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Low-dose UVA and UVB have different time courses for suppression of contact hypersensitivity to a recall antigen in humans.
J Invest Dermatol. 1999 Jun; 112(6):939-44.JI

Abstract

This study investigates the relative effects of low-dose solar-simulated ultraviolet, ultraviolet A, and ultraviolet B radiation on the elicitation of contact hypersensitivity to nickel in nickel-allergic volunteers. A xenon arc lamp with changeable filters was used to irradiate groups of volunteers daily, on separate areas of their lower backs, with both solar-simulated ultraviolet (ultraviolet B, ultraviolet AII + ultraviolet AI) and ultraviolet A (same ultraviolet AII content but twice the ultraviolet AI as the solar-simulated ultraviolet spectrum) for 1 and 2 d; 3, 4, and 5 d; and from 1 to 4 wk. A fourth group was irradiated for 1-5 d with the ultraviolet B component of solar-simulated ultraviolet. Following the final irradiation in each group, nickel-containing patches were applied to both ultraviolet-treated sites and adjacent, unirradiated control sites. Erythema caused by nickel contact hypersensitivity at each site was quantitated 72 h later with a reflectance erythema meter. By comparing the nickel reactions of irradiated and unirradiated skin, ultraviolet immunosuppression was assessed with the different spectra and durations of ultraviolet exposure. We found significant immunosuppression with daily doses of ultraviolet B and ultraviolet A equivalent to approximately 6 min of summer sun exposure, and that ultraviolet A and ultraviolet B exerted their maximal immunosuppressive effects at different times. Solar-simulated ultraviolet-induced immunosuppression was significant after one exposure, near-maximal after two exposures and remained elevated thereafter. Ultraviolet B-induced immunosuppression was lower than that induced by solar-simulated ultraviolet, but followed a similar time-course. In contrast, ultraviolet A-induced immunosuppression was transient, peaking after three exposures. Immune responses returned towards normal with subsequent ultraviolet A exposure, suggesting that an adaptive mechanism may prevent immunosuppression by continued ultraviolet A irradiation.

Authors+Show Affiliations

Department of Medicine (Dermatology), University of Sydney at Royal Prince Alfred Hospital, NSW, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10383742

Citation

Damian, D L., et al. "Low-dose UVA and UVB Have Different Time Courses for Suppression of Contact Hypersensitivity to a Recall Antigen in Humans." The Journal of Investigative Dermatology, vol. 112, no. 6, 1999, pp. 939-44.
Damian DL, Barnetson RS, Halliday GM. Low-dose UVA and UVB have different time courses for suppression of contact hypersensitivity to a recall antigen in humans. J Invest Dermatol. 1999;112(6):939-44.
Damian, D. L., Barnetson, R. S., & Halliday, G. M. (1999). Low-dose UVA and UVB have different time courses for suppression of contact hypersensitivity to a recall antigen in humans. The Journal of Investigative Dermatology, 112(6), 939-44.
Damian DL, Barnetson RS, Halliday GM. Low-dose UVA and UVB Have Different Time Courses for Suppression of Contact Hypersensitivity to a Recall Antigen in Humans. J Invest Dermatol. 1999;112(6):939-44. PubMed PMID: 10383742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-dose UVA and UVB have different time courses for suppression of contact hypersensitivity to a recall antigen in humans. AU - Damian,D L, AU - Barnetson,R S, AU - Halliday,G M, PY - 1999/6/26/pubmed PY - 1999/6/26/medline PY - 1999/6/26/entrez SP - 939 EP - 44 JF - The Journal of investigative dermatology JO - J Invest Dermatol VL - 112 IS - 6 N2 - This study investigates the relative effects of low-dose solar-simulated ultraviolet, ultraviolet A, and ultraviolet B radiation on the elicitation of contact hypersensitivity to nickel in nickel-allergic volunteers. A xenon arc lamp with changeable filters was used to irradiate groups of volunteers daily, on separate areas of their lower backs, with both solar-simulated ultraviolet (ultraviolet B, ultraviolet AII + ultraviolet AI) and ultraviolet A (same ultraviolet AII content but twice the ultraviolet AI as the solar-simulated ultraviolet spectrum) for 1 and 2 d; 3, 4, and 5 d; and from 1 to 4 wk. A fourth group was irradiated for 1-5 d with the ultraviolet B component of solar-simulated ultraviolet. Following the final irradiation in each group, nickel-containing patches were applied to both ultraviolet-treated sites and adjacent, unirradiated control sites. Erythema caused by nickel contact hypersensitivity at each site was quantitated 72 h later with a reflectance erythema meter. By comparing the nickel reactions of irradiated and unirradiated skin, ultraviolet immunosuppression was assessed with the different spectra and durations of ultraviolet exposure. We found significant immunosuppression with daily doses of ultraviolet B and ultraviolet A equivalent to approximately 6 min of summer sun exposure, and that ultraviolet A and ultraviolet B exerted their maximal immunosuppressive effects at different times. Solar-simulated ultraviolet-induced immunosuppression was significant after one exposure, near-maximal after two exposures and remained elevated thereafter. Ultraviolet B-induced immunosuppression was lower than that induced by solar-simulated ultraviolet, but followed a similar time-course. In contrast, ultraviolet A-induced immunosuppression was transient, peaking after three exposures. Immune responses returned towards normal with subsequent ultraviolet A exposure, suggesting that an adaptive mechanism may prevent immunosuppression by continued ultraviolet A irradiation. SN - 0022-202X UR - https://www.unboundmedicine.com/medline/citation/10383742/Low_dose_UVA_and_UVB_have_different_time_courses_for_suppression_of_contact_hypersensitivity_to_a_recall_antigen_in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-202X(15)40511-1 DB - PRIME DP - Unbound Medicine ER -