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The effects of supplementation with alpha-tocopherol and beta-carotene on the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial.
Cancer 1999; 86(1):37-42C

Abstract

BACKGROUND

Dietary components may be both causal and protective in cases of pancreatic carcinoma, but the preventive potential of single constituents has not been evaluated. The authors report the effects of alpha-tocopherol and beta-carotene supplementations on the rates of incidence of and mortality from pancreatic carcinoma in a randomized, controlled trial.

METHODS

The 29,133 participants in the Alpha-Tocopherol Beta-Carotene Cancer Prevention (ATBC) Study were male smokers who were ages 50-69 years at the time they were randomized into 1 of the following 4 intervention groups: dl-alpha-tocopherol (AT; 50 mg/day), beta-carotene (BC; 20 mg/day), both AT and BC, and placebo. The daily supplementation lasted for 5-8 years. Incident cancers were identified through the national Finnish Cancer Registry and death certificates of the Statistics Finland. Results were analyzed by supplementation with Cox regression models.

RESULTS

Effects of both supplementations were statistically nonsignificant. The rate of incidence of pancreatic carcinoma was 25% lower for the men who received beta-carotene supplements (n = 38) compared with the rate for those who did not receive beta-carotene (n = 51) (95% CI, -51% to 14%). Supplementation with alpha-tocopherol (n = 51) increased the rate of incidence by 34% (95% CI, -12% to 105%) compared with the rate for those who did not receive alpha-tocopherol. Mortality from pancreatic carcinoma during the follow-up, adjusted for stage and anatomic location of the tumor, was 19% (95% CI, -47% to 26%) lower among those who received beta-carotene and 11% (95% CI, -28% to 72%) higher among those who received alpha-tocopherol as compared with those who did not receive supplementation.

CONCLUSIONS

Supplementation with beta-carotene or alpha-tocopherol does not have a statistically significant effect on the rate of incidence of pancreatic carcinoma or the rate of mortality caused by this disease.

Authors+Show Affiliations

National Public Health Institute, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10391561

Citation

Rautalahti, M T., et al. "The Effects of Supplementation With Alpha-tocopherol and Beta-carotene On the Incidence and Mortality of Carcinoma of the Pancreas in a Randomized, Controlled Trial." Cancer, vol. 86, no. 1, 1999, pp. 37-42.
Rautalahti MT, Virtamo JR, Taylor PR, et al. The effects of supplementation with alpha-tocopherol and beta-carotene on the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial. Cancer. 1999;86(1):37-42.
Rautalahti, M. T., Virtamo, J. R., Taylor, P. R., Heinonen, O. P., Albanes, D., Haukka, J. K., ... Huttunen, J. (1999). The effects of supplementation with alpha-tocopherol and beta-carotene on the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial. Cancer, 86(1), pp. 37-42.
Rautalahti MT, et al. The Effects of Supplementation With Alpha-tocopherol and Beta-carotene On the Incidence and Mortality of Carcinoma of the Pancreas in a Randomized, Controlled Trial. Cancer. 1999 Jul 1;86(1):37-42. PubMed PMID: 10391561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of supplementation with alpha-tocopherol and beta-carotene on the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial. AU - Rautalahti,M T, AU - Virtamo,J R, AU - Taylor,P R, AU - Heinonen,O P, AU - Albanes,D, AU - Haukka,J K, AU - Edwards,B K, AU - Kärkkäinen,P A, AU - Stolzenberg-Solomon,R Z, AU - Huttunen,J, PY - 1999/7/3/pubmed PY - 2000/6/20/medline PY - 1999/7/3/entrez SP - 37 EP - 42 JF - Cancer JO - Cancer VL - 86 IS - 1 N2 - BACKGROUND: Dietary components may be both causal and protective in cases of pancreatic carcinoma, but the preventive potential of single constituents has not been evaluated. The authors report the effects of alpha-tocopherol and beta-carotene supplementations on the rates of incidence of and mortality from pancreatic carcinoma in a randomized, controlled trial. METHODS: The 29,133 participants in the Alpha-Tocopherol Beta-Carotene Cancer Prevention (ATBC) Study were male smokers who were ages 50-69 years at the time they were randomized into 1 of the following 4 intervention groups: dl-alpha-tocopherol (AT; 50 mg/day), beta-carotene (BC; 20 mg/day), both AT and BC, and placebo. The daily supplementation lasted for 5-8 years. Incident cancers were identified through the national Finnish Cancer Registry and death certificates of the Statistics Finland. Results were analyzed by supplementation with Cox regression models. RESULTS: Effects of both supplementations were statistically nonsignificant. The rate of incidence of pancreatic carcinoma was 25% lower for the men who received beta-carotene supplements (n = 38) compared with the rate for those who did not receive beta-carotene (n = 51) (95% CI, -51% to 14%). Supplementation with alpha-tocopherol (n = 51) increased the rate of incidence by 34% (95% CI, -12% to 105%) compared with the rate for those who did not receive alpha-tocopherol. Mortality from pancreatic carcinoma during the follow-up, adjusted for stage and anatomic location of the tumor, was 19% (95% CI, -47% to 26%) lower among those who received beta-carotene and 11% (95% CI, -28% to 72%) higher among those who received alpha-tocopherol as compared with those who did not receive supplementation. CONCLUSIONS: Supplementation with beta-carotene or alpha-tocopherol does not have a statistically significant effect on the rate of incidence of pancreatic carcinoma or the rate of mortality caused by this disease. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/10391561/The_effects_of_supplementation_with_alpha_tocopherol_and_beta_carotene_on_the_incidence_and_mortality_of_carcinoma_of_the_pancreas_in_a_randomized_controlled_trial_ L2 - https://medlineplus.gov/vitamine.html DB - PRIME DP - Unbound Medicine ER -