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Synthetic analogues of irlbacholine: a novel antifungal plant metabolite isolated from Irlbachia alata.
J Nat Prod. 1999 Jun; 62(6):824-8.JN

Abstract

Irlbacholine and a series of related analogues were synthesized and their antifungal activities against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus were assessed. The natural bisphosphocholine, irlbacholine, was the most potent compound, its 22-carbon chain length appearing to be optimal.

Authors+Show Affiliations

Lu Q
Shaman Pharmaceuticals, 213 East Grand Avenue, South San Francisco, California 94080-4812, USA.
Ubillas RP
No affiliation info available
Zhou Y
No affiliation info available
Dubenko LG
No affiliation info available
Dener JM
No affiliation info available
Litvak J
No affiliation info available
Phuan PW
No affiliation info available
Flores M
No affiliation info available
Ye Z
No affiliation info available
Gerber RE
No affiliation info available
Truong T
No affiliation info available
Bierer DE
No affiliation info available

MeSH

Antifungal AgentsAspergillus fumigatusCandida albicansCentral AmericaCryptococcus neoformansMicrobial Sensitivity TestsPhosphorylcholinePlants, MedicinalSouth America

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10395496

Citation

Lu, Q, et al. "Synthetic Analogues of Irlbacholine: a Novel Antifungal Plant Metabolite Isolated From Irlbachia Alata." Journal of Natural Products, vol. 62, no. 6, 1999, pp. 824-8.
Lu Q, Ubillas RP, Zhou Y, et al. Synthetic analogues of irlbacholine: a novel antifungal plant metabolite isolated from Irlbachia alata. J Nat Prod. 1999;62(6):824-8.
Lu, Q., Ubillas, R. P., Zhou, Y., Dubenko, L. G., Dener, J. M., Litvak, J., Phuan, P. W., Flores, M., Ye, Z., Gerber, R. E., Truong, T., & Bierer, D. E. (1999). Synthetic analogues of irlbacholine: a novel antifungal plant metabolite isolated from Irlbachia alata. Journal of Natural Products, 62(6), 824-8.
Lu Q, et al. Synthetic Analogues of Irlbacholine: a Novel Antifungal Plant Metabolite Isolated From Irlbachia Alata. J Nat Prod. 1999;62(6):824-8. PubMed PMID: 10395496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthetic analogues of irlbacholine: a novel antifungal plant metabolite isolated from Irlbachia alata. AU - Lu,Q, AU - Ubillas,R P, AU - Zhou,Y, AU - Dubenko,L G, AU - Dener,J M, AU - Litvak,J, AU - Phuan,P W, AU - Flores,M, AU - Ye,Z, AU - Gerber,R E, AU - Truong,T, AU - Bierer,D E, PY - 1999/7/8/pubmed PY - 1999/7/8/medline PY - 1999/7/8/entrez SP - 824 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 62 IS - 6 N2 - Irlbacholine and a series of related analogues were synthesized and their antifungal activities against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus were assessed. The natural bisphosphocholine, irlbacholine, was the most potent compound, its 22-carbon chain length appearing to be optimal. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/10395496/Synthetic_analogues_of_irlbacholine:_a_novel_antifungal_plant_metabolite_isolated_from_Irlbachia_alata_ L2 - https://doi.org/10.1021/np980425n DB - PRIME DP - Unbound Medicine ER -