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Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.
Cancer Res 1999; 59(12):2776-80CR

Abstract

Inflammatory myofibroblastic tumor (IMT) is a relatively rare soft tissue tumor. The reactive versus neoplastic pathogenesis of this tumor is unresolved. We found clonal chromosome aberrations involving 2p23 upon metaphase analysis of two IMTs. Fluorescence in situ hybridization with a probe flanking the ALK gene at 2p23 demonstrated rearrangement of the probe in both of these cases and in a third case, and immunohistochemistry revealed ALK expression in all three cases. 2p22-24 involvement has been reported previously in four additional cases of IMT. We suggest that chromosomal rearrangements involving 2p23 near or within ALK are recurrent alterations in IMT and that ALK may have a novel role outside its previously recognized realm of lymphoid neoplasms.

Authors+Show Affiliations

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. cgriffin@jhmi.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10383129

Citation

Griffin, C A., et al. "Recurrent Involvement of 2p23 in Inflammatory Myofibroblastic Tumors." Cancer Research, vol. 59, no. 12, 1999, pp. 2776-80.
Griffin CA, Hawkins AL, Dvorak C, et al. Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. Cancer Res. 1999;59(12):2776-80.
Griffin, C. A., Hawkins, A. L., Dvorak, C., Henkle, C., Ellingham, T., & Perlman, E. J. (1999). Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. Cancer Research, 59(12), pp. 2776-80.
Griffin CA, et al. Recurrent Involvement of 2p23 in Inflammatory Myofibroblastic Tumors. Cancer Res. 1999 Jun 15;59(12):2776-80. PubMed PMID: 10383129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. AU - Griffin,C A, AU - Hawkins,A L, AU - Dvorak,C, AU - Henkle,C, AU - Ellingham,T, AU - Perlman,E J, PY - 1999/6/26/pubmed PY - 1999/6/26/medline PY - 1999/6/26/entrez SP - 2776 EP - 80 JF - Cancer research JO - Cancer Res. VL - 59 IS - 12 N2 - Inflammatory myofibroblastic tumor (IMT) is a relatively rare soft tissue tumor. The reactive versus neoplastic pathogenesis of this tumor is unresolved. We found clonal chromosome aberrations involving 2p23 upon metaphase analysis of two IMTs. Fluorescence in situ hybridization with a probe flanking the ALK gene at 2p23 demonstrated rearrangement of the probe in both of these cases and in a third case, and immunohistochemistry revealed ALK expression in all three cases. 2p22-24 involvement has been reported previously in four additional cases of IMT. We suggest that chromosomal rearrangements involving 2p23 near or within ALK are recurrent alterations in IMT and that ALK may have a novel role outside its previously recognized realm of lymphoid neoplasms. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/10383129/Recurrent_involvement_of_2p23_in_inflammatory_myofibroblastic_tumors_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=10383129 DB - PRIME DP - Unbound Medicine ER -