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Serum cholesterol ester fatty acids in 7- and 13-month-old children in a prospective randomized trial of a low-saturated fat, low-cholesterol diet: the STRIP baby project. Special Turku coronary Risk factor Intervention Project for children.
Acta Paediatr 1999; 88(5):505-12AP

Abstract

To evaluate changes that occur in serum cholesterol ester fatty acid composition during the transition from typical infant feeding to a more adult type of nutrition, this study compared the effects on serum cholesterol ester fatty acids of breast milk or formula at the age of 7 mo with effects caused by 6-mo dietary intervention in 137 children. The intervention [Special Turku coronary Risk factor Intervention Project for children (STRIP baby project)] aimed at a reduction of saturated fat intake to 10% of energy after the age of 1 y without purposefully influencing total fat intake. Nutrient intakes were calculated from 3-d food records. At the age of 7 mo, i.e. before dietary education began, milk type markedly influenced dietary and serum cholesterol ester fatty acid composition (mean serum cholesterol ester 16:0 in breastfed vs formula-fed infants, 13.7% vs 12.0%, respectively, p < 0.001; serum cholesterol ester 18:2n-6 50.6% vs 57.6%, p < 0.001). At the age of 13 mo the calculated fat intake of the intervention and control children differed markedly but serum cholesterol ester fatty acid compositions in all children resembled closely those measured in 7-mo-old breastfed infants, e.g. at the age of 13 mo the relative proportions of 18:2n-6 were 49.9% and 51.1% in previously formula-fed intervention and control children, respectively, and 50.3% and 50.1% in previously breastfed intervention and control children, respectively. In conclusion, serum cholesterol ester fatty acid composition reflected differences in dietary fat quality (breast milk or formula) at the age of 7 mo, whereas dietary intervention as applied in the STRIP baby project had only a minimal effect.

Authors+Show Affiliations

Department of Pediatrics, University of Turku, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10426172

Citation

Salo, P, et al. "Serum Cholesterol Ester Fatty Acids in 7- and 13-month-old Children in a Prospective Randomized Trial of a Low-saturated Fat, Low-cholesterol Diet: the STRIP Baby Project. Special Turku Coronary Risk Factor Intervention Project for Children." Acta Paediatrica (Oslo, Norway : 1992), vol. 88, no. 5, 1999, pp. 505-12.
Salo P, Viikari J, Hämäläinen M, et al. Serum cholesterol ester fatty acids in 7- and 13-month-old children in a prospective randomized trial of a low-saturated fat, low-cholesterol diet: the STRIP baby project. Special Turku coronary Risk factor Intervention Project for children. Acta Paediatr. 1999;88(5):505-12.
Salo, P., Viikari, J., Hämäläinen, M., Lapinleimu, H., Routi, T., Rönnemaa, T., ... Simell, O. (1999). Serum cholesterol ester fatty acids in 7- and 13-month-old children in a prospective randomized trial of a low-saturated fat, low-cholesterol diet: the STRIP baby project. Special Turku coronary Risk factor Intervention Project for children. Acta Paediatrica (Oslo, Norway : 1992), 88(5), pp. 505-12.
Salo P, et al. Serum Cholesterol Ester Fatty Acids in 7- and 13-month-old Children in a Prospective Randomized Trial of a Low-saturated Fat, Low-cholesterol Diet: the STRIP Baby Project. Special Turku Coronary Risk Factor Intervention Project for Children. Acta Paediatr. 1999;88(5):505-12. PubMed PMID: 10426172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cholesterol ester fatty acids in 7- and 13-month-old children in a prospective randomized trial of a low-saturated fat, low-cholesterol diet: the STRIP baby project. Special Turku coronary Risk factor Intervention Project for children. AU - Salo,P, AU - Viikari,J, AU - Hämäläinen,M, AU - Lapinleimu,H, AU - Routi,T, AU - Rönnemaa,T, AU - Seppänen,R, AU - Jokinen,E, AU - Välimäki,I, AU - Simell,O, PY - 1999/7/30/pubmed PY - 1999/7/30/medline PY - 1999/7/30/entrez SP - 505 EP - 12 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 88 IS - 5 N2 - To evaluate changes that occur in serum cholesterol ester fatty acid composition during the transition from typical infant feeding to a more adult type of nutrition, this study compared the effects on serum cholesterol ester fatty acids of breast milk or formula at the age of 7 mo with effects caused by 6-mo dietary intervention in 137 children. The intervention [Special Turku coronary Risk factor Intervention Project for children (STRIP baby project)] aimed at a reduction of saturated fat intake to 10% of energy after the age of 1 y without purposefully influencing total fat intake. Nutrient intakes were calculated from 3-d food records. At the age of 7 mo, i.e. before dietary education began, milk type markedly influenced dietary and serum cholesterol ester fatty acid composition (mean serum cholesterol ester 16:0 in breastfed vs formula-fed infants, 13.7% vs 12.0%, respectively, p < 0.001; serum cholesterol ester 18:2n-6 50.6% vs 57.6%, p < 0.001). At the age of 13 mo the calculated fat intake of the intervention and control children differed markedly but serum cholesterol ester fatty acid compositions in all children resembled closely those measured in 7-mo-old breastfed infants, e.g. at the age of 13 mo the relative proportions of 18:2n-6 were 49.9% and 51.1% in previously formula-fed intervention and control children, respectively, and 50.3% and 50.1% in previously breastfed intervention and control children, respectively. In conclusion, serum cholesterol ester fatty acid composition reflected differences in dietary fat quality (breast milk or formula) at the age of 7 mo, whereas dietary intervention as applied in the STRIP baby project had only a minimal effect. SN - 0803-5253 UR - https://www.unboundmedicine.com/medline/citation/10426172/Serum_cholesterol_ester_fatty_acids_in_7__and_13_month_old_children_in_a_prospective_randomized_trial_of_a_low_saturated_fat_low_cholesterol_diet:_the_STRIP_baby_project__Special_Turku_coronary_Risk_factor_Intervention_Project_for_children_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0803-5253&amp;date=1999&amp;volume=88&amp;issue=5&amp;spage=505 DB - PRIME DP - Unbound Medicine ER -