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Prevalence and early diagnosis of coeliac disease in autoimmune thyroid disorders.
Ital J Gastroenterol Hepatol 1999; 31(4):283-7IJ

Abstract

BACKGROUND AND AIMS

Coeliac disease is associated with several autoimmune disorders such as insulin-dependent diabetes, Sjogren's syndrome, Addison's disease and thyroid diseases. The aim of our study was to evaluate the prevalence of coeliac disease in patients affected by autoimmune thyroid diseases by means of anti-gliadin and anti-endomysial antibodies.

PATIENTS

We studied 92 patients affected by autoimmune thyroid diseases (47 chronic autoimmune thyroiditis, 22 Hashimoto's thyroiditis and 23 Graves' disease). Ninety patients with non autoimmune thyroid disorders (51 multifollicular goitre, 28 solitary nodule and 11 papillary carcinoma) and 236 blood donors also took part in the study as control groups.

METHODS

Total serum IgA were measured in all subjects to exclude selective IgA deficiency; then we measured anti-gliadin antibodies and anti-endomysial antibodies. In patients with anti-gliadin/anti-endomysial antibody positivity and/or with haematinic and laboratory signs of malabsorption we carried out gastrointestinal endoscopy with duodenal histological examination.

RESULTS

Among the 92 patients with autoimmune thyroid disease, 4 (4.3%) showed anti-gliadin and anti-endomysial positivity and had coeliac disease; among the 90 patients with non autoimmune thyroid diseases, 1 (1.1%) had coeliac disease; finally, among the blood donors, 1 subject (0.4%) was anti-gliadin-anti-endomysium antibody positive and had coeliac disease. Those subjects presenting with only anti-gliadin antibody positivity did not have coeliac disease.

CONCLUSIONS

These results show that the prevalence of coeliac disease in patients with autoimmune thyroid diseases is significantly increased when compared with the general population (p = 0.009) but not with patients affected by non autoimmune thyroid disorders (p = 0.18). We suggest a serological screening for coeliac disease in all patients with autoimmune thyroid disease measuring anti-endomysial antibodies, considering that early detection and treatment of coeliac disease are effective in preventing its complications.

Authors+Show Affiliations

Department of Internal Medicine, Catholic University S.C., Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10425571

Citation

Cuoco, L, et al. "Prevalence and Early Diagnosis of Coeliac Disease in Autoimmune Thyroid Disorders." Italian Journal of Gastroenterology and Hepatology, vol. 31, no. 4, 1999, pp. 283-7.
Cuoco L, Certo M, Jorizzo RA, et al. Prevalence and early diagnosis of coeliac disease in autoimmune thyroid disorders. Ital J Gastroenterol Hepatol. 1999;31(4):283-7.
Cuoco, L., Certo, M., Jorizzo, R. A., De Vitis, I., Tursi, A., Papa, A., ... Gasbarrini, G. (1999). Prevalence and early diagnosis of coeliac disease in autoimmune thyroid disorders. Italian Journal of Gastroenterology and Hepatology, 31(4), pp. 283-7.
Cuoco L, et al. Prevalence and Early Diagnosis of Coeliac Disease in Autoimmune Thyroid Disorders. Ital J Gastroenterol Hepatol. 1999;31(4):283-7. PubMed PMID: 10425571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and early diagnosis of coeliac disease in autoimmune thyroid disorders. AU - Cuoco,L, AU - Certo,M, AU - Jorizzo,R A, AU - De Vitis,I, AU - Tursi,A, AU - Papa,A, AU - De Marinis,L, AU - Fedeli,P, AU - Fedeli,G, AU - Gasbarrini,G, PY - 1999/7/30/pubmed PY - 1999/7/30/medline PY - 1999/7/30/entrez SP - 283 EP - 7 JF - Italian journal of gastroenterology and hepatology JO - Ital J Gastroenterol Hepatol VL - 31 IS - 4 N2 - BACKGROUND AND AIMS: Coeliac disease is associated with several autoimmune disorders such as insulin-dependent diabetes, Sjogren's syndrome, Addison's disease and thyroid diseases. The aim of our study was to evaluate the prevalence of coeliac disease in patients affected by autoimmune thyroid diseases by means of anti-gliadin and anti-endomysial antibodies. PATIENTS: We studied 92 patients affected by autoimmune thyroid diseases (47 chronic autoimmune thyroiditis, 22 Hashimoto's thyroiditis and 23 Graves' disease). Ninety patients with non autoimmune thyroid disorders (51 multifollicular goitre, 28 solitary nodule and 11 papillary carcinoma) and 236 blood donors also took part in the study as control groups. METHODS: Total serum IgA were measured in all subjects to exclude selective IgA deficiency; then we measured anti-gliadin antibodies and anti-endomysial antibodies. In patients with anti-gliadin/anti-endomysial antibody positivity and/or with haematinic and laboratory signs of malabsorption we carried out gastrointestinal endoscopy with duodenal histological examination. RESULTS: Among the 92 patients with autoimmune thyroid disease, 4 (4.3%) showed anti-gliadin and anti-endomysial positivity and had coeliac disease; among the 90 patients with non autoimmune thyroid diseases, 1 (1.1%) had coeliac disease; finally, among the blood donors, 1 subject (0.4%) was anti-gliadin-anti-endomysium antibody positive and had coeliac disease. Those subjects presenting with only anti-gliadin antibody positivity did not have coeliac disease. CONCLUSIONS: These results show that the prevalence of coeliac disease in patients with autoimmune thyroid diseases is significantly increased when compared with the general population (p = 0.009) but not with patients affected by non autoimmune thyroid disorders (p = 0.18). We suggest a serological screening for coeliac disease in all patients with autoimmune thyroid disease measuring anti-endomysial antibodies, considering that early detection and treatment of coeliac disease are effective in preventing its complications. SN - 1125-8055 UR - https://www.unboundmedicine.com/medline/citation/10425571/Prevalence_and_early_diagnosis_of_coeliac_disease_in_autoimmune_thyroid_disorders_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -