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Pathological changes in cobalt-supplemented and non-supplemented twin lambs in relation to blood concentrations of methylmalonic acid and homocysteine.
Vet Q. 1999 Jun; 21(3):93-8.VQ

Abstract

In a controlled field study of three years' duration we evaluated the effect of cobalt supplementation on pathological changes in cobalt/vitamin B12-deficient Texel twin lambs grazing the same cobalt-deficient pasture. Semi-quantitative evaluation of the histopathology of liver and brain was done on 44 sets of twins. Pathological changes were related to blood concentrations of vitamin B12, methylmalonic acid, and homocysteine. Lesions were mainly confined to the liver and brain. Acute hepatic changes were characterized by steatosis, hepatocytic degeneration, and single cell necrosis. Chronic changes consisted of bile duct proliferation, the presence of ceroid containing macrophages, and fibrosis in the portal triads. Many non-supplemented lambs showed polymicrocavitation and Alzheimer type II reaction in the brain. Polioencephalomalacia was observed in three non-supplemented lambs but was regarded as a secondary lesion. Our results indicate that the main lesions found in cobalt/vitamin B12-deficient lambs are acute and chronic hepatitis. These lesions were associated with low concentrations of vitamin B12 and high concentrations of methylmalonic acid and homocysteine in the blood. The liver lesions were also associated with polymicrocavitation of the brain, probably as morphological evidence of hepatoencephalopathy.

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Authors+Show Affiliations

Vellema P
Department of Ruminant Health, Animal Health Service, Drachten, The Netherlands. p.vellema@gdvdieren.nl
van den Ingh TS
No affiliation info available
Wouda W
No affiliation info available

MeSH

AnimalsBrainBrain DiseasesCobaltCopperDietFemaleHepatitis, ChronicHomocysteineLitter SizeLiverMaleMethylmalonic AcidSheepSheep DiseasesTwinsVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10427634

Citation

Vellema, P, et al. "Pathological Changes in Cobalt-supplemented and Non-supplemented Twin Lambs in Relation to Blood Concentrations of Methylmalonic Acid and Homocysteine." The Veterinary Quarterly, vol. 21, no. 3, 1999, pp. 93-8.
Vellema P, van den Ingh TS, Wouda W. Pathological changes in cobalt-supplemented and non-supplemented twin lambs in relation to blood concentrations of methylmalonic acid and homocysteine. Vet Q. 1999;21(3):93-8.
Vellema, P., van den Ingh, T. S., & Wouda, W. (1999). Pathological changes in cobalt-supplemented and non-supplemented twin lambs in relation to blood concentrations of methylmalonic acid and homocysteine. The Veterinary Quarterly, 21(3), 93-8.
Vellema P, van den Ingh TS, Wouda W. Pathological Changes in Cobalt-supplemented and Non-supplemented Twin Lambs in Relation to Blood Concentrations of Methylmalonic Acid and Homocysteine. Vet Q. 1999;21(3):93-8. PubMed PMID: 10427634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathological changes in cobalt-supplemented and non-supplemented twin lambs in relation to blood concentrations of methylmalonic acid and homocysteine. AU - Vellema,P, AU - van den Ingh,T S, AU - Wouda,W, PY - 1999/7/31/pubmed PY - 1999/7/31/medline PY - 1999/7/31/entrez SP - 93 EP - 8 JF - The veterinary quarterly JO - Vet Q VL - 21 IS - 3 N2 - In a controlled field study of three years' duration we evaluated the effect of cobalt supplementation on pathological changes in cobalt/vitamin B12-deficient Texel twin lambs grazing the same cobalt-deficient pasture. Semi-quantitative evaluation of the histopathology of liver and brain was done on 44 sets of twins. Pathological changes were related to blood concentrations of vitamin B12, methylmalonic acid, and homocysteine. Lesions were mainly confined to the liver and brain. Acute hepatic changes were characterized by steatosis, hepatocytic degeneration, and single cell necrosis. Chronic changes consisted of bile duct proliferation, the presence of ceroid containing macrophages, and fibrosis in the portal triads. Many non-supplemented lambs showed polymicrocavitation and Alzheimer type II reaction in the brain. Polioencephalomalacia was observed in three non-supplemented lambs but was regarded as a secondary lesion. Our results indicate that the main lesions found in cobalt/vitamin B12-deficient lambs are acute and chronic hepatitis. These lesions were associated with low concentrations of vitamin B12 and high concentrations of methylmalonic acid and homocysteine in the blood. The liver lesions were also associated with polymicrocavitation of the brain, probably as morphological evidence of hepatoencephalopathy. SN - 0165-2176 UR - https://www.unboundmedicine.com/medline/citation/10427634/Pathological_changes_in_cobalt_supplemented_and_non_supplemented_twin_lambs_in_relation_to_blood_concentrations_of_methylmalonic_acid_and_homocysteine_ L2 - https://www.tandfonline.com/doi/full/10.1080/01652176.1999.9695001 DB - PRIME DP - Unbound Medicine ER -