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Phytoestrogens and breast cancer.

Abstract

Phytoestrogens are paradoxical. Because of their structural similarity to the physiological oestrogens, they have been assumed to increase the risk of breast cancer. However, nations where the largest amounts of phytoestrogens are consumed in the diet have the lowest incidence of and rate of death from breast cancer. Although these epidemiological observations do not prove that phytoestrogens have anti-cancer properties, many preclinical experiments support this concept. Some indicate that early life exposure to phytoestrogens may be critical for breast cancer prevention. Clinical studies to define the effect of phytoestrogens on breast cancer recurrence are underway. The recent discovery of a second class of oestrogen receptors, with a differential distribution among the tissues, may enable an explanation of the phytoestrogen paradox. These receptors have opened a way of utilizing phytoestrogens in the treatment of oestrogen-sensitive chronic diseases such as atherosclerosis and osteoporosis.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, University of Alabama at Birmingham, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

10384813

Citation

Barnes, S. "Phytoestrogens and Breast Cancer." Bailliere's Clinical Endocrinology and Metabolism, vol. 12, no. 4, 1998, pp. 559-79.
Barnes S. Phytoestrogens and breast cancer. Baillieres Clin Endocrinol Metab. 1998;12(4):559-79.
Barnes, S. (1998). Phytoestrogens and breast cancer. Bailliere's Clinical Endocrinology and Metabolism, 12(4), pp. 559-79.
Barnes S. Phytoestrogens and Breast Cancer. Baillieres Clin Endocrinol Metab. 1998;12(4):559-79. PubMed PMID: 10384813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytoestrogens and breast cancer. A1 - Barnes,S, PY - 1999/6/29/pubmed PY - 1999/6/29/medline PY - 1999/6/29/entrez SP - 559 EP - 79 JF - Bailliere's clinical endocrinology and metabolism JO - Baillieres Clin. Endocrinol. Metab. VL - 12 IS - 4 N2 - Phytoestrogens are paradoxical. Because of their structural similarity to the physiological oestrogens, they have been assumed to increase the risk of breast cancer. However, nations where the largest amounts of phytoestrogens are consumed in the diet have the lowest incidence of and rate of death from breast cancer. Although these epidemiological observations do not prove that phytoestrogens have anti-cancer properties, many preclinical experiments support this concept. Some indicate that early life exposure to phytoestrogens may be critical for breast cancer prevention. Clinical studies to define the effect of phytoestrogens on breast cancer recurrence are underway. The recent discovery of a second class of oestrogen receptors, with a differential distribution among the tissues, may enable an explanation of the phytoestrogen paradox. These receptors have opened a way of utilizing phytoestrogens in the treatment of oestrogen-sensitive chronic diseases such as atherosclerosis and osteoporosis. SN - 0950-351X UR - https://www.unboundmedicine.com/medline/citation/10384813/Phytoestrogens_and_breast_cancer_ L2 - https://ClinicalTrials.gov/search/term=10384813 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -