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Risk factors associated with symptoms of gastroesophageal reflux.
Am J Med 1999; 106(6):642-9AJ

Abstract

BACKGROUND

Although patients with gastroesophageal reflux are often instructed to change their lifestyle, population-based data on the risk factors for reflux in the United States are lacking.

METHODS

We performed a cross-sectional study in an age- and gender-stratified random sample of the population of Olmsted County, Minnesota. Residents aged 25 to 74 years were mailed a valid self-report questionnaire that measured reflux symptoms and potential risk factors. Logistic regression was used to estimate the odds ratios (OR) with 95% confidence intervals (CI) for reflux symptoms (heartburn or acid regurgitation) associated with potential risk factors.

RESULTS

Overall, 1,524 (72%) of 2,118 eligible subjects responded. A body mass index >30 kg/m2 (OR = 2.8; CI, 1.7 to 4.5), reporting an immediate family member with heartburn or disease of the esophagus or stomach (OR = 2.6; CI, 1.8 to 3.7), a past history of smoking (OR = 1.6; CI, 1.1 to 2.3), consuming more than seven drinks per week (OR = 1.9; Cl, 1.1 to 3.3), and a higher psychosomatic symptom checklist score (OR per 5 units = 1.4; CI, 1.3 to 1.6) were independently associated with frequent (at least weekly) reflux symptoms.

CONCLUSION

Obesity is a strong risk factor for gastroesophageal reflux, although the value of weight reduction remains to be proven. That family history was also a risk factor suggests that there may be a genetic component to the disorder.

Authors+Show Affiliations

Division of Gastroenterology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10378622

Citation

Locke, G R., et al. "Risk Factors Associated With Symptoms of Gastroesophageal Reflux." The American Journal of Medicine, vol. 106, no. 6, 1999, pp. 642-9.
Locke GR, Talley NJ, Fett SL, et al. Risk factors associated with symptoms of gastroesophageal reflux. Am J Med. 1999;106(6):642-9.
Locke, G. R., Talley, N. J., Fett, S. L., Zinsmeister, A. R., & Melton, L. J. (1999). Risk factors associated with symptoms of gastroesophageal reflux. The American Journal of Medicine, 106(6), pp. 642-9.
Locke GR, et al. Risk Factors Associated With Symptoms of Gastroesophageal Reflux. Am J Med. 1999;106(6):642-9. PubMed PMID: 10378622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors associated with symptoms of gastroesophageal reflux. AU - Locke,G R,3rd AU - Talley,N J, AU - Fett,S L, AU - Zinsmeister,A R, AU - Melton,L J,3rd PY - 1999/6/23/pubmed PY - 2001/3/28/medline PY - 1999/6/23/entrez SP - 642 EP - 9 JF - The American journal of medicine JO - Am. J. Med. VL - 106 IS - 6 N2 - BACKGROUND: Although patients with gastroesophageal reflux are often instructed to change their lifestyle, population-based data on the risk factors for reflux in the United States are lacking. METHODS: We performed a cross-sectional study in an age- and gender-stratified random sample of the population of Olmsted County, Minnesota. Residents aged 25 to 74 years were mailed a valid self-report questionnaire that measured reflux symptoms and potential risk factors. Logistic regression was used to estimate the odds ratios (OR) with 95% confidence intervals (CI) for reflux symptoms (heartburn or acid regurgitation) associated with potential risk factors. RESULTS: Overall, 1,524 (72%) of 2,118 eligible subjects responded. A body mass index >30 kg/m2 (OR = 2.8; CI, 1.7 to 4.5), reporting an immediate family member with heartburn or disease of the esophagus or stomach (OR = 2.6; CI, 1.8 to 3.7), a past history of smoking (OR = 1.6; CI, 1.1 to 2.3), consuming more than seven drinks per week (OR = 1.9; Cl, 1.1 to 3.3), and a higher psychosomatic symptom checklist score (OR per 5 units = 1.4; CI, 1.3 to 1.6) were independently associated with frequent (at least weekly) reflux symptoms. CONCLUSION: Obesity is a strong risk factor for gastroesophageal reflux, although the value of weight reduction remains to be proven. That family history was also a risk factor suggests that there may be a genetic component to the disorder. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/10378622/Risk_factors_associated_with_symptoms_of_gastroesophageal_reflux_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002934399001217 DB - PRIME DP - Unbound Medicine ER -