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Prevalence of GBV-C/hepatitis G virus RNA and E2 antibody among subjects infected with human immunodeficiency virus type 1 after parenteral or sexual exposure.
J Med Virol. 1999 Aug; 58(4):373-7.JM

Abstract

GB virus C (GBV-C) or hepatitis G virus (HGV) is transmitted by the parenteral route but the importance of sexual transmission needs to be ascertained. GBV-C/HGV infections were investigated using RNA and E2-antibody detection methods in 80 subjects infected by the human immunodeficiency virus type 1 (HIV-1) divided into 4 groups of 20 individuals each according to their main risk factor for HIV-1 infection: blood product recipients (group 1), intravenous drug users (group 2), homosexuals (group 3), or heterosexual exposure (group 4). The overall prevalence of GBV-C/HGV infection was 66.3%. No significant difference was observed in GBV-C/ HGV prevalence among the four groups: 75, 75, 55, and 60% in groups 1, 2, 3, and 4, respectively. Hepatitis C virus (HCV) antibodies, used as a control for parenteral exposure, were found in 70% and 90% of the subjects in groups 1 and 2 versus only 15% and 20% of the subjects in groups 3 and 4, respectively (P< .001). Similarly, coinfections with GBV-C/HGV and HCV were significantly associated with the parenteral route (P <.001). These data emphasized the usefulness of combining the detection of RNA and the E2 antibody to determine the actual prevalence of GBV-C/HGV infection. The high prevalence of the GBV-C/HGV markers among the HIV-1-infected subjects, especially those with sexual exposure, provides additional evidence that this route of transmission plays a key role in the epidemiology of GBV-C/HGV. The potential influence of GBV-C/HGV infection on the course of HIV-1 disease needs further evaluation.

Authors+Show Affiliations

Groupe Immunité des Muqueuses et Agents Pathogénes, University of Saint-Etienne, Faculty of Medicine, Department of Microbiology, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10421404

Citation

Bourlet, T, et al. "Prevalence of GBV-C/hepatitis G Virus RNA and E2 Antibody Among Subjects Infected With Human Immunodeficiency Virus Type 1 After Parenteral or Sexual Exposure." Journal of Medical Virology, vol. 58, no. 4, 1999, pp. 373-7.
Bourlet T, Guglielminotti C, Evrard M, et al. Prevalence of GBV-C/hepatitis G virus RNA and E2 antibody among subjects infected with human immunodeficiency virus type 1 after parenteral or sexual exposure. J Med Virol. 1999;58(4):373-7.
Bourlet, T., Guglielminotti, C., Evrard, M., Berthelot, P., Grattard, F., Frésard, A., Lucht, F. R., & Pozzetto, B. (1999). Prevalence of GBV-C/hepatitis G virus RNA and E2 antibody among subjects infected with human immunodeficiency virus type 1 after parenteral or sexual exposure. Journal of Medical Virology, 58(4), 373-7.
Bourlet T, et al. Prevalence of GBV-C/hepatitis G Virus RNA and E2 Antibody Among Subjects Infected With Human Immunodeficiency Virus Type 1 After Parenteral or Sexual Exposure. J Med Virol. 1999;58(4):373-7. PubMed PMID: 10421404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of GBV-C/hepatitis G virus RNA and E2 antibody among subjects infected with human immunodeficiency virus type 1 after parenteral or sexual exposure. AU - Bourlet,T, AU - Guglielminotti,C, AU - Evrard,M, AU - Berthelot,P, AU - Grattard,F, AU - Frésard,A, AU - Lucht,F R, AU - Pozzetto,B, PY - 1999/7/27/pubmed PY - 2000/6/20/medline PY - 1999/7/27/entrez SP - 373 EP - 7 JF - Journal of medical virology JO - J Med Virol VL - 58 IS - 4 N2 - GB virus C (GBV-C) or hepatitis G virus (HGV) is transmitted by the parenteral route but the importance of sexual transmission needs to be ascertained. GBV-C/HGV infections were investigated using RNA and E2-antibody detection methods in 80 subjects infected by the human immunodeficiency virus type 1 (HIV-1) divided into 4 groups of 20 individuals each according to their main risk factor for HIV-1 infection: blood product recipients (group 1), intravenous drug users (group 2), homosexuals (group 3), or heterosexual exposure (group 4). The overall prevalence of GBV-C/HGV infection was 66.3%. No significant difference was observed in GBV-C/ HGV prevalence among the four groups: 75, 75, 55, and 60% in groups 1, 2, 3, and 4, respectively. Hepatitis C virus (HCV) antibodies, used as a control for parenteral exposure, were found in 70% and 90% of the subjects in groups 1 and 2 versus only 15% and 20% of the subjects in groups 3 and 4, respectively (P< .001). Similarly, coinfections with GBV-C/HGV and HCV were significantly associated with the parenteral route (P <.001). These data emphasized the usefulness of combining the detection of RNA and the E2 antibody to determine the actual prevalence of GBV-C/HGV infection. The high prevalence of the GBV-C/HGV markers among the HIV-1-infected subjects, especially those with sexual exposure, provides additional evidence that this route of transmission plays a key role in the epidemiology of GBV-C/HGV. The potential influence of GBV-C/HGV infection on the course of HIV-1 disease needs further evaluation. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/10421404/Prevalence_of_GBV_C/hepatitis_G_virus_RNA_and_E2_antibody_among_subjects_infected_with_human_immunodeficiency_virus_type_1_after_parenteral_or_sexual_exposure_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0146-6615&amp;date=1999&amp;volume=58&amp;issue=4&amp;spage=373 DB - PRIME DP - Unbound Medicine ER -