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Superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase in diabetic rat lenses.
Ophthalmic Res. 1999; 31(5):346-50.OR

Abstract

The activities of the protective enzymes, superoxide dismutase, catalase, glutathione peroxidase and of xanthine oxidase, an enzyme acting as a source of O(-)(2), were measured in the lenses of alloxan-induced diabetic and control rats. Superoxide dismutase and glutathione peroxidase activities were found to be significantly decreased, while catalase and xanthine oxidase activities were increased. This means that the ratio of the oxidant/antioxidant enzymes increases in the diabetic rat lens, suggesting an increased oxidative stress. This imbalance is possibly an important contributing factor in the pathogenesis of diabetic cataract.

Authors+Show Affiliations

Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10420119

Citation

Cekiç, O, et al. "Superoxide Dismutase, Catalase, Glutathione Peroxidase and Xanthine Oxidase in Diabetic Rat Lenses." Ophthalmic Research, vol. 31, no. 5, 1999, pp. 346-50.
Cekiç O, Bardak Y, Totan Y, et al. Superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase in diabetic rat lenses. Ophthalmic Res. 1999;31(5):346-50.
Cekiç, O., Bardak, Y., Totan, Y., Akyol, O., & Zilelioglu, G. (1999). Superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase in diabetic rat lenses. Ophthalmic Research, 31(5), 346-50.
Cekiç O, et al. Superoxide Dismutase, Catalase, Glutathione Peroxidase and Xanthine Oxidase in Diabetic Rat Lenses. Ophthalmic Res. 1999;31(5):346-50. PubMed PMID: 10420119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase in diabetic rat lenses. AU - Cekiç,O, AU - Bardak,Y, AU - Totan,Y, AU - Akyol,O, AU - Zilelioglu,G, PY - 1999/7/27/pubmed PY - 1999/7/27/medline PY - 1999/7/27/entrez SP - 346 EP - 50 JF - Ophthalmic research JO - Ophthalmic Res VL - 31 IS - 5 N2 - The activities of the protective enzymes, superoxide dismutase, catalase, glutathione peroxidase and of xanthine oxidase, an enzyme acting as a source of O(-)(2), were measured in the lenses of alloxan-induced diabetic and control rats. Superoxide dismutase and glutathione peroxidase activities were found to be significantly decreased, while catalase and xanthine oxidase activities were increased. This means that the ratio of the oxidant/antioxidant enzymes increases in the diabetic rat lens, suggesting an increased oxidative stress. This imbalance is possibly an important contributing factor in the pathogenesis of diabetic cataract. SN - 0030-3747 UR - https://www.unboundmedicine.com/medline/citation/10420119/Superoxide_dismutase_catalase_glutathione_peroxidase_and_xanthine_oxidase_in_diabetic_rat_lenses_ L2 - https://www.karger.com?DOI=10.1159/000055557 DB - PRIME DP - Unbound Medicine ER -