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Diets high and low in glycemic index versus high monounsaturated fat diets: effects on glucose and lipid metabolism in NIDDM.
Eur J Clin Nutr 1999; 53(6):473-8EJ

Abstract

OBJECTIVE

To examine the relative effects of high and low glycemic index (GI) carbohydrates, and monounsaturated fats on blood glucose and lipid metabolism in NIDDM subjects.

SUBJECTS

Fourteen male and seven female variably controlled NIDDM subjects recruited by advertisement.

SETTING

Free living outpatients.

RESEARCH DESIGN

A repeated measures, within-subject design was used such that each subject consumed three diets: (a) a high-GI diet (53% CHO -21% fat, 63 GI units (glucose= 100)); (b) a low-GI diet (51% CHO -23% fat, 43 GI units); and (c) a high-mono high-GI diet (42% CHO -35% fat, 59 GI units) in random order and cross-over fashion for four weeks. Approximately 45% energy was provided as key foods which differed in published GI values and specifically excluded legumes. Dietary fibre intake was > 30 g/d on each diet. At the end of each dietary intervention, we measured fasting plasma lipids, glucose, insulin, total glycated plasma protein, fructosamine, LDL and HDL particle size as well as 24 h urinary excretion of glucose and C-peptide.

RESULTS

HDL-cholesterol was higher on the low-GI and high-mono high-GI diets compared to the high-GI diet (P < 0.05 for overall diet effect). There were no other significant differences in metabolic control between diets, even when adjusted for BMI, glucose control or gender. Body weight and saturated fat intake remained stable between dietary interventions.

CONCLUSION

High-mono high-GI and high-CHO, low-GI diets are superior to high-CHO, high-GI diets with respect to HDL metabolism but no effect was noted on glucose metabolism in variably controlled NIDDM subjects.

Authors+Show Affiliations

Department of Physiology, University of Adelaide, South Australia, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10403584

Citation

Luscombe, N D., et al. "Diets High and Low in Glycemic Index Versus High Monounsaturated Fat Diets: Effects On Glucose and Lipid Metabolism in NIDDM." European Journal of Clinical Nutrition, vol. 53, no. 6, 1999, pp. 473-8.
Luscombe ND, Noakes M, Clifton PM. Diets high and low in glycemic index versus high monounsaturated fat diets: effects on glucose and lipid metabolism in NIDDM. Eur J Clin Nutr. 1999;53(6):473-8.
Luscombe, N. D., Noakes, M., & Clifton, P. M. (1999). Diets high and low in glycemic index versus high monounsaturated fat diets: effects on glucose and lipid metabolism in NIDDM. European Journal of Clinical Nutrition, 53(6), pp. 473-8.
Luscombe ND, Noakes M, Clifton PM. Diets High and Low in Glycemic Index Versus High Monounsaturated Fat Diets: Effects On Glucose and Lipid Metabolism in NIDDM. Eur J Clin Nutr. 1999;53(6):473-8. PubMed PMID: 10403584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diets high and low in glycemic index versus high monounsaturated fat diets: effects on glucose and lipid metabolism in NIDDM. AU - Luscombe,N D, AU - Noakes,M, AU - Clifton,P M, PY - 1999/7/14/pubmed PY - 1999/7/14/medline PY - 1999/7/14/entrez SP - 473 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 53 IS - 6 N2 - OBJECTIVE: To examine the relative effects of high and low glycemic index (GI) carbohydrates, and monounsaturated fats on blood glucose and lipid metabolism in NIDDM subjects. SUBJECTS: Fourteen male and seven female variably controlled NIDDM subjects recruited by advertisement. SETTING: Free living outpatients. RESEARCH DESIGN: A repeated measures, within-subject design was used such that each subject consumed three diets: (a) a high-GI diet (53% CHO -21% fat, 63 GI units (glucose= 100)); (b) a low-GI diet (51% CHO -23% fat, 43 GI units); and (c) a high-mono high-GI diet (42% CHO -35% fat, 59 GI units) in random order and cross-over fashion for four weeks. Approximately 45% energy was provided as key foods which differed in published GI values and specifically excluded legumes. Dietary fibre intake was > 30 g/d on each diet. At the end of each dietary intervention, we measured fasting plasma lipids, glucose, insulin, total glycated plasma protein, fructosamine, LDL and HDL particle size as well as 24 h urinary excretion of glucose and C-peptide. RESULTS: HDL-cholesterol was higher on the low-GI and high-mono high-GI diets compared to the high-GI diet (P < 0.05 for overall diet effect). There were no other significant differences in metabolic control between diets, even when adjusted for BMI, glucose control or gender. Body weight and saturated fat intake remained stable between dietary interventions. CONCLUSION: High-mono high-GI and high-CHO, low-GI diets are superior to high-CHO, high-GI diets with respect to HDL metabolism but no effect was noted on glucose metabolism in variably controlled NIDDM subjects. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/10403584/Diets_high_and_low_in_glycemic_index_versus_high_monounsaturated_fat_diets:_effects_on_glucose_and_lipid_metabolism_in_NIDDM_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1600779 DB - PRIME DP - Unbound Medicine ER -