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Plasma oestrogen fractions in postmenopausal women receiving hormone replacement therapy: influence of route of administration and cigarette smoking.
J Endocrinol. 1999 Aug; 162(2):265-70.JE

Abstract

The aim of this study was to determine the impact of the administration route and cigarette smoking on plasma oestrogen levels during oral and parenteral oestrogen replacement therapy (ERT). Fourteen healthy postmenopausal women (six smokers and eight non-smokers) were recruited for a prospective, randomised, crossover study at a private outpatient medical centre in Oslo, Norway. All patients were randomised to receive cyclic therapy with oestradiol and norethisterone orally or by the transdermal route each for a 6-month period. Plasma levels of oestrone (Oe(1)), oestradiol (Oe(2)) and oestrone sulphate (Oe(1)S) were determined using highly sensitive RIA methods before and during hormone replacement therapy given by the oral and transdermal route. Comparing smokers and non-smokers, plasma levels of Oe(1), Oe(2) and Oe(1)S were all found to be 40-70% lower in smokers compared with non-smokers when ERT was given orally (Oe(1)S, P<0.05; Oe(1) and Oe(2), P<0.01 for both). Oe(2) given orally caused a higher Oe(1)S/Oe(2) ratio but also a higher Oe(1)/Oe(2) ratio compared with parenteral therapy in smokers (40.2 versus 7(.)0, P<0.01; and 3.2 versus 0.8, P<0.05 respectively). No significant differences in these parameters in the different test-situations were seen in non-smokers. Except for a lower level of Oe(1)S in smokers (non-significant), no difference in plasma oestrogen levels between smokers and non-smokers was observed during parenteral therapy. In conclusion, cigarette smoking has been shown to have major impact on plasma oestrogen levels during oral but not during parenteral Oe(2) replacement.

Authors+Show Affiliations

Department of Therapeutic Oncology and Radiophysics, Haukeland University Hospital, N-5021 Bergen, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10425465

Citation

Geisler, J, et al. "Plasma Oestrogen Fractions in Postmenopausal Women Receiving Hormone Replacement Therapy: Influence of Route of Administration and Cigarette Smoking." The Journal of Endocrinology, vol. 162, no. 2, 1999, pp. 265-70.
Geisler J, Omsjø IH, Helle SI, et al. Plasma oestrogen fractions in postmenopausal women receiving hormone replacement therapy: influence of route of administration and cigarette smoking. J Endocrinol. 1999;162(2):265-70.
Geisler, J., Omsjø, I. H., Helle, S. I., Ekse, D., Silsand, T., & Lønning, P. E. (1999). Plasma oestrogen fractions in postmenopausal women receiving hormone replacement therapy: influence of route of administration and cigarette smoking. The Journal of Endocrinology, 162(2), 265-70.
Geisler J, et al. Plasma Oestrogen Fractions in Postmenopausal Women Receiving Hormone Replacement Therapy: Influence of Route of Administration and Cigarette Smoking. J Endocrinol. 1999;162(2):265-70. PubMed PMID: 10425465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma oestrogen fractions in postmenopausal women receiving hormone replacement therapy: influence of route of administration and cigarette smoking. AU - Geisler,J, AU - Omsjø,I H, AU - Helle,S I, AU - Ekse,D, AU - Silsand,T, AU - Lønning,P E, PY - 1999/7/30/pubmed PY - 1999/7/30/medline PY - 1999/7/30/entrez SP - 265 EP - 70 JF - The Journal of endocrinology JO - J Endocrinol VL - 162 IS - 2 N2 - The aim of this study was to determine the impact of the administration route and cigarette smoking on plasma oestrogen levels during oral and parenteral oestrogen replacement therapy (ERT). Fourteen healthy postmenopausal women (six smokers and eight non-smokers) were recruited for a prospective, randomised, crossover study at a private outpatient medical centre in Oslo, Norway. All patients were randomised to receive cyclic therapy with oestradiol and norethisterone orally or by the transdermal route each for a 6-month period. Plasma levels of oestrone (Oe(1)), oestradiol (Oe(2)) and oestrone sulphate (Oe(1)S) were determined using highly sensitive RIA methods before and during hormone replacement therapy given by the oral and transdermal route. Comparing smokers and non-smokers, plasma levels of Oe(1), Oe(2) and Oe(1)S were all found to be 40-70% lower in smokers compared with non-smokers when ERT was given orally (Oe(1)S, P<0.05; Oe(1) and Oe(2), P<0.01 for both). Oe(2) given orally caused a higher Oe(1)S/Oe(2) ratio but also a higher Oe(1)/Oe(2) ratio compared with parenteral therapy in smokers (40.2 versus 7(.)0, P<0.01; and 3.2 versus 0.8, P<0.05 respectively). No significant differences in these parameters in the different test-situations were seen in non-smokers. Except for a lower level of Oe(1)S in smokers (non-significant), no difference in plasma oestrogen levels between smokers and non-smokers was observed during parenteral therapy. In conclusion, cigarette smoking has been shown to have major impact on plasma oestrogen levels during oral but not during parenteral Oe(2) replacement. SN - 0022-0795 UR - https://www.unboundmedicine.com/medline/citation/10425465/Plasma_oestrogen_fractions_in_postmenopausal_women_receiving_hormone_replacement_therapy:_influence_of_route_of_administration_and_cigarette_smoking_ L2 - https://joe.bioscientifica.com/doi/10.1677/joe.0.1620265 DB - PRIME DP - Unbound Medicine ER -