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The impact of extranodal spread of lymph node metastases in patients with oral cancer.
Int J Oral Maxillofac Surg 1999; 28(4):279-84IJ

Abstract

A retrospective study of 61 patients with histologically confirmed lymph node metastases was undertaken to evaluate the prognostic significance of extranodal spread (ENS) of metastases on the patterns of treatment failure and survival. ENS was present in 28 (46%) of the 61 patients and it was significantly associated with N stage. T stage, clinical stage, number of positive nodes, level of metastases, mode of treatment, and histological differentiation, however, did not influence the incidence of ENS. The 5-year disease-specific survival rate was 57%. The values for patients with and without ENS were 40% and 72%, respectively, which were statistically significant. The univariate analysis showed that the presence of ENS was a significant predictor of patient survival (P = 0.008). The number and level of positive nodes and postoperative radiotherapy had no prognostic importance. ENS, however, was also associated with an increased risk of distant metastases.

Authors+Show Affiliations

First Department of Oral and Maxillofacial Surgery, School of Dentistry, Niigata University, Niigata City, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10416895

Citation

Shingaki, S, et al. "The Impact of Extranodal Spread of Lymph Node Metastases in Patients With Oral Cancer." International Journal of Oral and Maxillofacial Surgery, vol. 28, no. 4, 1999, pp. 279-84.
Shingaki S, Nomura T, Takada M, et al. The impact of extranodal spread of lymph node metastases in patients with oral cancer. Int J Oral Maxillofac Surg. 1999;28(4):279-84.
Shingaki, S., Nomura, T., Takada, M., Kobayashi, T., Suzuki, I., & Nakajima, T. (1999). The impact of extranodal spread of lymph node metastases in patients with oral cancer. International Journal of Oral and Maxillofacial Surgery, 28(4), pp. 279-84.
Shingaki S, et al. The Impact of Extranodal Spread of Lymph Node Metastases in Patients With Oral Cancer. Int J Oral Maxillofac Surg. 1999;28(4):279-84. PubMed PMID: 10416895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of extranodal spread of lymph node metastases in patients with oral cancer. AU - Shingaki,S, AU - Nomura,T, AU - Takada,M, AU - Kobayashi,T, AU - Suzuki,I, AU - Nakajima,T, PY - 1999/7/23/pubmed PY - 1999/7/23/medline PY - 1999/7/23/entrez SP - 279 EP - 84 JF - International journal of oral and maxillofacial surgery JO - Int J Oral Maxillofac Surg VL - 28 IS - 4 N2 - A retrospective study of 61 patients with histologically confirmed lymph node metastases was undertaken to evaluate the prognostic significance of extranodal spread (ENS) of metastases on the patterns of treatment failure and survival. ENS was present in 28 (46%) of the 61 patients and it was significantly associated with N stage. T stage, clinical stage, number of positive nodes, level of metastases, mode of treatment, and histological differentiation, however, did not influence the incidence of ENS. The 5-year disease-specific survival rate was 57%. The values for patients with and without ENS were 40% and 72%, respectively, which were statistically significant. The univariate analysis showed that the presence of ENS was a significant predictor of patient survival (P = 0.008). The number and level of positive nodes and postoperative radiotherapy had no prognostic importance. ENS, however, was also associated with an increased risk of distant metastases. SN - 0901-5027 UR - https://www.unboundmedicine.com/medline/citation/10416895/The_impact_of_extranodal_spread_of_lymph_node_metastases_in_patients_with_oral_cancer_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10416895.ui DB - PRIME DP - Unbound Medicine ER -