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Acute sporadic non-A, non-B hepatitis in Northeastern Brazil: etiology and natural history.
Hepatology. 1999 Jul; 30(1):289-93.Hep

Abstract

In a 4-year follow-up study, patients with acute sporadic non-A, non-B (NANB) hepatitis were evaluated to determine the etiology and natural history of the disease. Acute hepatitis C virus (HCV) was detected in 13 of 43 (30%) of patients, anti-hepatitis E virus (HEV) IgG in 5 (12%), and 25 (58%) were considered non-A-E. The HCV RNA was detected in all HCV patients but none of the non-A-E cases. The initial clinical and biochemical presentation of the HCV and non-A-E cases was quite similar, although 2 of the non-A-E patients had severe disease. The 5 patients who were found to be anti-HEV IgG-reactive recovered within 6 months of follow-up. Of the 13 HCV cases, alanine transaminase (ALT) levels returned to normal in 7 (53. 8%), while 6 (46.2%) continued to show abnormal ALT after 6 months of follow-up. However, 9 (69.2%) of them remained HCV-RNA-positive, denoting virological/biochemical dissociation. Long-term follow-up showed a reappearance of HCV RNA in 2 of the 4 patients who were in virological remission performing 84% of chronicity rate. Acute non-A-E hepatitis patients were less likely to evolve toward chronicity, as compared with acute HCV cases (16% vs. 84%; P =.0001). Only 4 (16%) of the non-A-E patients were hepatitis G virus (HGV)-RNA-positive. Concerning risk factors for acquiring parenterally transmitted viruses, tattooing was the only one that could be associated with HCV transmission (P =.002). No risk factors could be identified for putative non-A-E virus transmission. Liver biopsies performed for chronic HCV patients showed a variable degree of inflammation, while the non-A-E patients presented less severe histological disease.

Authors+Show Affiliations

Hepatology Unit of Bahia, University Hospital of Bahía, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10385669

Citation

Paraná, R, et al. "Acute Sporadic non-A, non-B Hepatitis in Northeastern Brazil: Etiology and Natural History." Hepatology (Baltimore, Md.), vol. 30, no. 1, 1999, pp. 289-93.
Paraná R, Vitvitski L, Andrade Z, et al. Acute sporadic non-A, non-B hepatitis in Northeastern Brazil: etiology and natural history. Hepatology. 1999;30(1):289-93.
Paraná, R., Vitvitski, L., Andrade, Z., Trepo, C., Cotrim, H., Bertillon, P., Silva, F., Silva, L., de Oliveira, I. R., & Lyra, L. (1999). Acute sporadic non-A, non-B hepatitis in Northeastern Brazil: etiology and natural history. Hepatology (Baltimore, Md.), 30(1), 289-93.
Paraná R, et al. Acute Sporadic non-A, non-B Hepatitis in Northeastern Brazil: Etiology and Natural History. Hepatology. 1999;30(1):289-93. PubMed PMID: 10385669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute sporadic non-A, non-B hepatitis in Northeastern Brazil: etiology and natural history. AU - Paraná,R, AU - Vitvitski,L, AU - Andrade,Z, AU - Trepo,C, AU - Cotrim,H, AU - Bertillon,P, AU - Silva,F, AU - Silva,L, AU - de Oliveira,I R, AU - Lyra,L, PY - 1999/7/1/pubmed PY - 1999/7/1/medline PY - 1999/7/1/entrez SP - 289 EP - 93 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 30 IS - 1 N2 - In a 4-year follow-up study, patients with acute sporadic non-A, non-B (NANB) hepatitis were evaluated to determine the etiology and natural history of the disease. Acute hepatitis C virus (HCV) was detected in 13 of 43 (30%) of patients, anti-hepatitis E virus (HEV) IgG in 5 (12%), and 25 (58%) were considered non-A-E. The HCV RNA was detected in all HCV patients but none of the non-A-E cases. The initial clinical and biochemical presentation of the HCV and non-A-E cases was quite similar, although 2 of the non-A-E patients had severe disease. The 5 patients who were found to be anti-HEV IgG-reactive recovered within 6 months of follow-up. Of the 13 HCV cases, alanine transaminase (ALT) levels returned to normal in 7 (53. 8%), while 6 (46.2%) continued to show abnormal ALT after 6 months of follow-up. However, 9 (69.2%) of them remained HCV-RNA-positive, denoting virological/biochemical dissociation. Long-term follow-up showed a reappearance of HCV RNA in 2 of the 4 patients who were in virological remission performing 84% of chronicity rate. Acute non-A-E hepatitis patients were less likely to evolve toward chronicity, as compared with acute HCV cases (16% vs. 84%; P =.0001). Only 4 (16%) of the non-A-E patients were hepatitis G virus (HGV)-RNA-positive. Concerning risk factors for acquiring parenterally transmitted viruses, tattooing was the only one that could be associated with HCV transmission (P =.002). No risk factors could be identified for putative non-A-E virus transmission. Liver biopsies performed for chronic HCV patients showed a variable degree of inflammation, while the non-A-E patients presented less severe histological disease. SN - 0270-9139 UR - https://www.unboundmedicine.com/medline/citation/10385669/Acute_sporadic_non_A_non_B_hepatitis_in_Northeastern_Brazil:_etiology_and_natural_history_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0270913999003390 DB - PRIME DP - Unbound Medicine ER -