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[Genetics of colorectal cancer. II. Hereditary background of sporadic and familial colorectal cancer].
Ned Tijdschr Geneeskd. 1999 Jun 05; 143(23):1207-11.NT

Abstract

About 15% of patients with colorectal cancer have a positive family history: 5% have hereditary colorectal cancer (hereditary non-polyposis colorectal carcinoma (HNPCC), familial adenomatous polyposis (FAP) or some other hereditary syndrome), while in 10% no clear hereditary pattern can be recognized ('familial colorectal cancer'). In sporadic and in familial intestinal cancer, a demonstrable hereditary predisposition may undoubtedly exist. HNPCC is often characterized by microsatellite instability, i.e. an increased number of short DNA sequences in the DNA indicating a disorder in DNA repair and a mutation in a DNA 'mismatch repair' (MMR) gene. Indicative of hereditary bowel cancer on the basis of such an MMR gene mutation are: (a) presence of bowel cancer in > or = 3 relatives, (b) early age at the time of the diagnosis of 'bowel cancer', (c) multiple primary bowel tumours, (d) uterine cancer in the family and (e) bowel and uterine cancer in a woman. Recent data demand a new subdivision of hereditary bowel cancer, based upon both the clinical picture and the results of DNA-tests. The genetic alterations in colonic adenomas and carcinomas are known to a large extent. In future these insights may be important in clinical practice, such as a more individual determination of the patient's prognosis and accordingly, of the treatment and follow-up.

Authors+Show Affiliations

Academisch Ziekenhuis Vrije Universiteit, afd. Klinische Genetica en Antropogenetica, Amsterdam. fh.menko.humgen@med.vu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

dut

PubMed ID

10389535

Citation

Menko, F H., et al. "[Genetics of Colorectal Cancer. II. Hereditary Background of Sporadic and Familial Colorectal Cancer]." Nederlands Tijdschrift Voor Geneeskunde, vol. 143, no. 23, 1999, pp. 1207-11.
Menko FH, Griffioen G, Wijnen JT, et al. [Genetics of colorectal cancer. II. Hereditary background of sporadic and familial colorectal cancer]. Ned Tijdschr Geneeskd. 1999;143(23):1207-11.
Menko, F. H., Griffioen, G., Wijnen, J. T., Tops, C. M., Fodde, R., & Vasen, H. F. (1999). [Genetics of colorectal cancer. II. Hereditary background of sporadic and familial colorectal cancer]. Nederlands Tijdschrift Voor Geneeskunde, 143(23), 1207-11.
Menko FH, et al. [Genetics of Colorectal Cancer. II. Hereditary Background of Sporadic and Familial Colorectal Cancer]. Ned Tijdschr Geneeskd. 1999 Jun 5;143(23):1207-11. PubMed PMID: 10389535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Genetics of colorectal cancer. II. Hereditary background of sporadic and familial colorectal cancer]. AU - Menko,F H, AU - Griffioen,G, AU - Wijnen,J T, AU - Tops,C M, AU - Fodde,R, AU - Vasen,H F, PY - 1999/7/2/pubmed PY - 1999/7/2/medline PY - 1999/7/2/entrez SP - 1207 EP - 11 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 143 IS - 23 N2 - About 15% of patients with colorectal cancer have a positive family history: 5% have hereditary colorectal cancer (hereditary non-polyposis colorectal carcinoma (HNPCC), familial adenomatous polyposis (FAP) or some other hereditary syndrome), while in 10% no clear hereditary pattern can be recognized ('familial colorectal cancer'). In sporadic and in familial intestinal cancer, a demonstrable hereditary predisposition may undoubtedly exist. HNPCC is often characterized by microsatellite instability, i.e. an increased number of short DNA sequences in the DNA indicating a disorder in DNA repair and a mutation in a DNA 'mismatch repair' (MMR) gene. Indicative of hereditary bowel cancer on the basis of such an MMR gene mutation are: (a) presence of bowel cancer in > or = 3 relatives, (b) early age at the time of the diagnosis of 'bowel cancer', (c) multiple primary bowel tumours, (d) uterine cancer in the family and (e) bowel and uterine cancer in a woman. Recent data demand a new subdivision of hereditary bowel cancer, based upon both the clinical picture and the results of DNA-tests. The genetic alterations in colonic adenomas and carcinomas are known to a large extent. In future these insights may be important in clinical practice, such as a more individual determination of the patient's prognosis and accordingly, of the treatment and follow-up. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/10389535/[Genetics_of_colorectal_cancer__II__Hereditary_background_of_sporadic_and_familial_colorectal_cancer]_ L2 - http://www.diseaseinfosearch.org/result/2734 DB - PRIME DP - Unbound Medicine ER -