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[Melatonin and its wide-spectrum effects: use of melatonin in the treatment of tumors].
Cesk Fysiol. 1999 Feb; 48(1):27-40.CF

Abstract

One of the major physiological roles of melatonin is its synchronizative influence on circadian rhythmicity and the induction of seasonal responses to changes in day length. In seasonally reproductive animals like the hamster, melatonin has been established as antigonadotrophic on the gonadal axis. Melatonin has been used successfully to treat jet lag and some circadian-based sleep disorders. It has the immunomodulatory role, which can be supported by the existence of specific binding sites in lymphoid cells, thymus and spleen. Not negligible is the antioxidative effect of melatonin and the ability to scavenge some reactive forms of oxygen. Melatonin has potentially important influence on the neoplastic growth and direct and indirect oncostatic effect in some forms of neoplasia. The beneficial influence of melatonin alone or its combination with immunotherapy, radiotherapy or chemotherapy in many clinical studies in patients with tumors was demonstrated.

Authors+Show Affiliations

Solár P
Katedra fyziológie zivocíchov a cloveka Prírodovedeckej fakulty Univerzity Pavla Jozefa Safaríka, Kosice.

MeSH

Adjuvants, ImmunologicAnimalsAntioxidantsFree Radical ScavengersHumansMelatoninNeoplasms

Pub Type(s)

English Abstract
Journal Article
Review

Language

slo

PubMed ID

10377603

Citation

Solár, P. "[Melatonin and Its Wide-spectrum Effects: Use of Melatonin in the Treatment of Tumors]." Ceskoslovenska Fysiologie, vol. 48, no. 1, 1999, pp. 27-40.
Solár P. [Melatonin and its wide-spectrum effects: use of melatonin in the treatment of tumors]. Cesk Fysiol. 1999;48(1):27-40.
Solár, P. (1999). [Melatonin and its wide-spectrum effects: use of melatonin in the treatment of tumors]. Ceskoslovenska Fysiologie, 48(1), 27-40.
Solár P. [Melatonin and Its Wide-spectrum Effects: Use of Melatonin in the Treatment of Tumors]. Cesk Fysiol. 1999;48(1):27-40. PubMed PMID: 10377603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Melatonin and its wide-spectrum effects: use of melatonin in the treatment of tumors]. A1 - Solár,P, PY - 1999/6/23/pubmed PY - 1999/6/23/medline PY - 1999/6/23/entrez SP - 27 EP - 40 JF - Ceskoslovenska fysiologie JO - Cesk Fysiol VL - 48 IS - 1 N2 - One of the major physiological roles of melatonin is its synchronizative influence on circadian rhythmicity and the induction of seasonal responses to changes in day length. In seasonally reproductive animals like the hamster, melatonin has been established as antigonadotrophic on the gonadal axis. Melatonin has been used successfully to treat jet lag and some circadian-based sleep disorders. It has the immunomodulatory role, which can be supported by the existence of specific binding sites in lymphoid cells, thymus and spleen. Not negligible is the antioxidative effect of melatonin and the ability to scavenge some reactive forms of oxygen. Melatonin has potentially important influence on the neoplastic growth and direct and indirect oncostatic effect in some forms of neoplasia. The beneficial influence of melatonin alone or its combination with immunotherapy, radiotherapy or chemotherapy in many clinical studies in patients with tumors was demonstrated. SN - 1210-6313 UR - https://www.unboundmedicine.com/medline/citation/10377603/[Melatonin_and_its_wide_spectrum_effects:_use_of_melatonin_in_the_treatment_of_tumors]_ L2 - https://medlineplus.gov/cancerchemotherapy.html DB - PRIME DP - Unbound Medicine ER -