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Long-term treatment with bromocriptine of a plurihormonal pituitary adenoma secreting thyrotropin, growth hormone and prolactin.
Endocr J. 1999 Feb; 46(1):159-65.EJ

Abstract

A 48-year-old female presented with acromegaly, amenorrhea and hyperthyroidism associated with high serum free T4 levels and measurable TSH concentrations. The administration of GHRH induced significant increases in GH, PRL and TSH. Conversely, intravenous infusion of dopamine or oral administration of bromocriptine effectively inhibited GH, PRL and TSH secretion. Serum alpha-subunit levels were neither affected by GHRH, dopamine nor bromocriptine. Transsphenoidal surgery was performed and immunostaining of the tissue showed that the adenoma cells were positive for GH, PRL or TSH. The patient was treated with bromocriptine at a daily oral dose of 10 mg after surgery. Serum TSH were initially suppressed but returned within reference intervals with persistent normalized free T4 levels. Serum PRL became undetectable and GH levels were stable around 6 ng/ml except the periods of poor drug compliance, when serum TSH, GH and PRL levels rose considerably. The patient was followed-up for 10 years without any change in the residual adenoma tissues as detected by magnetic resonance imaging. These findings suggest that long-term bromocriptine therapy is effective in treating the hypersecretory state of a plurihormonal adenoma secreting TSH, GH and PRL.

Authors+Show Affiliations

Department of Laboratory Medicine, Kyoto University Graduate School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10426581

Citation

Shimatsu, A, et al. "Long-term Treatment With Bromocriptine of a Plurihormonal Pituitary Adenoma Secreting Thyrotropin, Growth Hormone and Prolactin." Endocrine Journal, vol. 46, no. 1, 1999, pp. 159-65.
Shimatsu A, Murabe H, Nakamura Y, et al. Long-term treatment with bromocriptine of a plurihormonal pituitary adenoma secreting thyrotropin, growth hormone and prolactin. Endocr J. 1999;46(1):159-65.
Shimatsu, A., Murabe, H., Nakamura, Y., Mizuta, H., Ihara, C., & Nakao, K. (1999). Long-term treatment with bromocriptine of a plurihormonal pituitary adenoma secreting thyrotropin, growth hormone and prolactin. Endocrine Journal, 46(1), 159-65.
Shimatsu A, et al. Long-term Treatment With Bromocriptine of a Plurihormonal Pituitary Adenoma Secreting Thyrotropin, Growth Hormone and Prolactin. Endocr J. 1999;46(1):159-65. PubMed PMID: 10426581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term treatment with bromocriptine of a plurihormonal pituitary adenoma secreting thyrotropin, growth hormone and prolactin. AU - Shimatsu,A, AU - Murabe,H, AU - Nakamura,Y, AU - Mizuta,H, AU - Ihara,C, AU - Nakao,K, PY - 1999/7/30/pubmed PY - 1999/7/30/medline PY - 1999/7/30/entrez SP - 159 EP - 65 JF - Endocrine journal JO - Endocr J VL - 46 IS - 1 N2 - A 48-year-old female presented with acromegaly, amenorrhea and hyperthyroidism associated with high serum free T4 levels and measurable TSH concentrations. The administration of GHRH induced significant increases in GH, PRL and TSH. Conversely, intravenous infusion of dopamine or oral administration of bromocriptine effectively inhibited GH, PRL and TSH secretion. Serum alpha-subunit levels were neither affected by GHRH, dopamine nor bromocriptine. Transsphenoidal surgery was performed and immunostaining of the tissue showed that the adenoma cells were positive for GH, PRL or TSH. The patient was treated with bromocriptine at a daily oral dose of 10 mg after surgery. Serum TSH were initially suppressed but returned within reference intervals with persistent normalized free T4 levels. Serum PRL became undetectable and GH levels were stable around 6 ng/ml except the periods of poor drug compliance, when serum TSH, GH and PRL levels rose considerably. The patient was followed-up for 10 years without any change in the residual adenoma tissues as detected by magnetic resonance imaging. These findings suggest that long-term bromocriptine therapy is effective in treating the hypersecretory state of a plurihormonal adenoma secreting TSH, GH and PRL. SN - 0918-8959 UR - https://www.unboundmedicine.com/medline/citation/10426581/Long_term_treatment_with_bromocriptine_of_a_plurihormonal_pituitary_adenoma_secreting_thyrotropin_growth_hormone_and_prolactin_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/endocrj1993/46.159?from=PubMed DB - PRIME DP - Unbound Medicine ER -