Tags

Type your tag names separated by a space and hit enter

Miotic effect and irritation potential of pilocarpine prodrug incorporated into a submicron emulsion vehicle.
Int J Pharm. 1999 Jul 05; 184(1):115-20.IJ

Abstract

Pilocarpine prodrug, O,O'-dipivaloyl(1,2-ethylene) bispilocarpic acid diester, was introduced to a submicron emulsion vehicle in a dose equivalent to 0.5% pilocarpine base, and the formulation was studied in albino rabbits using miotic assay. Compared with pilocarpine HCl 0.5% solution delayed and prolonged miosis was observed after application of the prodrug emulsion. AUC(0-6 h) values for the prodrug emulsion and pilocarpine solution were 9252+/-1345 and 6845+/-1967%xmin, respectively. The prodrug was also administered twice daily for 5 days in the form of aqueous solution or submicron emulsion in order to study ocular irritation. Irritation potential of the prodrug was significantly reduced when submicron emulsion was used as a vehicle.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Medical University of Gdansk, ul.Hallera 107, 80-416, Gdansk, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

10425357

Citation

Sznitowska, M, et al. "Miotic Effect and Irritation Potential of Pilocarpine Prodrug Incorporated Into a Submicron Emulsion Vehicle." International Journal of Pharmaceutics, vol. 184, no. 1, 1999, pp. 115-20.
Sznitowska M, Zurowska-Pryczkowska K, Janicki S, et al. Miotic effect and irritation potential of pilocarpine prodrug incorporated into a submicron emulsion vehicle. Int J Pharm. 1999;184(1):115-20.
Sznitowska, M., Zurowska-Pryczkowska, K., Janicki, S., & Järvinen, T. (1999). Miotic effect and irritation potential of pilocarpine prodrug incorporated into a submicron emulsion vehicle. International Journal of Pharmaceutics, 184(1), 115-20.
Sznitowska M, et al. Miotic Effect and Irritation Potential of Pilocarpine Prodrug Incorporated Into a Submicron Emulsion Vehicle. Int J Pharm. 1999 Jul 5;184(1):115-20. PubMed PMID: 10425357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Miotic effect and irritation potential of pilocarpine prodrug incorporated into a submicron emulsion vehicle. AU - Sznitowska,M, AU - Zurowska-Pryczkowska,K, AU - Janicki,S, AU - Järvinen,T, PY - 1999/7/30/pubmed PY - 1999/7/30/medline PY - 1999/7/30/entrez SP - 115 EP - 20 JF - International journal of pharmaceutics JO - Int J Pharm VL - 184 IS - 1 N2 - Pilocarpine prodrug, O,O'-dipivaloyl(1,2-ethylene) bispilocarpic acid diester, was introduced to a submicron emulsion vehicle in a dose equivalent to 0.5% pilocarpine base, and the formulation was studied in albino rabbits using miotic assay. Compared with pilocarpine HCl 0.5% solution delayed and prolonged miosis was observed after application of the prodrug emulsion. AUC(0-6 h) values for the prodrug emulsion and pilocarpine solution were 9252+/-1345 and 6845+/-1967%xmin, respectively. The prodrug was also administered twice daily for 5 days in the form of aqueous solution or submicron emulsion in order to study ocular irritation. Irritation potential of the prodrug was significantly reduced when submicron emulsion was used as a vehicle. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/10425357/Miotic_effect_and_irritation_potential_of_pilocarpine_prodrug_incorporated_into_a_submicron_emulsion_vehicle_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(99)00106-4 DB - PRIME DP - Unbound Medicine ER -