Tags

Type your tag names separated by a space and hit enter

The effect of alpha-tocopherol and beta-carotene supplementation on colorectal adenomas in middle-aged male smokers.

Abstract

Epidemiological and experimental studies have indicated that dietary factors such as vitamin C, vitamin E, and beta-carotene are associated with the risk of colorectal cancer. This study was carried out within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study), whose participants were randomly assigned to four supplementation groups: (a) alpha-tocopherol (AT), 50 mg/day; (b) beta-carotene (BC), 20 mg/day; (c) both AT and BC; and (d) placebo. We included the 15,538 ATBC Study participants who had been randomized within the areas of three major cities in southern Finland. Cases of colorectal adenoma (n = 146) were identified by the pathology laboratories in the study areas, and these participants' medical records were collected and reviewed. Alpha-tocopherol supplementation increased the risk for adenomas (relative risk, 1.66; 95% confidence interval, 1.19-2.32), whereas beta-carotene supplementation had no effect on the risk (relative risk, 0.98; 95% confidence interval, 0.71-1.35). Slightly more prediagnosis rectal bleeding and intestinal pain occurred in those adenoma cases who received alpha-tocopherol supplements than in those who did not. Thus, some bias may have resulted, with alpha-tocopherol supplementation leading to more colonoscopies and, thus, to an increased detection of incident polyps in this group. This is further supported by the trial finding that alpha-tocopherol supplementation did not increase the risk of colorectal cancer.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Nutrition, National Public Health Institute, Helsinki, Finland.

    , , , ,

    Source

    MeSH

    Adenoma
    Aged
    Antioxidants
    Bias
    Colorectal Neoplasms
    Double-Blind Method
    Drug Therapy, Combination
    Finland
    Humans
    Incidence
    Male
    Middle Aged
    Proportional Hazards Models
    Risk Factors
    Smoking
    Vitamin E
    beta Carotene

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10385137

    Citation

    Malila, N, et al. "The Effect of Alpha-tocopherol and Beta-carotene Supplementation On Colorectal Adenomas in Middle-aged Male Smokers." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 8, no. 6, 1999, pp. 489-93.
    Malila N, Virtamo J, Virtanen M, et al. The effect of alpha-tocopherol and beta-carotene supplementation on colorectal adenomas in middle-aged male smokers. Cancer Epidemiol Biomarkers Prev. 1999;8(6):489-93.
    Malila, N., Virtamo, J., Virtanen, M., Albanes, D., Tangrea, J. A., & Huttunen, J. K. (1999). The effect of alpha-tocopherol and beta-carotene supplementation on colorectal adenomas in middle-aged male smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 8(6), pp. 489-93.
    Malila N, et al. The Effect of Alpha-tocopherol and Beta-carotene Supplementation On Colorectal Adenomas in Middle-aged Male Smokers. Cancer Epidemiol Biomarkers Prev. 1999;8(6):489-93. PubMed PMID: 10385137.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effect of alpha-tocopherol and beta-carotene supplementation on colorectal adenomas in middle-aged male smokers. AU - Malila,N, AU - Virtamo,J, AU - Virtanen,M, AU - Albanes,D, AU - Tangrea,J A, AU - Huttunen,J K, PY - 1999/6/29/pubmed PY - 1999/6/29/medline PY - 1999/6/29/entrez SP - 489 EP - 93 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 8 IS - 6 N2 - Epidemiological and experimental studies have indicated that dietary factors such as vitamin C, vitamin E, and beta-carotene are associated with the risk of colorectal cancer. This study was carried out within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study), whose participants were randomly assigned to four supplementation groups: (a) alpha-tocopherol (AT), 50 mg/day; (b) beta-carotene (BC), 20 mg/day; (c) both AT and BC; and (d) placebo. We included the 15,538 ATBC Study participants who had been randomized within the areas of three major cities in southern Finland. Cases of colorectal adenoma (n = 146) were identified by the pathology laboratories in the study areas, and these participants' medical records were collected and reviewed. Alpha-tocopherol supplementation increased the risk for adenomas (relative risk, 1.66; 95% confidence interval, 1.19-2.32), whereas beta-carotene supplementation had no effect on the risk (relative risk, 0.98; 95% confidence interval, 0.71-1.35). Slightly more prediagnosis rectal bleeding and intestinal pain occurred in those adenoma cases who received alpha-tocopherol supplements than in those who did not. Thus, some bias may have resulted, with alpha-tocopherol supplementation leading to more colonoscopies and, thus, to an increased detection of incident polyps in this group. This is further supported by the trial finding that alpha-tocopherol supplementation did not increase the risk of colorectal cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/10385137/The_effect_of_alpha_tocopherol_and_beta_carotene_supplementation_on_colorectal_adenomas_in_middle_aged_male_smokers_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=10385137 DB - PRIME DP - Unbound Medicine ER -