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Morphine alters the structure of neurons in the nucleus accumbens and neocortex of rats.
Synapse. 1999 Aug; 33(2):160-2.S

Abstract

Rats were given repeated injections of 10 mg/kg of morphine and were then left undisturbed for 24-25 days before their brains were processed for Golgi-Cox staining. Prior exposure to morphine decreased the complexity of dendritic branching and the number of dendritic spines on medium spiny neurons in the shell of the nucleus accumbens and on pyramidal cells in the prefrontal and parietal cortex. It is suggested that some of the long-term behavioral consequences of repeated exposure to morphine may be due to its ability to reorganize patterns of synaptic connectivity in the forebrain.

Authors+Show Affiliations

Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48109, USA. ter@umich.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10400894

Citation

Robinson, T E., and B Kolb. "Morphine Alters the Structure of Neurons in the Nucleus Accumbens and Neocortex of Rats." Synapse (New York, N.Y.), vol. 33, no. 2, 1999, pp. 160-2.
Robinson TE, Kolb B. Morphine alters the structure of neurons in the nucleus accumbens and neocortex of rats. Synapse. 1999;33(2):160-2.
Robinson, T. E., & Kolb, B. (1999). Morphine alters the structure of neurons in the nucleus accumbens and neocortex of rats. Synapse (New York, N.Y.), 33(2), 160-2.
Robinson TE, Kolb B. Morphine Alters the Structure of Neurons in the Nucleus Accumbens and Neocortex of Rats. Synapse. 1999;33(2):160-2. PubMed PMID: 10400894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphine alters the structure of neurons in the nucleus accumbens and neocortex of rats. AU - Robinson,T E, AU - Kolb,B, PY - 1999/7/10/pubmed PY - 1999/7/10/medline PY - 1999/7/10/entrez SP - 160 EP - 2 JF - Synapse (New York, N.Y.) JO - Synapse VL - 33 IS - 2 N2 - Rats were given repeated injections of 10 mg/kg of morphine and were then left undisturbed for 24-25 days before their brains were processed for Golgi-Cox staining. Prior exposure to morphine decreased the complexity of dendritic branching and the number of dendritic spines on medium spiny neurons in the shell of the nucleus accumbens and on pyramidal cells in the prefrontal and parietal cortex. It is suggested that some of the long-term behavioral consequences of repeated exposure to morphine may be due to its ability to reorganize patterns of synaptic connectivity in the forebrain. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/10400894/Morphine_alters_the_structure_of_neurons_in_the_nucleus_accumbens_and_neocortex_of_rats_ L2 - https://doi.org/10.1002/(SICI)1098-2396(199908)33:2<160::AID-SYN6>3.0.CO;2-S DB - PRIME DP - Unbound Medicine ER -