively selected from the same geographic area. The phenotypes of gastritis and H. pylori were histologically assessed, and the presence of the ureC gene, which is indicative of H. pylori infection, and the cagA genotype were determined by polymerase chain reaction. Gastric carcinoma risk was calculated by both univariate and multivariate statistical methods, taking into account the cancer phenotype, the gastritis phenotype detected in both patients and controls, and the H. pylori genotype.

RESULTS

For 74 diffuse and 31 intestinal gastric carcinomas, multivariate logistic regression analysis produced results consistent with those of univariate statistical tests, showing a significant association between gastric carcinoma and both H. pylori infection (odds ratio [OR] = 2.79; 95% confidence interval [CI] = 1.52-5.11) and cagA positive status (OR = 2.94; 95% CI = 1.56-5.52).

CONCLUSIONS

In young Italian patients with gastric carcinoma, the significant association with cagA positive H. pylori infection suggests that the bacterium has an etiologic role in both diffuse-type and intestinal-type gastric carcinoma.

Authors+Show Affiliations

Department of Oncologic and Surgical Sciences, University of Padova and ULSS, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10375095

Citation

Rugge, M, et al. "Patients Younger Than 40 Years With Gastric Carcinoma: Helicobacter Pylori Genotype and Associated Gastritis Phenotype." Cancer, vol. 85, no. 12, 1999, pp. 2506-11.
Rugge M, Busatto G, Cassaro M, et al. Patients younger than 40 years with gastric carcinoma: Helicobacter pylori genotype and associated gastritis phenotype. Cancer. 1999;85(12):2506-11.
Rugge, M., Busatto, G., Cassaro, M., Shiao, Y. H., Russo, V., Leandro, G., ... Covacci, A. (1999). Patients younger than 40 years with gastric carcinoma: Helicobacter pylori genotype and associated gastritis phenotype. Cancer, 85(12), pp. 2506-11.
Rugge M, et al. Patients Younger Than 40 Years With Gastric Carcinoma: Helicobacter Pylori Genotype and Associated Gastritis Phenotype. Cancer. 1999 Jun 15;85(12):2506-11. PubMed PMID: 10375095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patients younger than 40 years with gastric carcinoma: Helicobacter pylori genotype and associated gastritis phenotype. AU - Rugge,M, AU - Busatto,G, AU - Cassaro,M, AU - Shiao,Y H, AU - Russo,V, AU - Leandro,G, AU - Avellini,C, AU - Fabiano,A, AU - Sidoni,A, AU - Covacci,A, PY - 1999/6/22/pubmed PY - 2000/6/20/medline PY - 1999/6/22/entrez SP - 2506 EP - 11 JF - Cancer JO - Cancer VL - 85 IS - 12 N2 - BACKGROUND: In the general population, Helicobacter pylori (H. pylori), particularly the cagA positive strain, has been associated with intestinal-type gastric carcinoma. Gastric carcinomas are rarely observed in patients age < or = 40 years. Host-related factors have been thought to be more important than environmental agents in these early-onset cancers. The aim of this study was to ascertain the possible role of H. pylori infection and that of cagA positive strains in the development of gastric carcinoma in these young patients. METHODS: In this case-control study, 105 gastric carcinoma patients (male-to-female ratio = 1.1; mean age, 34.4 years; range, 16-40 years) and an equal number of controls (matched for gender and age) were retrospectively selected from the same geographic area. The phenotypes of gastritis and H. pylori were histologically assessed, and the presence of the ureC gene, which is indicative of H. pylori infection, and the cagA genotype were determined by polymerase chain reaction. Gastric carcinoma risk was calculated by both univariate and multivariate statistical methods, taking into account the cancer phenotype, the gastritis phenotype detected in both patients and controls, and the H. pylori genotype. RESULTS: For 74 diffuse and 31 intestinal gastric carcinomas, multivariate logistic regression analysis produced results consistent with those of univariate statistical tests, showing a significant association between gastric carcinoma and both H. pylori infection (odds ratio [OR] = 2.79; 95% confidence interval [CI] = 1.52-5.11) and cagA positive status (OR = 2.94; 95% CI = 1.56-5.52). CONCLUSIONS: In young Italian patients with gastric carcinoma, the significant association with cagA positive H. pylori infection suggests that the bacterium has an etiologic role in both diffuse-type and intestinal-type gastric carcinoma. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/10375095/Patients_younger_than_40_years_with_gastric_carcinoma:_Helicobacter_pylori_genotype_and_associated_gastritis_phenotype_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -