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Oestradiol and sex hormone-binding globulin in premenopausal and post-menopausal meat-eaters, vegetarians and vegans.

Abstract

Endogenous oestradiol is strongly associated with breast cancer risk but its determinants are poorly understood. To test the hypothesis that vegetarians have lower plasma oestradiol and higher sex hormone-binding globulin (SHBG) than meat-eaters we assayed samples from 640 premenopausal women (153 meat-eaters, 382 vegetarians, 105 vegans) and 457 post-menopausal women (223 meat-eaters, 196 vegetarians, 38 vegans). Vegetarians and vegans had lower mean body mass indices (BMI) and lower plasma cholesterol concentrations than meat-eaters, but there were no statistically significant differences between meat-eaters, vegetarians and vegans in pre- or post-menopausal plasma concentrations of oestradiol or SHBG. Before adjusting for BMI there were small differences in the direction expected, with the vegetarians and vegans having higher SHBG and lower oestradiol (more noticeable amongst post-menopausal women) than the meat-eaters. These small differences were essentially eliminated by adjusting for BMI. Thus this study implies that the relatively low BMI of vegetarians and vegans does cause small changes in SHBG and in post-menopausal oestradiol, but that the composition of vegetarian diets may not have any additional effects on these hormones.

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  • Authors+Show Affiliations

    ,

    Imperial Cancer Research Fund Cancer Epidemiology Unit, Radcliffe Infirmary, Oxford, UK.

    ,

    Source

    British journal of cancer 80:9 1999 Jul pg 1470-5

    MeSH

    Adult
    Breast Neoplasms
    Diet, Vegetarian
    Estradiol
    Female
    Humans
    Middle Aged
    Postmenopause
    Premenopause
    Sex Hormone-Binding Globulin

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10424753

    Citation

    Thomas, H V., et al. "Oestradiol and Sex Hormone-binding Globulin in Premenopausal and Post-menopausal Meat-eaters, Vegetarians and Vegans." British Journal of Cancer, vol. 80, no. 9, 1999, pp. 1470-5.
    Thomas HV, Davey GK, Key TJ. Oestradiol and sex hormone-binding globulin in premenopausal and post-menopausal meat-eaters, vegetarians and vegans. Br J Cancer. 1999;80(9):1470-5.
    Thomas, H. V., Davey, G. K., & Key, T. J. (1999). Oestradiol and sex hormone-binding globulin in premenopausal and post-menopausal meat-eaters, vegetarians and vegans. British Journal of Cancer, 80(9), pp. 1470-5.
    Thomas HV, Davey GK, Key TJ. Oestradiol and Sex Hormone-binding Globulin in Premenopausal and Post-menopausal Meat-eaters, Vegetarians and Vegans. Br J Cancer. 1999;80(9):1470-5. PubMed PMID: 10424753.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oestradiol and sex hormone-binding globulin in premenopausal and post-menopausal meat-eaters, vegetarians and vegans. AU - Thomas,H V, AU - Davey,G K, AU - Key,T J, PY - 1999/7/29/pubmed PY - 1999/7/29/medline PY - 1999/7/29/entrez SP - 1470 EP - 5 JF - British journal of cancer JO - Br. J. Cancer VL - 80 IS - 9 N2 - Endogenous oestradiol is strongly associated with breast cancer risk but its determinants are poorly understood. To test the hypothesis that vegetarians have lower plasma oestradiol and higher sex hormone-binding globulin (SHBG) than meat-eaters we assayed samples from 640 premenopausal women (153 meat-eaters, 382 vegetarians, 105 vegans) and 457 post-menopausal women (223 meat-eaters, 196 vegetarians, 38 vegans). Vegetarians and vegans had lower mean body mass indices (BMI) and lower plasma cholesterol concentrations than meat-eaters, but there were no statistically significant differences between meat-eaters, vegetarians and vegans in pre- or post-menopausal plasma concentrations of oestradiol or SHBG. Before adjusting for BMI there were small differences in the direction expected, with the vegetarians and vegans having higher SHBG and lower oestradiol (more noticeable amongst post-menopausal women) than the meat-eaters. These small differences were essentially eliminated by adjusting for BMI. Thus this study implies that the relatively low BMI of vegetarians and vegans does cause small changes in SHBG and in post-menopausal oestradiol, but that the composition of vegetarian diets may not have any additional effects on these hormones. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/10424753/Oestradiol_and_sex_hormone_binding_globulin_in_premenopausal_and_post_menopausal_meat_eaters_vegetarians_and_vegans_ L2 - http://dx.doi.org/10.1038/sj.bjc.6690546 DB - PRIME DP - Unbound Medicine ER -