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Following metastatic placental site trophoblastic tumor with urine beta-core fragment.
Gynecol Oncol. 1999 Aug; 74(2):302-3.GO

Abstract

OBJECTIVE

We document a case with metastatic placental site trophoblastic tumor in a 47-year-old postmenopausal women.

METHODS

beta-core fragment was measured in urine using the Triton UGP kit. hCG was also measured using the Bayer Immuno-1hCG assay (at Memorial Sloan-Kettering Cancer Center).

RESULTS

Over 2 years the patient underwent two courses of chemotherapy and two debulking operations. During this time, hCG levels decreased from 227 to 4.1 mIU/ml. hCG levels were close to the limit of detection (<3 mIU/ml), indicating complete or near-complete regression of disease. At this point urine beta-core fragment levels were determined. High levels were detected 7.9 fmol/ml, consistent with the continued existence of tumor (>1.9 fmol/ml). High-dose chemotherapy (CEM) was started with stem cell harvesting. In the following weeks hCG levels failed to identify the tumor (4.1 to <3 mIU/ml). In the first week (during therapy) beta-core fragment levels increased (12 fmol/ml), and in the following weeks (after therapy) levels regressed to 1.2 fmol/ml.

CONCLUSION

Urine beta-core fragment may be a useful tumor maker when serum hCG levels are near to or below the limit of detection.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10419751

Citation

Rinne, K, et al. "Following Metastatic Placental Site Trophoblastic Tumor With Urine Beta-core Fragment." Gynecologic Oncology, vol. 74, no. 2, 1999, pp. 302-3.
Rinne K, Shahabi S, Cole L. Following metastatic placental site trophoblastic tumor with urine beta-core fragment. Gynecol Oncol. 1999;74(2):302-3.
Rinne, K., Shahabi, S., & Cole, L. (1999). Following metastatic placental site trophoblastic tumor with urine beta-core fragment. Gynecologic Oncology, 74(2), 302-3.
Rinne K, Shahabi S, Cole L. Following Metastatic Placental Site Trophoblastic Tumor With Urine Beta-core Fragment. Gynecol Oncol. 1999;74(2):302-3. PubMed PMID: 10419751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Following metastatic placental site trophoblastic tumor with urine beta-core fragment. AU - Rinne,K, AU - Shahabi,S, AU - Cole,L, PY - 1999/7/27/pubmed PY - 1999/7/27/medline PY - 1999/7/27/entrez SP - 302 EP - 3 JF - Gynecologic oncology JO - Gynecol Oncol VL - 74 IS - 2 N2 - OBJECTIVE: We document a case with metastatic placental site trophoblastic tumor in a 47-year-old postmenopausal women. METHODS: beta-core fragment was measured in urine using the Triton UGP kit. hCG was also measured using the Bayer Immuno-1hCG assay (at Memorial Sloan-Kettering Cancer Center). RESULTS: Over 2 years the patient underwent two courses of chemotherapy and two debulking operations. During this time, hCG levels decreased from 227 to 4.1 mIU/ml. hCG levels were close to the limit of detection (<3 mIU/ml), indicating complete or near-complete regression of disease. At this point urine beta-core fragment levels were determined. High levels were detected 7.9 fmol/ml, consistent with the continued existence of tumor (>1.9 fmol/ml). High-dose chemotherapy (CEM) was started with stem cell harvesting. In the following weeks hCG levels failed to identify the tumor (4.1 to <3 mIU/ml). In the first week (during therapy) beta-core fragment levels increased (12 fmol/ml), and in the following weeks (after therapy) levels regressed to 1.2 fmol/ml. CONCLUSION: Urine beta-core fragment may be a useful tumor maker when serum hCG levels are near to or below the limit of detection. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/10419751/Following_metastatic_placental_site_trophoblastic_tumor_with_urine_beta_core_fragment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(99)95438-0 DB - PRIME DP - Unbound Medicine ER -