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The relation of central adiposity to components of the insulin resistance syndrome in a biracial US population sample.
Ethn Dis. 1999 Spring-Summer; 9(2):218-29.ED

Abstract

The higher rates of type 2 diabetes mellitus, hypertension, and many others factors of the insulin resistant syndrome (IRS) often seen in African Americans compared to whites do not seem to be explained by differences in central obesity. Reasons for this may be due, in part, to the validity of the commonly used anthropometric surrogate of central adiposity. Recent findings have shown that waist circumference is a better surrogate of total body and visceral adipose tissue and is better correlated with CVD than the traditionally used anthropometric indexes of the body mass index or waist/hip ratios. In this study, waist circumference was employed to determine the association between central adiposity and components of the insulin resistance syndrome in blacks (N=1963) and whites (N=4894) from the US national population-based samples. Sex-specific correlation coefficients were used to estimate the association between waist circumference and factors of the IRS. Multiple linear regression analyses were used to determine racial differences in waist circumference and the independent association of waist circumference to some known factors of IRS adjusting for age, BMI, alcohol use, and smoking. Waist circumference was positively correlated with plasma glucose, DBP, SBP, LDL cholesterol, fasting insulin, serum triglyceride, total cholesterol and total cholesterol/HDL ratio in black and white men and women (P<0.01). In both biracial groups, waist circumference was significantly associated with increases in glucose, DBP, LDL cholesterol, total cholesterol, triglyceride and fasting insulin levels controlling for age, BMI, and behavioral risk factors, such as alcohol use and smoking (P<0.05). Our data shows that central adiposity assessed with waist girth did not wholly explain the higher prevalence of IRS components often seen among blacks. The results of this study reinforce the need to encourage the use of waist measure as a public health tool in screening for CVD risks.

Authors+Show Affiliations

Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Stritch School of Medicine, Maywood, Illinois 60153, USA. iokosun@wpo.it.luc.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10421084

Citation

Okosun, I S., et al. "The Relation of Central Adiposity to Components of the Insulin Resistance Syndrome in a Biracial US Population Sample." Ethnicity & Disease, vol. 9, no. 2, 1999, pp. 218-29.
Okosun IS, Cooper RS, Prewitt TE, et al. The relation of central adiposity to components of the insulin resistance syndrome in a biracial US population sample. Ethn Dis. 1999;9(2):218-29.
Okosun, I. S., Cooper, R. S., Prewitt, T. E., & Rotimi, C. N. (1999). The relation of central adiposity to components of the insulin resistance syndrome in a biracial US population sample. Ethnicity & Disease, 9(2), 218-29.
Okosun IS, et al. The Relation of Central Adiposity to Components of the Insulin Resistance Syndrome in a Biracial US Population Sample. Ethn Dis. 1999 Spring-Summer;9(2):218-29. PubMed PMID: 10421084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relation of central adiposity to components of the insulin resistance syndrome in a biracial US population sample. AU - Okosun,I S, AU - Cooper,R S, AU - Prewitt,T E, AU - Rotimi,C N, PY - 1999/7/27/pubmed PY - 1999/7/27/medline PY - 1999/7/27/entrez SP - 218 EP - 29 JF - Ethnicity & disease JO - Ethn Dis VL - 9 IS - 2 N2 - The higher rates of type 2 diabetes mellitus, hypertension, and many others factors of the insulin resistant syndrome (IRS) often seen in African Americans compared to whites do not seem to be explained by differences in central obesity. Reasons for this may be due, in part, to the validity of the commonly used anthropometric surrogate of central adiposity. Recent findings have shown that waist circumference is a better surrogate of total body and visceral adipose tissue and is better correlated with CVD than the traditionally used anthropometric indexes of the body mass index or waist/hip ratios. In this study, waist circumference was employed to determine the association between central adiposity and components of the insulin resistance syndrome in blacks (N=1963) and whites (N=4894) from the US national population-based samples. Sex-specific correlation coefficients were used to estimate the association between waist circumference and factors of the IRS. Multiple linear regression analyses were used to determine racial differences in waist circumference and the independent association of waist circumference to some known factors of IRS adjusting for age, BMI, alcohol use, and smoking. Waist circumference was positively correlated with plasma glucose, DBP, SBP, LDL cholesterol, fasting insulin, serum triglyceride, total cholesterol and total cholesterol/HDL ratio in black and white men and women (P<0.01). In both biracial groups, waist circumference was significantly associated with increases in glucose, DBP, LDL cholesterol, total cholesterol, triglyceride and fasting insulin levels controlling for age, BMI, and behavioral risk factors, such as alcohol use and smoking (P<0.05). Our data shows that central adiposity assessed with waist girth did not wholly explain the higher prevalence of IRS components often seen among blacks. The results of this study reinforce the need to encourage the use of waist measure as a public health tool in screening for CVD risks. SN - 1049-510X UR - https://www.unboundmedicine.com/medline/citation/10421084/The_relation_of_central_adiposity_to_components_of_the_insulin_resistance_syndrome_in_a_biracial_US_population_sample_ L2 - https://ClinicalTrials.gov/search/term=10421084 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -