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Combined electroconvulsive therapy and clozapine in treatment-resistant schizophrenia.

Abstract

1. To assess the efficacy and safety of combining electroconvulsive therapy (ECT) and clozapine in patients with treatment-resistant schizophrenia, the authors reviewed use of this combination in four treatment-resistant schizophrenic inpatients and one inpatient with schizophrenia who was intolerant of clozapine doses needed to control her psychosis. 2. The combination of clozapine and bilateral ECT was modestly effective in two treatment-resistant patients and markedly effective in three patients. There was significant overall improvement in patients' Clinical Global Impression (CGI) and Global Assessment of Functioning (GAF) scores (p < 0.005 and p < 0.0004, respectively), however in patients where marked symptomatic improvement was noted, effects were not sustained. 3. One of the patients that showed dramatic yet transient improvement followed by relapses received maintenance ECT but relapsed despite this. 4. The authors saw no adverse effects in connection with the combination of ECT and clozapine. 5. Supplementing clozapine with a course of bilateral ECT appears to be safe and is effective in some patients with refractory schizophrenia, however its beneficial effects may be short-lived. The long-term impact of ECT on the course of schizophrenia in patients incompletely responsive to clozapine is not fully elucidated.

Authors+Show Affiliations

Division of Geriatric Psychiatry, University of Michigan, Ann Arbor, USA. kales@umich.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10378236

Citation

Kales, H C., et al. "Combined Electroconvulsive Therapy and Clozapine in Treatment-resistant Schizophrenia." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 23, no. 3, 1999, pp. 547-56.
Kales HC, Dequardo JR, Tandon R. Combined electroconvulsive therapy and clozapine in treatment-resistant schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1999;23(3):547-56.
Kales, H. C., Dequardo, J. R., & Tandon, R. (1999). Combined electroconvulsive therapy and clozapine in treatment-resistant schizophrenia. Progress in Neuro-psychopharmacology & Biological Psychiatry, 23(3), 547-56.
Kales HC, Dequardo JR, Tandon R. Combined Electroconvulsive Therapy and Clozapine in Treatment-resistant Schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1999;23(3):547-56. PubMed PMID: 10378236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined electroconvulsive therapy and clozapine in treatment-resistant schizophrenia. AU - Kales,H C, AU - Dequardo,J R, AU - Tandon,R, PY - 1999/6/23/pubmed PY - 1999/6/23/medline PY - 1999/6/23/entrez SP - 547 EP - 56 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 23 IS - 3 N2 - 1. To assess the efficacy and safety of combining electroconvulsive therapy (ECT) and clozapine in patients with treatment-resistant schizophrenia, the authors reviewed use of this combination in four treatment-resistant schizophrenic inpatients and one inpatient with schizophrenia who was intolerant of clozapine doses needed to control her psychosis. 2. The combination of clozapine and bilateral ECT was modestly effective in two treatment-resistant patients and markedly effective in three patients. There was significant overall improvement in patients' Clinical Global Impression (CGI) and Global Assessment of Functioning (GAF) scores (p < 0.005 and p < 0.0004, respectively), however in patients where marked symptomatic improvement was noted, effects were not sustained. 3. One of the patients that showed dramatic yet transient improvement followed by relapses received maintenance ECT but relapsed despite this. 4. The authors saw no adverse effects in connection with the combination of ECT and clozapine. 5. Supplementing clozapine with a course of bilateral ECT appears to be safe and is effective in some patients with refractory schizophrenia, however its beneficial effects may be short-lived. The long-term impact of ECT on the course of schizophrenia in patients incompletely responsive to clozapine is not fully elucidated. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/10378236/Combined_electroconvulsive_therapy_and_clozapine_in_treatment_resistant_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(99)00015-9 DB - PRIME DP - Unbound Medicine ER -