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Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females.
J Lipid Res. 1999 Jul; 40(7):1211-21.JL

Abstract

The metabolic and genetic determinants of HDL cholesterol (HDL-C) levels and HDL turnover were studied in 36 normolipidemic female subjects on a whole-food low-fat metabolic diet. Lipid, lipoprotein, and apolipoprotein levels, lipoprotein size, and apolipoprotein turnover parameters were determined, as were genetic variation at one site in the hepatic lipase promoter and six sites in the apolipoprotein AI/CIII/AIV gene cluster. Menopause had no significant effect on HDL-C or turnover. Stepwise multiple regression analysis revealed that HDL-C was most strongly correlated with HDL size, apolipoprotein A-II (apoA-II), and apolipoprotein A-I (apoA-I) levels, which together could account for 90% of the variation in HDL-C. HDL size was inversely correlated with triglycerides, body mass index, and hepatic lipase activity, which together accounted for 82% of the variation in HDL size. The hepatic lipase promoter genotype had a strong effect on hepatic lipase activity and could account for 38% of the variation in hepatic lipase activity. The apoA-I transport rate (AI-TR) was the major determinant of apoA-I levels, but AI-TR was not associated with six common genetic polymorphism in the apoAI/CIII/AIV gene cluster.A simplified model of HDL metabolism is proposed, in which A-I and apoA-II levels combined with triglycerides, and hepatic lipase activity could account for 80% of the variation in HDL-C.

Authors+Show Affiliations

Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10393206

Citation

De Oliveira e Silva, E R., et al. "Metabolic and Genetic Determinants of HDL Metabolism and Hepatic Lipase Activity in Normolipidemic Females." Journal of Lipid Research, vol. 40, no. 7, 1999, pp. 1211-21.
De Oliveira e Silva ER, Kong M, Han Z, et al. Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females. J Lipid Res. 1999;40(7):1211-21.
De Oliveira e Silva, E. R., Kong, M., Han, Z., Starr, C., Kass, E. M., Juo, S. H., Foster, D., Dansky, H. M., Merkel, M., Cundey, K., Brinton, E. A., Breslow, J. L., & Smith, J. D. (1999). Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females. Journal of Lipid Research, 40(7), 1211-21.
De Oliveira e Silva ER, et al. Metabolic and Genetic Determinants of HDL Metabolism and Hepatic Lipase Activity in Normolipidemic Females. J Lipid Res. 1999;40(7):1211-21. PubMed PMID: 10393206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females. AU - De Oliveira e Silva,E R, AU - Kong,M, AU - Han,Z, AU - Starr,C, AU - Kass,E M, AU - Juo,S H, AU - Foster,D, AU - Dansky,H M, AU - Merkel,M, AU - Cundey,K, AU - Brinton,E A, AU - Breslow,J L, AU - Smith,J D, PY - 1999/7/7/pubmed PY - 2001/5/11/medline PY - 1999/7/7/entrez SP - 1211 EP - 21 JF - Journal of lipid research JO - J Lipid Res VL - 40 IS - 7 N2 - The metabolic and genetic determinants of HDL cholesterol (HDL-C) levels and HDL turnover were studied in 36 normolipidemic female subjects on a whole-food low-fat metabolic diet. Lipid, lipoprotein, and apolipoprotein levels, lipoprotein size, and apolipoprotein turnover parameters were determined, as were genetic variation at one site in the hepatic lipase promoter and six sites in the apolipoprotein AI/CIII/AIV gene cluster. Menopause had no significant effect on HDL-C or turnover. Stepwise multiple regression analysis revealed that HDL-C was most strongly correlated with HDL size, apolipoprotein A-II (apoA-II), and apolipoprotein A-I (apoA-I) levels, which together could account for 90% of the variation in HDL-C. HDL size was inversely correlated with triglycerides, body mass index, and hepatic lipase activity, which together accounted for 82% of the variation in HDL size. The hepatic lipase promoter genotype had a strong effect on hepatic lipase activity and could account for 38% of the variation in hepatic lipase activity. The apoA-I transport rate (AI-TR) was the major determinant of apoA-I levels, but AI-TR was not associated with six common genetic polymorphism in the apoAI/CIII/AIV gene cluster.A simplified model of HDL metabolism is proposed, in which A-I and apoA-II levels combined with triglycerides, and hepatic lipase activity could account for 80% of the variation in HDL-C. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/10393206/Metabolic_and_genetic_determinants_of_HDL_metabolism_and_hepatic_lipase_activity_in_normolipidemic_females_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-2275(20)33483-0 DB - PRIME DP - Unbound Medicine ER -