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Preterm delivery and risk of breast cancer.
Br J Cancer. 1999 May; 80(3-4):609-13.BJ

Abstract

To explore the risk of breast cancer in relation to the length of a pregnancy we tested whether a preterm delivery carries a higher risk of breast cancer than does a full-term delivery. Based on information from the Civil Registration System, and the National Birth Registry in Denmark, we established a population-based cohort of 474 156 women born since April 1935, with vital status and detailed parity information, including the gestational age of liveborn children and stillbirths. Information on spontaneous and induced abortions was obtained from the National Hospital Discharge Registry and the National Registry of Induced Abortions. Incident cases of breast cancer in the cohort (n = 1363) were identified through linkage with the Danish Cancer Registry. The period at risk started in 1978 and continued until a breast cancer diagnosis, death, emigration, or 31 December, 1992, whichever occurred first. After adjusting for attained age, parity, age at first birth and calendar period, we observed the following relative risks of breast cancer for different lengths of the pregnancy: < 29 gestational weeks = 2.11 (95% confidence interval 1.00-4.45); 29-31 weeks = 2.08 (1.20-3.60); 32-33 weeks = 1.12 (0.62-2.04); 34-35 weeks = 1.08 (0.71-1.66); 36-37 weeks = 1.04 (0.83-1.32); 38-39 weeks = 1.02 (0.89-1.17); 40 weeks = 1 (reference). Parous women who had a preterm delivery below 32 weeks gestation had a 1.72-fold (1.14-2.59) increased risk of breast cancer compared with other parous women. In conclusion, a preterm delivery of 32+ weeks gestation did not significantly increase a woman's risk of contracting breast cancer. Only for the very small group of women with preterm deliveries of less than 32 weeks gestation did we observe an increased risk.

Authors+Show Affiliations

Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

10408874

Citation

Melbye, M, et al. "Preterm Delivery and Risk of Breast Cancer." British Journal of Cancer, vol. 80, no. 3-4, 1999, pp. 609-13.
Melbye M, Wohlfahrt J, Andersen AM, et al. Preterm delivery and risk of breast cancer. Br J Cancer. 1999;80(3-4):609-13.
Melbye, M., Wohlfahrt, J., Andersen, A. M., Westergaard, T., & Andersen, P. K. (1999). Preterm delivery and risk of breast cancer. British Journal of Cancer, 80(3-4), 609-13.
Melbye M, et al. Preterm Delivery and Risk of Breast Cancer. Br J Cancer. 1999;80(3-4):609-13. PubMed PMID: 10408874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preterm delivery and risk of breast cancer. AU - Melbye,M, AU - Wohlfahrt,J, AU - Andersen,A M, AU - Westergaard,T, AU - Andersen,P K, PY - 1999/7/17/pubmed PY - 1999/7/17/medline PY - 1999/7/17/entrez SP - 609 EP - 13 JF - British journal of cancer JO - Br J Cancer VL - 80 IS - 3-4 N2 - To explore the risk of breast cancer in relation to the length of a pregnancy we tested whether a preterm delivery carries a higher risk of breast cancer than does a full-term delivery. Based on information from the Civil Registration System, and the National Birth Registry in Denmark, we established a population-based cohort of 474 156 women born since April 1935, with vital status and detailed parity information, including the gestational age of liveborn children and stillbirths. Information on spontaneous and induced abortions was obtained from the National Hospital Discharge Registry and the National Registry of Induced Abortions. Incident cases of breast cancer in the cohort (n = 1363) were identified through linkage with the Danish Cancer Registry. The period at risk started in 1978 and continued until a breast cancer diagnosis, death, emigration, or 31 December, 1992, whichever occurred first. After adjusting for attained age, parity, age at first birth and calendar period, we observed the following relative risks of breast cancer for different lengths of the pregnancy: < 29 gestational weeks = 2.11 (95% confidence interval 1.00-4.45); 29-31 weeks = 2.08 (1.20-3.60); 32-33 weeks = 1.12 (0.62-2.04); 34-35 weeks = 1.08 (0.71-1.66); 36-37 weeks = 1.04 (0.83-1.32); 38-39 weeks = 1.02 (0.89-1.17); 40 weeks = 1 (reference). Parous women who had a preterm delivery below 32 weeks gestation had a 1.72-fold (1.14-2.59) increased risk of breast cancer compared with other parous women. In conclusion, a preterm delivery of 32+ weeks gestation did not significantly increase a woman's risk of contracting breast cancer. Only for the very small group of women with preterm deliveries of less than 32 weeks gestation did we observe an increased risk. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/10408874/Preterm_delivery_and_risk_of_breast_cancer_ L2 - https://doi.org/10.1038/sj.bjc.6690399 DB - PRIME DP - Unbound Medicine ER -