Tags

Type your tag names separated by a space and hit enter

Prevalence and distribution of Helicobacter pylori in gastroesophageal reflux disease: a study from the East.
Am J Gastroenterol 1999; 94(7):1790-4AJ

Abstract

OBJECTIVES

The relationship between Helicobacter pylori infection and gastroesophageal reflux (H. pylori) disease (GERD) is controversial. In Asian populations, the prevalence of H. pylori infection is high and GERD is relatively uncommon. The aim of this study was 1) to test the hypothesis that H. pylori protects the esophagus against GERD, and 2) to study the pattern of H. pylori colonization and gastritis in GERD.

METHODS

We conducted a prospective case-control study in which patients with GERD and asymptomatic controls were compared for the prevalence of H. pylori infection. Diagnosis of GERD was based on symptoms of heartburn that improved with acid-suppressive therapy and/or endoscopic evidence of erosive esophagitis. H. pylori status was determined by serology and, when endoscopy was indicated, was confirmed by rapid urease test and histology. Gastric biopsies were examined under hematoxylin and eosin and Giemsa stains. Density of H. pylori colonization and activity of gastritis at different parts of stomach were graded and compared according to Updated Sydney system.

RESULTS

A total of 106 patients with GERD and 120 age- and sex-matched, asymptomatic controls were enrolled. The prevalence of H. pylori infection was significantly lower in GERD patients (31%) compared with controls (61%, p < 0.001, odds ratio 0.229, 95% confidence interval 0.13-0.41). H. pylori-infected GERD patients showed significantly more severe gastritis in the antrum than in other parts of stomach (mean inflammatory scores: antrum; 3.3 +/- 1.63*, body; 1.85 +/- 1.31; fundus; 1.65 +/- 0.58; cardia, 1.65 +/- 1.39; *p < 0.005). H. pylori colonization was found less commonly and at lower density at the cardia compared with other parts of the stomach.

CONCLUSIONS

H. pylori infection protects against the development of GERD, and carditis is unlikely to play an important role.

Authors+Show Affiliations

Department of Medicine, The Chinese University of Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10406236

Citation

Wu, J C., et al. "Prevalence and Distribution of Helicobacter Pylori in Gastroesophageal Reflux Disease: a Study From the East." The American Journal of Gastroenterology, vol. 94, no. 7, 1999, pp. 1790-4.
Wu JC, Sung JJ, Ng EK, et al. Prevalence and distribution of Helicobacter pylori in gastroesophageal reflux disease: a study from the East. Am J Gastroenterol. 1999;94(7):1790-4.
Wu, J. C., Sung, J. J., Ng, E. K., Go, M. Y., Chan, W. B., Chan, F. K., ... Chung, S. C. (1999). Prevalence and distribution of Helicobacter pylori in gastroesophageal reflux disease: a study from the East. The American Journal of Gastroenterology, 94(7), pp. 1790-4.
Wu JC, et al. Prevalence and Distribution of Helicobacter Pylori in Gastroesophageal Reflux Disease: a Study From the East. Am J Gastroenterol. 1999;94(7):1790-4. PubMed PMID: 10406236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and distribution of Helicobacter pylori in gastroesophageal reflux disease: a study from the East. AU - Wu,J C, AU - Sung,J J, AU - Ng,E K, AU - Go,M Y, AU - Chan,W B, AU - Chan,F K, AU - Leung,W K, AU - Choi,C L, AU - Chung,S C, PY - 1999/7/16/pubmed PY - 1999/7/16/medline PY - 1999/7/16/entrez SP - 1790 EP - 4 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 94 IS - 7 N2 - OBJECTIVES: The relationship between Helicobacter pylori infection and gastroesophageal reflux (H. pylori) disease (GERD) is controversial. In Asian populations, the prevalence of H. pylori infection is high and GERD is relatively uncommon. The aim of this study was 1) to test the hypothesis that H. pylori protects the esophagus against GERD, and 2) to study the pattern of H. pylori colonization and gastritis in GERD. METHODS: We conducted a prospective case-control study in which patients with GERD and asymptomatic controls were compared for the prevalence of H. pylori infection. Diagnosis of GERD was based on symptoms of heartburn that improved with acid-suppressive therapy and/or endoscopic evidence of erosive esophagitis. H. pylori status was determined by serology and, when endoscopy was indicated, was confirmed by rapid urease test and histology. Gastric biopsies were examined under hematoxylin and eosin and Giemsa stains. Density of H. pylori colonization and activity of gastritis at different parts of stomach were graded and compared according to Updated Sydney system. RESULTS: A total of 106 patients with GERD and 120 age- and sex-matched, asymptomatic controls were enrolled. The prevalence of H. pylori infection was significantly lower in GERD patients (31%) compared with controls (61%, p < 0.001, odds ratio 0.229, 95% confidence interval 0.13-0.41). H. pylori-infected GERD patients showed significantly more severe gastritis in the antrum than in other parts of stomach (mean inflammatory scores: antrum; 3.3 +/- 1.63*, body; 1.85 +/- 1.31; fundus; 1.65 +/- 0.58; cardia, 1.65 +/- 1.39; *p < 0.005). H. pylori colonization was found less commonly and at lower density at the cardia compared with other parts of the stomach. CONCLUSIONS: H. pylori infection protects against the development of GERD, and carditis is unlikely to play an important role. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10406236/Prevalence_and_distribution_of_Helicobacter_pylori_in_gastroesophageal_reflux_disease:_a_study_from_the_East_ L2 - http://Insights.ovid.com/pubmed?pmid=10406236 DB - PRIME DP - Unbound Medicine ER -