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Comparison of serum fructosamine and blood glycosylated hemoglobin concentrations for assessment of glycemic control in cats with diabetes mellitus.
J Am Vet Med Assoc. 1999 Jun 15; 214(12):1794-8.JA

Abstract

OBJECTIVE

To correlate serum fructosamine concentrations with established measures of glycemic control and to compare serum fructosamine and blood glycosylated hemoglobin (GHb) concentrations as a means for assessing glycemic control in diabetic cats.

DESIGN

Longitudinal cohort study.

ANIMALS

26 healthy cats, 5 cats with stress-induced hyperglycemia, 15 untreated diabetic cats, and 36 treated diabetic cats.

PROCEDURE

Control of glycemia was classified and monitored and serum fructosamine and blood GHb concentrations were measured for 12 poorly controlled diabetic cats before and after improving glycemic control, 8 well-controlled treated diabetic cats before and after glycemic control deteriorated, and 5 cats with diabetes mellitus before and after onset of stress-induced hyperglycemia.

RESULTS

Mean serum fructosamine and blood GHb concentrations were significantly higher in untreated diabetic cats, compared with healthy cats, and in 24 poorly controlled diabetic cats, compared with 12 well-controlled diabetic cats. Mean serum fructosamine and blood GHb concentrations decreased significantly in 12 poorly controlled diabetic cats after improving glycemic control and increased significantly in 8 well-controlled diabetic cats after glycemic control deteriorated. A significant stress-induced increase in mean blood glucose concentration was evident 12 hours after insulin administration, but not in 5 docile diabetic cats that became fractious.

CLINICAL IMPLICATIONS

Serum fructosamine and blood GHb concentrations are clinically useful tools for monitoring control of glycemia in cats with diabetes mellitus.

Authors+Show Affiliations

Elliott DA
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA.
Nelson RW
No affiliation info available
Reusch CE
No affiliation info available
Feldman EC
No affiliation info available
Neal LA
No affiliation info available

MeSH

AnimalsBlood GlucoseCat DiseasesCatsCohort StudiesDiabetes MellitusFructosamineGlipizideGlycated Hemoglobin AHyperglycemiaHypoglycemic AgentsInsulinLongitudinal StudiesReference Values

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10382020

Citation

Elliott, D A., et al. "Comparison of Serum Fructosamine and Blood Glycosylated Hemoglobin Concentrations for Assessment of Glycemic Control in Cats With Diabetes Mellitus." Journal of the American Veterinary Medical Association, vol. 214, no. 12, 1999, pp. 1794-8.
Elliott DA, Nelson RW, Reusch CE, et al. Comparison of serum fructosamine and blood glycosylated hemoglobin concentrations for assessment of glycemic control in cats with diabetes mellitus. J Am Vet Med Assoc. 1999;214(12):1794-8.
Elliott, D. A., Nelson, R. W., Reusch, C. E., Feldman, E. C., & Neal, L. A. (1999). Comparison of serum fructosamine and blood glycosylated hemoglobin concentrations for assessment of glycemic control in cats with diabetes mellitus. Journal of the American Veterinary Medical Association, 214(12), 1794-8.
Elliott DA, et al. Comparison of Serum Fructosamine and Blood Glycosylated Hemoglobin Concentrations for Assessment of Glycemic Control in Cats With Diabetes Mellitus. J Am Vet Med Assoc. 1999 Jun 15;214(12):1794-8. PubMed PMID: 10382020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of serum fructosamine and blood glycosylated hemoglobin concentrations for assessment of glycemic control in cats with diabetes mellitus. AU - Elliott,D A, AU - Nelson,R W, AU - Reusch,C E, AU - Feldman,E C, AU - Neal,L A, PY - 1999/6/26/pubmed PY - 1999/6/26/medline PY - 1999/6/26/entrez SP - 1794 EP - 8 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 214 IS - 12 N2 - OBJECTIVE: To correlate serum fructosamine concentrations with established measures of glycemic control and to compare serum fructosamine and blood glycosylated hemoglobin (GHb) concentrations as a means for assessing glycemic control in diabetic cats. DESIGN: Longitudinal cohort study. ANIMALS: 26 healthy cats, 5 cats with stress-induced hyperglycemia, 15 untreated diabetic cats, and 36 treated diabetic cats. PROCEDURE: Control of glycemia was classified and monitored and serum fructosamine and blood GHb concentrations were measured for 12 poorly controlled diabetic cats before and after improving glycemic control, 8 well-controlled treated diabetic cats before and after glycemic control deteriorated, and 5 cats with diabetes mellitus before and after onset of stress-induced hyperglycemia. RESULTS: Mean serum fructosamine and blood GHb concentrations were significantly higher in untreated diabetic cats, compared with healthy cats, and in 24 poorly controlled diabetic cats, compared with 12 well-controlled diabetic cats. Mean serum fructosamine and blood GHb concentrations decreased significantly in 12 poorly controlled diabetic cats after improving glycemic control and increased significantly in 8 well-controlled diabetic cats after glycemic control deteriorated. A significant stress-induced increase in mean blood glucose concentration was evident 12 hours after insulin administration, but not in 5 docile diabetic cats that became fractious. CLINICAL IMPLICATIONS: Serum fructosamine and blood GHb concentrations are clinically useful tools for monitoring control of glycemia in cats with diabetes mellitus. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/10382020/Comparison_of_serum_fructosamine_and_blood_glycosylated_hemoglobin_concentrations_for_assessment_of_glycemic_control_in_cats_with_diabetes_mellitus_ L2 - https://medlineplus.gov/hyperglycemia.html DB - PRIME DP - Unbound Medicine ER -