Tags

Type your tag names separated by a space and hit enter

Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani.
J Infect Dis. 1999 Aug; 180(2):564-7.JI

Abstract

The possibility that the high frequency of treatment failures in Indian kala-azar might be due to infection with antimony-resistant strains of Leishmania donovani has not been experimentally addressed. L. donovani isolates were obtained from splenic aspiration smears of 24 patients in Bihar, India, who either did not respond (15) or did respond (9) to 1 or more full courses of treatment with sodium antimony gluconate (SAG). A strong correlation (P<.001) between clinical response and SAG sensitivity in vitro was observed only when strains were assayed as intracellular amastigotes: responsive isolates ED50=2.4+/-2.6, ED90=6.4+/-7.8 microgram SAG/mL; unresponsive isolates ED50=7.4+/-3.7 microgram SAG/mL, ED90=29.1+/-11.1 SAG/mL. No correlation with clinical response was found by use of extracellular promastigotes (ED50=48+/-22 vs. 52+/-29 microgram/mL). The emergence of antimony-resistant L. donovani strains appears to be a cause of treatment failures in India.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Lira R
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. rlira@nih.gov
Sundar S
No affiliation info available
Makharia A
No affiliation info available
Kenney R
No affiliation info available
Gam A
No affiliation info available
Saraiva E
No affiliation info available
Sacks D
No affiliation info available

MeSH

AdolescentAdultAnimalsAntimony Sodium GluconateAntiprotozoal AgentsChildDrug ResistanceFemaleHumansIndiaLeishmania donovaniLeishmaniasis, VisceralMaleMiddle AgedSpleenTreatment Failure

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10395884

Citation

Lira, R, et al. "Evidence That the High Incidence of Treatment Failures in Indian Kala-azar Is Due to the Emergence of Antimony-resistant Strains of Leishmania Donovani." The Journal of Infectious Diseases, vol. 180, no. 2, 1999, pp. 564-7.
Lira R, Sundar S, Makharia A, et al. Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani. J Infect Dis. 1999;180(2):564-7.
Lira, R., Sundar, S., Makharia, A., Kenney, R., Gam, A., Saraiva, E., & Sacks, D. (1999). Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani. The Journal of Infectious Diseases, 180(2), 564-7.
Lira R, et al. Evidence That the High Incidence of Treatment Failures in Indian Kala-azar Is Due to the Emergence of Antimony-resistant Strains of Leishmania Donovani. J Infect Dis. 1999;180(2):564-7. PubMed PMID: 10395884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani. AU - Lira,R, AU - Sundar,S, AU - Makharia,A, AU - Kenney,R, AU - Gam,A, AU - Saraiva,E, AU - Sacks,D, PY - 1999/7/9/pubmed PY - 2000/3/21/medline PY - 1999/7/9/entrez SP - 564 EP - 7 JF - The Journal of infectious diseases JO - J Infect Dis VL - 180 IS - 2 N2 - The possibility that the high frequency of treatment failures in Indian kala-azar might be due to infection with antimony-resistant strains of Leishmania donovani has not been experimentally addressed. L. donovani isolates were obtained from splenic aspiration smears of 24 patients in Bihar, India, who either did not respond (15) or did respond (9) to 1 or more full courses of treatment with sodium antimony gluconate (SAG). A strong correlation (P<.001) between clinical response and SAG sensitivity in vitro was observed only when strains were assayed as intracellular amastigotes: responsive isolates ED50=2.4+/-2.6, ED90=6.4+/-7.8 microgram SAG/mL; unresponsive isolates ED50=7.4+/-3.7 microgram SAG/mL, ED90=29.1+/-11.1 SAG/mL. No correlation with clinical response was found by use of extracellular promastigotes (ED50=48+/-22 vs. 52+/-29 microgram/mL). The emergence of antimony-resistant L. donovani strains appears to be a cause of treatment failures in India. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10395884/Evidence_that_the_high_incidence_of_treatment_failures_in_Indian_kala_azar_is_due_to_the_emergence_of_antimony_resistant_strains_of_Leishmania_donovani_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/314896 DB - PRIME DP - Unbound Medicine ER -