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Cord blood leptin concentrations in relation to intrauterine growth.

Abstract

OBJECTIVE

Leptin, a hormone that signals the amount of energy stores to the brain, has recently been shown to play a role in the regulation of several hypothalamic pituitary axes, including the growth hormone axis. To investigate a potential association between cord blood leptin concentrations and intrauterine growth we measured leptin concentrations in the cord blood of small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA) healthy newborns.

PATIENTS AND MEASUREMENTS

Cord blood leptin concentrations were evaluated in 25 SGA, 100 AGA, and 45 LGA, neonates.

RESULTS

Leptin was detectable in all newborns in concentrations comparable with those found in adults. Moreover, SGA newborns had lower leptin concentrations (3.70 +/- 1.81 micrograms/l) than AGA (5.65 +/- 4.98 micrograms/l) and LGA newborns (11.99 +/- 7.06 micrograms/ l)(P < 0.01). Cord blood leptin concentrations were significantly associated with ponderal index, cord blood insulin concentrations, placental weight and maternal serum leptin concentrations. Importantly, the association between cord blood leptin concentrations and intrauterine growth status persisted after adjusting for adiposity, placental weight, maternal serum leptin concentrations and cord blood insulin concentrations.

CONCLUSIONS

Cord blood leptin concentrations are independently associated with intrauterine growth. Future studies are needed to elucidate the underlying mechanism and clarify the role of leptin in regulating growth and controlling appetite in newborns.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Paediatrics, University of Patras Medical School, General University Hospital, Greece.

    ,

    Source

    Clinical endocrinology 50:2 1999 Feb pg 177-83

    MeSH

    Adult
    Embryonic and Fetal Development
    Female
    Fetal Blood
    Humans
    Infant, Newborn
    Infant, Small for Gestational Age
    Insulin
    Leptin
    Male
    Organ Size
    Placenta
    Proteins
    Regression Analysis

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    10396359

    Citation

    Varvarigou, A, et al. "Cord Blood Leptin Concentrations in Relation to Intrauterine Growth." Clinical Endocrinology, vol. 50, no. 2, 1999, pp. 177-83.
    Varvarigou A, Mantzoros CS, Beratis NG. Cord blood leptin concentrations in relation to intrauterine growth. Clin Endocrinol (Oxf). 1999;50(2):177-83.
    Varvarigou, A., Mantzoros, C. S., & Beratis, N. G. (1999). Cord blood leptin concentrations in relation to intrauterine growth. Clinical Endocrinology, 50(2), pp. 177-83.
    Varvarigou A, Mantzoros CS, Beratis NG. Cord Blood Leptin Concentrations in Relation to Intrauterine Growth. Clin Endocrinol (Oxf). 1999;50(2):177-83. PubMed PMID: 10396359.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cord blood leptin concentrations in relation to intrauterine growth. AU - Varvarigou,A, AU - Mantzoros,C S, AU - Beratis,N G, PY - 1999/7/9/pubmed PY - 1999/7/9/medline PY - 1999/7/9/entrez SP - 177 EP - 83 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 50 IS - 2 N2 - OBJECTIVE: Leptin, a hormone that signals the amount of energy stores to the brain, has recently been shown to play a role in the regulation of several hypothalamic pituitary axes, including the growth hormone axis. To investigate a potential association between cord blood leptin concentrations and intrauterine growth we measured leptin concentrations in the cord blood of small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA) healthy newborns. PATIENTS AND MEASUREMENTS: Cord blood leptin concentrations were evaluated in 25 SGA, 100 AGA, and 45 LGA, neonates. RESULTS: Leptin was detectable in all newborns in concentrations comparable with those found in adults. Moreover, SGA newborns had lower leptin concentrations (3.70 +/- 1.81 micrograms/l) than AGA (5.65 +/- 4.98 micrograms/l) and LGA newborns (11.99 +/- 7.06 micrograms/ l)(P < 0.01). Cord blood leptin concentrations were significantly associated with ponderal index, cord blood insulin concentrations, placental weight and maternal serum leptin concentrations. Importantly, the association between cord blood leptin concentrations and intrauterine growth status persisted after adjusting for adiposity, placental weight, maternal serum leptin concentrations and cord blood insulin concentrations. CONCLUSIONS: Cord blood leptin concentrations are independently associated with intrauterine growth. Future studies are needed to elucidate the underlying mechanism and clarify the role of leptin in regulating growth and controlling appetite in newborns. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/10396359/Cord_blood_leptin_concentrations_in_relation_to_intrauterine_growth_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0300-0664&amp;date=1999&amp;volume=50&amp;issue=2&amp;spage=177 DB - PRIME DP - Unbound Medicine ER -