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Can perineural invasion on prostate needle biopsy predict prostate specific antigen recurrence after radical prostatectomy?
J Urol. 1999 Jul; 162(1):103-6.JU

Abstract

PURPOSE

We evaluated the role of perineural invasion identified on prostate needle biopsy as a predictor of prostate specific antigen (PSA) recurrence after radical prostatectomy.

MATERIALS AND METHODS

Between 1993 and 1998 radical prostatectomy was performed in 319 consecutive patients. Prostate needle biopsies were reviewed in all cases. We compared perineural invasion with other preoperative parameters, including digital rectal examination, PSA and biopsy Gleason score, for the ability to predict PSA recurrence with recurrence defined as any serum PSA level greater than 0.2 ng./ml.

RESULTS

Perineural invasion was identified on 77 of 319 preoperative prostate biopsies (24%). There was PSA recurrence in 46 patients (14.4%) at a mean followup of 25.4 months (range 0.2 to 62.1). Perineural invasion statistically correlated with PSA recurrence. Kaplan-Meier analysis revealed disease-free survival rates of 24 versus 64% when perineural invasion was and was not present in the prostate biopsy (p = 0.0003, log rank 12.92). Multivariate analysis demonstrated that perineural invasion (p = 0.012) and PSA (p = 0.005) were independent preoperative predictive factors of PSA recurrence. When perineural invasion was compared with postoperative parameters, including disease stage, surgical margins and seminal vesicle invasion, it was not an independent predictor because it closely correlated with tumor stage.

CONCLUSIONS

Perineural invasion on preoperative prostate needle biopsy is a strong independent predictor of PSA recurrence in patients in whom prostate cancer was treated with radical prostatectomy.

Authors+Show Affiliations

Squier Urological Clinic, College of Physicians and Surgeons and Department of Biostatistics, School of Public Health, Columbia University, Columbia-Presbyterian Medical Center, New York, New York 10032, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10379750

Citation

de la Taille, A, et al. "Can Perineural Invasion On Prostate Needle Biopsy Predict Prostate Specific Antigen Recurrence After Radical Prostatectomy?" The Journal of Urology, vol. 162, no. 1, 1999, pp. 103-6.
de la Taille A, Rubin MA, Bagiella E, et al. Can perineural invasion on prostate needle biopsy predict prostate specific antigen recurrence after radical prostatectomy? J Urol. 1999;162(1):103-6.
de la Taille, A., Rubin, M. A., Bagiella, E., Olsson, C. A., Buttyan, R., Burchardt, T., Knight, C., O'Toole, K. M., & Katz, A. E. (1999). Can perineural invasion on prostate needle biopsy predict prostate specific antigen recurrence after radical prostatectomy? The Journal of Urology, 162(1), 103-6.
de la Taille A, et al. Can Perineural Invasion On Prostate Needle Biopsy Predict Prostate Specific Antigen Recurrence After Radical Prostatectomy. J Urol. 1999;162(1):103-6. PubMed PMID: 10379750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can perineural invasion on prostate needle biopsy predict prostate specific antigen recurrence after radical prostatectomy? AU - de la Taille,A, AU - Rubin,M A, AU - Bagiella,E, AU - Olsson,C A, AU - Buttyan,R, AU - Burchardt,T, AU - Knight,C, AU - O'Toole,K M, AU - Katz,A E, PY - 1999/6/24/pubmed PY - 1999/6/24/medline PY - 1999/6/24/entrez SP - 103 EP - 6 JF - The Journal of urology JO - J Urol VL - 162 IS - 1 N2 - PURPOSE: We evaluated the role of perineural invasion identified on prostate needle biopsy as a predictor of prostate specific antigen (PSA) recurrence after radical prostatectomy. MATERIALS AND METHODS: Between 1993 and 1998 radical prostatectomy was performed in 319 consecutive patients. Prostate needle biopsies were reviewed in all cases. We compared perineural invasion with other preoperative parameters, including digital rectal examination, PSA and biopsy Gleason score, for the ability to predict PSA recurrence with recurrence defined as any serum PSA level greater than 0.2 ng./ml. RESULTS: Perineural invasion was identified on 77 of 319 preoperative prostate biopsies (24%). There was PSA recurrence in 46 patients (14.4%) at a mean followup of 25.4 months (range 0.2 to 62.1). Perineural invasion statistically correlated with PSA recurrence. Kaplan-Meier analysis revealed disease-free survival rates of 24 versus 64% when perineural invasion was and was not present in the prostate biopsy (p = 0.0003, log rank 12.92). Multivariate analysis demonstrated that perineural invasion (p = 0.012) and PSA (p = 0.005) were independent preoperative predictive factors of PSA recurrence. When perineural invasion was compared with postoperative parameters, including disease stage, surgical margins and seminal vesicle invasion, it was not an independent predictor because it closely correlated with tumor stage. CONCLUSIONS: Perineural invasion on preoperative prostate needle biopsy is a strong independent predictor of PSA recurrence in patients in whom prostate cancer was treated with radical prostatectomy. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/10379750/Can_perineural_invasion_on_prostate_needle_biopsy_predict_prostate_specific_antigen_recurrence_after_radical_prostatectomy L2 - https://www.jurology.com/doi/10.1097/00005392-199907000-00025?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -